The Role of Transforming Growth Factor-β in the Regulation of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases by Pancreatic Stellate Cells: Implications for Chronic Pancreatitis

Shek, FW; Fmj, Walker; Pender, S.; Chance, Victoria; Williams, EJ; Johnson, CD; Benyon, R. Christopher; Iredale, JP; Fine,

doi:10.1042/cs103040pb

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Role Of Cafs In Pdac1

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2019

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“…Tumor cells co-cultured with CAFs had a fibroblast-like appearance, increased migration, and expressed mesenchymal markers Vimentin, Snail-1, and Zeb [32]. One proposed mechanism for CAFs-induced EMT involves TGF-β that is highly produced by myofibroblasts [33,34].…”

Section: Role Of Cafs In Pdacmentioning

confidence: 99%

Cancer-Associated Fibroblasts’ Functional Heterogeneity in Pancreatic Ductal Adenocarcinoma

Awaji

Singh

2019

Cancers

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Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related deaths in the USA. Desmoplasia and inflammation are two major hallmarks of PDAC. Desmoplasia, composed of extracellular matrix (ECM), cancer-associated fibroblasts (CAFs), and infiltrating immune and endothelial cells, acts as a biophysical barrier to hinder chemotherapy and actively contributes to tumor progression and metastasis. CAFs represent a multifunctional subset of PDAC microenvironment and contribute to tumor initiation and progression through ECM deposition and remodeling, as well as the secretion of paracrine factors. Attempts to resolve desmoplasia by targeting CAFs can render an adverse outcome, which is likely due to CAFs heterogeneity. Recent reports describe subsets of CAFs that assume more secretory functions, in addition to the typical myofibroblast phenotype. Here, we review the literature and describe the relationship between CAFs and inflammation and the role of the secretory-CAFs in PDAC.

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Section: Role Of Cafs In Pdacmentioning

confidence: 99%

Cancer-Associated Fibroblasts’ Functional Heterogeneity in Pancreatic Ductal Adenocarcinoma

Awaji

Singh

2019

Cancers

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The Role of Transforming Growth Factor-β in the Regulation of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases by Pancreatic Stellate Cells: Implications for Chronic Pancreatitis

Abstract: Conclusions: This is the first demonstration of lymphocyte adhesion supported by a CXC chemokine and suggests that CXCL16 has the ability both to attract and then to retain lymphocytes at epithelial surfaces thereby promoting bile duct damage in inflammatory liver disease.

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Cancer-Associated Fibroblasts’ Functional Heterogeneity in Pancreatic Ductal Adenocarcinoma

Cancer-Associated Fibroblasts’ Functional Heterogeneity in Pancreatic Ductal Adenocarcinoma

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