The role of tissue inhibitor of metalloproteinases in the aetiology of inguinal and incisional hernias

Durukan, Ugur; Ağcaoğlu, Orhan; Ozoran, Emre; Karahan, Salih Nafiz; Özata, İbrahim Halil; Düzköylü, Yiğit; Pasaoglu, Esra; Aren, Acar

doi:10.1111/iwj.13746

Cited by 7 publications

(3 citation statements)

References 27 publications

(51 reference statements)

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“…Biomolecules 2023, 13, x FOR PEER REVIEW 8 of 13 on chromosome 11q22-q23 and their primary function is to cleave collagen types I, II, and III [29]. The involvement of MMP-2 in the pathogenesis of direct IHs is supported by Antoniou et al [11].…”

Section: Mmpsmentioning

confidence: 97%

A Systematic Review on the Role of Matrix Metalloproteinases in the Pathogenesis of Inguinal Hernias

Bracale,

Peltrini,

Iacone

et al. 2023

Biomolecules

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The recurrence rate in patients who undergo surgery for abdominal wall hernias (AWHs) is high. AWHs have been hypothesized to be a disease of the extracellular matrix, which is supported by evidence showing a high incidence of AWHs in patients with connective tissue disorders. This study aimed to investigate the most recent literature studies describing the levels of several matrix metalloproteinases (MMPs) in the blood and fascia, with the objective of better clarifying the pathogenetic role of matrix metalloproteinases (MMPs) and their inhibitors in inguinal hernias (IHs). A systematic literature search was conducted using the PubMed, Scopus, and Web of Science electronic databases to identify eligible studies. The identified studies were included in the analysis, and a qualitative synthesis of the results is provided to describe the most recent findings. Seventeen studies were included. An association between MMP-2 and direct IHs has also been demonstrated. MMP-1, MMP-2, MMP-9, MMP-12, and MMP-13 levels were increased in both the serum and fascia of patients with IHs. The analysis of inhibitors showed an increase in tissue inhibitors of metalloproteinases (TIMPs), specifically TIMP-1 in IHs, particularly in direct hernias, and a reduction in TIMP-2 in the biopsy samples of the transversalis fascia. In contrast, a reduction in TIMP-1 and an increase in TIMP-2 levels have been reported only in the serum of patients with IHs. Metalloproteinases play a crucial role in the pathogenesis of IHs. The analysis of other molecules, such as TIMPs or their correlation with specific genes, is enhancing our understanding of the pathophysiology of IHs. However, more prospective studies, including comprehensive clinical and laboratory data collection, are required to confirm the relationship between the studied biomarkers and the risk of IHs.

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Section: Mmpsmentioning

confidence: 97%

A Systematic Review on the Role of Matrix Metalloproteinases in the Pathogenesis of Inguinal Hernias

Bracale,

Peltrini,

Iacone

et al. 2023

Biomolecules

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“…The values of multiple metalloproteinases were increased in patients with inguinal hernia, while those of TIMPs were decreased (47). Other papers state that only TIMP-2 was decreased, while TIMP-1 was significantly increased or even not significantly different (48) (49). MMP-1 and MMP-13 are enzymes involved in the degradation of types I, II and III collagen and they have been shown to play a role in the pathophysiology of inguinal hernia (49,50).…”

Section: Extracellular Matrix In Patients With Inguinal Herniamentioning

confidence: 99%

“…Other papers state that only TIMP-2 was decreased, while TIMP-1 was significantly increased or even not significantly different (48) (49). MMP-1 and MMP-13 are enzymes involved in the degradation of types I, II and III collagen and they have been shown to play a role in the pathophysiology of inguinal hernia (49,50). However, MMP-2 was found to be the most important metalloproteinase involved in the development of inguinal hernias.…”

Section: Extracellular Matrix In Patients With Inguinal Herniamentioning

confidence: 99%

A Comprehensive Review of Inguinal Hernia Occurrence in Obese Individuals

ROSCA,

PADURARU,

BOLOCAN

et al. 2023

Maedica

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Inguinal hernia repair is one of the most commonly performed surgical activities worldwide. Given the circumstances, understanding and identifying the risk and the protective factors is an essential step in order to prevent, diagnose and treat such a common condition. For a long time, obesity was generally considered to be a risk factor in the occurrence of an inguinal hernia. Studies have provided some unexpected data, suggesting that it might actually be a protective factor. This review aims to provide an overview on this topic, taking into account systemic aspects such as collagen distribution and metabolism. In inguinal hernia patients, the ratio between type I collagen and type III collagen is decreased, with type III collagen being responsible for the weakness of the abdominal wall. In obese patients, the extracellular matrix becomes richer in collagen, especially type I collagen, which will generate strength and stiffness. Obesity seems to be a protective factor indeed, but in order to understand the underlying mechanism and to choose the optimal surgical approach, further research is needed.

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Optimal computed tomography-based biomarkers for prediction of incisional hernia formation

Talwar,

Desai,

McAuliffe

et al. 2023

Hernia

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The role of tissue inhibitor of metalloproteinases in the aetiology of inguinal and incisional hernias

Cited by 7 publications

References 27 publications

A Systematic Review on the Role of Matrix Metalloproteinases in the Pathogenesis of Inguinal Hernias

A Systematic Review on the Role of Matrix Metalloproteinases in the Pathogenesis of Inguinal Hernias

A Comprehensive Review of Inguinal Hernia Occurrence in Obese Individuals

Optimal computed tomography-based biomarkers for prediction of incisional hernia formation

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