The role of transient receptor potential vanilloid-1 on neural responses to acids by the chorda tympani, glossopharyngeal and superior laryngeal nerves in mice

Arai, Takashi; Ohkuri, Takatoshi; Yasumatsu, Keiko; Kaga, Takayuki; Ninomiya, Yuzo

doi:10.1016/j.neuroscience.2009.11.051

Cited by 37 publications

(34 citation statements)

References 63 publications

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“…Beside the placebo effect, a second reason for the improvement of symptoms can be discussed. As already mentioned, it could be shown that pH \ 6 can stimulate the TRPV-1 receptor which mediates burning sensations [17,18]. The treatment with Omeprazole is possibly able to increase oral pH values in LPR patients and thereby decreases the activation of the TRPV-1 receptor.…”

Section: Discussionmentioning

confidence: 85%

“…An acid taste can be one symptom of an extraesophageal manifestation of reflux. For hydrochloric acid, i.e., one major part of the gastric acid, Arai et al [17] could show an association with burning sensations in the oropharynx of mice via the TRPV-1 receptor. This receptor is present in some somatosensory neurons and acts as a polymodal nociceptor activated by capsaicin, noxious head ([43°C) and acid (pH \ 6) [18,19].…”

Section: Discussionmentioning

confidence: 99%

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Does laryngopharyngeal reflux cause intraoral burning sensations? A preliminary study

Becker

Schmidt

Berghaus

et al. 2011

Eur Arch Otorhinolaryngol

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Intraoral burning sensations are a common problem in the otolaryngological practice. The aim of this study was to evaluate if laryngopharyngeal reflux can cause intraoral burning sensations by measuring oropharyngeal acid reflux. Patients with recurring intraoral burning sensations underwent oropharyngeal pH monitoring in our outpatient clinic. The pH catheter was placed at the level of the uvula. The catheter contained an externally worn transmitter, which wirelessly sent the data to a monitor. In addition, patients were instructed to indicate meals or the occurrence of burning sensations by pressing provided buttons on the monitor. Corresponding events of burning sensations and a significant decrease in oropharyngeal pH values should be visualized. Twenty two patients suffering from recurring intraoral burning sensations underwent oropharyngeal pH measurement for 21-25 h. We could find oropharyngeal reflux episodes in 11 patients. However, we could not detect any episodes of burning sensations in the mouth corresponding with a decrease in oropharyngeal pH values. Our results suggest that there is no causal connection between LPR episodes and the occurrence of intraoral burning sensations in the examined patients. Although further studies with more patients are necessary in the future, we conclude from our findings that recurring intraoral burning sensations are not an indication for proton pump inhibitor therapy.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Does laryngopharyngeal reflux cause intraoral burning sensations? A preliminary study

Becker

Schmidt

Berghaus

et al. 2011

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

show abstract

“…A variant of TRPV1 (TRPV1t) is reportedly expressed in taste buds (31,33), but other studies have not found explicit expression in taste receptor cells (28,29). The response of the CT to Na ϩ , K ϩ , and NH 4 ϩ salts has been reported to be enhanced by TRPV1 agonists such as resiniferatoxin (RTX) and capsaicin (33,34) and suppressed by antagonists of the channel such as SB366791 (33,34,51), iodo-resiniferotoxin (I-RTX) (1,52), and capsazepine (33), but the effectiveness of antagonism varies across studies (6). In some experiments with rodents, blocking both lingual ENaC and TRPV1, has been shown to eliminate the CT response to NaCl (33,34).…”

mentioning

confidence: 99%

Contribution of the TRPV1 channel to salt taste quality in mice as assessed by conditioned taste aversion generalization and chorda tympani nerve responses

Smith

Treesukosol

Paedae

et al. 2012

American Journal of Physiology-Regulatory, Integrative and Comp

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In rodents, at least two transduction mechanisms are involved in salt taste: 1) the sodium-selective epithelial sodium channel, blocked by topical amiloride administration, and 2) one or more amiloride-insensitive cation-nonselective pathways. Whereas electrophysiological evidence from the chorda tympani nerve (CT) has implicated the transient receptor potential vanilloid-1 (TRPV1) channel as a major component of amiloride-insensitive salt taste transduction, behavioral results have provided only equivocal support. Using a brief-access taste test, we examined generalization profiles of water-deprived C57BL/6J (WT) and TRPV1 knockout (KO) mice conditioned (via LiCl injection) to avoid 100 μM amiloride-prepared 0.25 M NaCl and tested with 0.25 M NaCl, sodium gluconate, KCl, NH(4)Cl, 6.625 mM citric acid, 0.15 mM quinine, and 0.5 M sucrose. Both LiCl-injected WT and TRPV1 KO groups learned to avoid NaCl+amiloride relative to controls, but their generalization profiles did not differ; LiCl-injected mice avoided the nonsodium salts and quinine suggesting that a TRPV1-independent pathway contributes to the taste quality of the amiloride-insensitive portion of the NaCl signal. Repeating the experiment but doubling all stimulus concentrations revealed a difference in generalization profiles between genotypes. While both LiCl-injected groups avoided the nonsodium salts and quinine, only WT mice avoided the sodium salts and citric acid. CT responses to these stimuli and a concentration series of NaCl and KCl with and without amiloride did not differ between genotypes. Thus, in our study, TRPV1 did not appear to contribute to sodium salt perception based on gustatory signals, at least in the CT, but may have contributed to the oral somatosensory features of sodium.

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“…7) Electrophysiological experiments have found that oral application of acetic acid produces a larger neural response than either citric or hydrochloric acid even at the same pH. 8,9) Thus cellular responses to acetic acid are partly determined by a factor other than proton release.…”

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confidence: 99%

The Use of Mammalian Cultured Cells Loaded with a Fluorescent Dye Shows Specific Membrane Penetration of Undissociated Acetic Acid

Ishii¹,

Kishi²,

Yamagami³

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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The role of transient receptor potential vanilloid-1 on neural responses to acids by the chorda tympani, glossopharyngeal and superior laryngeal nerves in mice

Cited by 37 publications

References 63 publications

Does laryngopharyngeal reflux cause intraoral burning sensations? A preliminary study

Does laryngopharyngeal reflux cause intraoral burning sensations? A preliminary study

Contribution of the TRPV1 channel to salt taste quality in mice as assessed by conditioned taste aversion generalization and chorda tympani nerve responses

The Use of Mammalian Cultured Cells Loaded with a Fluorescent Dye Shows Specific Membrane Penetration of Undissociated Acetic Acid

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