The role of tobacco use on dental care and oral disease severity within community dental clinics in Japan

Ojima, Miki; Hanioka, Takashi; Shimada, Kaoru; Haresaku, Satoru; Yamamoto, Mito; Tanaka, Keiko

doi:10.1186/1617-9625-11-13

Cited by 10 publications

(12 citation statements)

References 29 publications

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“…Along with lung cancer, vascular stenosis, heart attacks and periodontal disease, dental caries has been reported to be associated with smoking all over the world, including Swedish and US smokers, Mexican truck drivers, Turkey and Japanese children, and Italy military personnel (4)(5)(6)(7)(8)(9). A recent study in Japan demonstrated smokers received more caries/endodontic treatment than non-smokers (10).…”

Section: Introductionmentioning

confidence: 99%

Nicotine promotes Streptococcus mutans extracellular polysaccharide synthesis, cell aggregation and overall lactate dehydrogenase activity

Huang

Gregory

2015

Archives of Oral Biology

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Several epidemiology studies have reported a positive relationship between smoking and dental caries. Nicotine, an alkaloid component of tobacco, has been demonstrated to stimulate biofilm formation and metabolic activity of Streptococcus mutans, one of the most important pathogens of dental caries. The first aim of the present study was to explore the possible mechanisms leading to increased biofilm by nicotine treatment from three aspects, extracellular polysaccharides (EPS) synthesis, glucosyltransferase (Gtf) synthesis and glucan-binding protein (Gbp) synthesis at the mRNA and protein levels. The second aim was to investigate how nicotine affects S. mutans virulence, particular in lactate dehydrogenase (LDH) activity. Confocal laser scanning microscopy results demonstrated that both biofilm bacterial cell numbers and EPS were increased by nicotine. Gtf and GbpA protein expression of S. mutans planktonic cells were upregulated while GbpB protein expression of biofilm cells were downregulated by nicotine. The mRNA expression trends of those genes were mostly consistent with results on protein level but not statistically significant, and gtfD and gbpD of biofilm cells were inhibited. Nicotine was not directly involved in S. mutans LDH activity. However, since it increases the total number of bacterial cells in biofilm, the overall LDH activity of S. mutans biofilm is increased. In conclusion, nicotine stimulates S. mutans planktonic cell Gtf and Gbp expression. This leads to more planktonic cells attaching to the dental biofilm. Increased cell numbers within biofilm results in higher overall LDH activity. This contributes to caries development in smokers.

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Section: Introductionmentioning

confidence: 99%

Nicotine promotes Streptococcus mutans extracellular polysaccharide synthesis, cell aggregation and overall lactate dehydrogenase activity

Huang

Gregory

2015

Archives of Oral Biology

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“…25 However, the detrimental effects of smoking may not be clearly realized by dental professionals, unless the smoking status of all patients is identified. 26 Furthermore, as shown by a survey conducted in European dental schools, education opportunities for tobacco cessation should be strengthened within undergraduate dental education 27 and by continuing professional development.…”

Section: Discussionmentioning

confidence: 99%

A national opinion study supports tobacco cessation by oral health professionals in Japan

Nagao

Fukuta

Seto

et al. 2017

Translational Research in Oral Oncology

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Background: Oral health professionals (OHPs) could have an important role in contributing to tobacco-dependence treatment of patients who visit dental clinics. How the public may perceive the role of OHPs in this capacity, however, has not been formally evaluated. The objective of this study was to assess national awareness and receptivity among Japanese in terms of the implementation of tobacco cessation counseling and treatment (TCCT) by OHPs in dental settings covered by National Health Insurance (NHI). The study participants' awareness and knowledge on tobacco-related health disparities were also examined.

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“…, , Ojima et al . ). Finally, two reports concluded that endodontic treatment in smokers had fewer successes (Doyle et al .…”

Section: Association Between Endodontics and Smoking Habitsmentioning

confidence: 97%

“…Ojima et al . () studied the characteristics of dental care of 2835 current smokers and 6850 nonsmokers finding that caries/endodontic treatment were significantly more frequent in smokers compared to nonsmokers (47.1% vs. 43.6%, P = 0.002).…”

Section: Association Between Endodontics and Smoking Habitsmentioning

confidence: 99%

“…The same year, Kirkevang et al (2007) analysed individual and tooth specific factors associated with the incidence or the persistence of AP in a general population, concluding that smoking was a significant risk factor when assessed separately (OR = 1.9; P < 0.05). Ojima et al (2013) studied the characteristics of dental care of 2835 current smokers and 6850 nonsmokers finding that caries/endodontic treatment were significantly more frequent in smokers compared to nonsmokers (47.1% vs. 43.6%, P = 0.002).…”

Section: Studies Finding No Association Between Smoking and Endodontimentioning

confidence: 99%

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Endodontic medicine: connections between apical periodontitis and systemic diseases

2015

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The prevalence of apical periodontitis (AP) in Europe has been reported to affect 61% of individuals and 14% of teeth, and increase with age. Likewise, the prevalence of root canal treatment (RCT) in Europe is estimated to be around 30-50% of individuals and 2-9% of teeth with radiographic evidence of chronic persistent AP in 30-65% of root filled teeth (RFT). AP is not only a local phenomenon and for some time the medical and dental scientific community have analysed the possible connection between apical periodontits and systemic health. Endodontic medicine has developed, with increasing numbers of reports describing the association between periapical inflammation and systemic diseases. The results of studies carried out both in animal models and humans are not conclusive, but suggest an association between endodontic variables, that is AP and RCT, and diabetes mellitus (DM), tobacco smoking, coronary heart disease and other systemic diseases. Several studies have reported a higher prevalence of periapical lesions, delayed periapical repair, greater size of osteolityc lesions, greater likelihood of asymptomatic infections and poorer prognosis for RFT in diabetic patients. On the other hand, recent studies have found that a poorer periapical status correlates with higher HbA1c levels and poor glycaemic control in type 2 diabetic patients. However, there is no scientific evidence supporting a causal effect of periapical inflammation on diabetes metabolic control. The possible association between smoking habits and endodontic infection has also been investigated, with controversial results. The aim of this paper was to review the literature on the association between endodontic variables and systemic health (especially DM and smoking habits).

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The role of tobacco use on dental care and oral disease severity within community dental clinics in Japan

Cited by 10 publications

References 29 publications

Nicotine promotes Streptococcus mutans extracellular polysaccharide synthesis, cell aggregation and overall lactate dehydrogenase activity

Nicotine promotes Streptococcus mutans extracellular polysaccharide synthesis, cell aggregation and overall lactate dehydrogenase activity

A national opinion study supports tobacco cessation by oral health professionals in Japan

Endodontic medicine: connections between apical periodontitis and systemic diseases

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