The role of transferrin saturation as a screening test for hereditary                haemochromatosis in an Irish population seeking medical care

O’Hara, Ryan; Cavanagh, N. P. C.; Cassidy, Michael R.; Cullina, M.J.

doi:10.1258/000456303763046111

Cited by 4 publications

(7 citation statements)

References 31 publications

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“…Although Gonzales et al [1984] previously used human standards to evaluate iron parameters in lemurs, it has never been determined experimentally whether human reference ranges for serum ferritin or %TS can be transferred to lemur species. The %TS value is regarded as a highly reliable diagnostic parameter in human hemochromatosis [O'Hara et al, 2003]; however, a complete investigation of lemur iron status would ideally include serum ferritin and, as a calibrating parameter, a histological evaluation of liver biopsies. While some differential causes for a decreased %TS (e.g., late pregnancy) or an increased %TS (e.g., starvation) could be ruled out for the individuals examined, it was not possible to exclude all differential diagnoses [c.f.…”

Section: Discussionmentioning

confidence: 99%

Increased iron absorption in lemurs: Quantitative screening and assessment of dietary prevention

Wood

Fang

Hunt³

et al. 2003

American J Primatol

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Iron storage disease (ISD) in lemurs has been reported since as early as the 1960s, and in the 1980s was demonstrated to be a consistent finding in postmortem investigations of captive lemurs. Since then this disease has consistently been diagnosed at the point of necropsy. In the current study we describe a preclinical screening procedure, as well as the quantified preventive effects of dietary intervention upon iron absorption. Twenty-three individual lemurs of four species were initially tested with the transferrin saturation test (%TS); 21 of these animals were on conventional zoo diets, and two were fed a specific diabetic diet. Initially, 20 of 21 lemurs on conventional zoo diets were demonstrated to have %TS levels above the normal range for humans; 17 of these lemurs were in the category (for humans) of excessive iron absorption. A dietary change aimed at reducing dietary iron and vitamin C levels and increasing the levels of iron-chelating tannins and/or phytates was instigated. After the animals were retested, a matched-pair comparison of %TS values before and after the diet change revealed significantly (P=0.038, n=7) lower %TS values after the diet change. All species averages were in the human hyperabsorption range on conventional zoo diets (n=21). No species averages were in that range after the dietary change (n=18). The results indicate that further investigations into the use of %TS testing in lemur husbandry, and specific preventive dietary measures, should be conducted.

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Section: Discussionmentioning

confidence: 99%

Increased iron absorption in lemurs: Quantitative screening and assessment of dietary prevention

Wood

Fang

Hunt³

et al. 2003

American J Primatol

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“…13,38,[62][63][64][65][66][67] Six studies were prospective cohort studies, 38,62,63,[65][66][67] with two including a control group. 38,62 The other two studies were a retrospective cohort study 13 and a cross-sectional case-control study.…”

Section: Uk Epidemiology Studiesmentioning

confidence: 99%

“…64 The participants in the studies varied depending upon the rationale for the study, including people diagnosed with haemochromatosis, 13,38,62 people attending a blood donation service, 65,67 those on registers of newborn children 63 or heart attack sufferers, 64 and those attending for routine blood screening. 66 Control groups included healthy blood donors, 38 people registered with general practitioners 64 and people on bone marrow registers.…”

Section: Uk Epidemiology Studiesmentioning

confidence: 99%

“…Prevalence data for the general population originated from several cohorts including healthy blood donors, 38,65,67 a register of newborn children, 63 general practitioner populations, 64 people on bone marrow registers 62 and people providing blood specimens for routine screening. 66 Inevitably the variations in these groups may have some effect on the prevalence rates reported. In the UK studies identified, the prevalence of the C282Y homozygous mutation in the general population ranged from 0.68% 65 to 1.24%, 62 with five studies identifying prevalence rates between 0.9% and 1% (median prevalence 0.97%).…”

mentioning

confidence: 99%

“…In the UK studies identified, the prevalence of the C282Y homozygous mutation in the general population ranged from 0.68% 65 to 1.24%, 62 with five studies identifying prevalence rates between 0.9% and 1% (median prevalence 0.97%). 38,63,64,66,67 Prevalence rates in the UK for the C282Y heterozygous mutation were higher and had a wider range. The prevalence in the five studies ranged from 5.9% in a cohort of healthy blood donors 38 to 19% in a cohort of newborn Irish children.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Diagnostic strategies using DNA testing for hereditary haemochromatosis in at-risk populations: a systematic review and economic evaluation

Bryant

Cooper²,

Picot³

et al. 2009

Health Technol Assess

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Comparison of serum iron, total iron binding capacity, ferritin, and percent transferrin saturation in nine species of apparently healthy captive lemurs

Williams

Campbell

Glenn

2006

American J Primatol

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Lemurs kept in captivity have been reported to be highly prone to accumulate excessive amounts of iron in tissues (hemosiderosis). Diagnosis of the condition is most commonly made during a postmortem examination because an antemortem diagnosis requires a liver biopsy, a procedure that may not be well tolerated by all animals. The lack of a noninvasive method to evaluate iron status in captive lemurs limits investigators' ability to effectively screen animals for the presence of hemosiderosis, and to detect the condition early when treatment protocols are most effective. This study was conducted in an effort to provide data regarding iron analyte values in healthy captive lemurs of multiple species. The relationship of various iron-related metabolites was evaluated in 177 clinically normal lemurs of nine different species. Serum iron (sI), total iron binding capacity (TIBC), and ferritin concentration were measured directly and the percent transferrin saturation (TS) was calculated. Significant differences in various iron metabolites were observed among several species, suggesting that normal reference values for iron metabolites in lemurs may need to be developed on a species by species basis.

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The role of transferrin saturation as a screening test for hereditary haemochromatosis in an Irish population seeking medical care

Cited by 4 publications

References 31 publications

Increased iron absorption in lemurs: Quantitative screening and assessment of dietary prevention

Increased iron absorption in lemurs: Quantitative screening and assessment of dietary prevention

Diagnostic strategies using DNA testing for hereditary haemochromatosis in at-risk populations: a systematic review and economic evaluation

Comparison of serum iron, total iron binding capacity, ferritin, and percent transferrin saturation in nine species of apparently healthy captive lemurs

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