The Role of Tissue Doppler Imaging in the Noninvasive Detection of Chronic Rejection after Heterotopic Cardiac Transplantation in Rats

Jassal, Davinder S.; Othman, Rgia A.; Ahmadie, Roien; Fang, Tielan; Zieroth, Shelley; Fischer, Gábor; Moghadasian, Mohammed H.

doi:10.1111/j.1540-8175.2008.00751.x

Cited by 10 publications

(3 citation statements)

References 30 publications

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“…In a study published in 2009, tissue Doppler imaging was able to show for the first time a correlation between systolic radial strain rate in the anterior wall and rejection grade but no correlation with ejection fraction during chronic rejection in a heterotopic rat cardiac transplant model although ejection fraction was clearly decreased at all grades of histological rejection 23. This was followed by another study using a different technique of magnetic resonance strain imaging that showed decreased circumferential strain despite normal ejection fraction in a rat heart-lung transplant model 24.…”

Section: Discussionmentioning

confidence: 97%

Speckle-tracking 2-dimensional strain echocardiography: A new noninvasive imaging tool to evaluate acute rejection in cardiac transplantation

Pieper

Shah

Harmann

et al. 2010

The Journal of Heart and Lung Transplantation

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Section: Discussionmentioning

confidence: 97%

Speckle-tracking 2-dimensional strain echocardiography: A new noninvasive imaging tool to evaluate acute rejection in cardiac transplantation

Pieper

Shah

Harmann

et al. 2010

The Journal of Heart and Lung Transplantation

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“…We can conclude that the role of assessment of filling pressure in a transplanted heart is limited regarding detect rejection. There are some reports on the use of myocardial deformation imaging that are promising but still echocardiography cannot replace endomyocardial biopsies for surveillance of rejection . Second, the easily obtained echocardiographic assessment of filling pressures could help the clinician to adjust diuretics that are commonly used in HTx recipients, especially in the first year post transplant until the heart fully recovers.…”

Section: Discussionmentioning

confidence: 99%

Echocardiography Detects Elevated Left Ventricular Filling Pressures in Heart Transplant Recipients

et al. 2014

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Diastolic dysfunction is a recognized complication in heart transplant (HTx) recipients that limits exercise capacity and is a risk factor for mortality. We investigated the ability of echocardiography to detect elevated pulmonary capillary wedge pressure (mean PCWP>15 mmHg) in HTx recipients. This retrospective study comprised HTx recipients with echocardiography and right heart catheterization within 24 hours (n = 100, 113 investigations). Echocardiographic assessment was performed using mitral inflow (E/A ratio, deceleration time [DT], isovolumic relaxation time [IVRT]), tissue Doppler (E/E' lateral) parameters, and the Doppler-estimated pulmonary artery systolic pressure (Doppler PASP). The right atrial pressure (RAP) was estimated based on size and the effect of respiration or sniffing on the inferior vena cava diameter. Cutoff values were determined from a derivation group (n = 57, receiver operator characteristic curve analysis) and evaluated in a test group (n = 56). Elevated PCWP were found in 38%. The RAP and PCWP were both normal in 58 investigations and elevated in 39 investigations (concordance rate of 86.6%). The presence of signs of increased RAP by echocardiography or with three of five parameters (E/A, DT, IVRT, E/E' lateral, and Doppler PASP) reaching the cutoff values ruled in elevated PCWP with positive likelihood ratios ranging from 15.3 to 9. With normal RAP by echocardiography or none of the other parameters reaching cutoff values elevated PCWP can be ruled out with negative likelihood ratios ranging from 0.07 to 0.19. In conclusion, elevated PCWP in HTx recipients can be assessed using echocardiography.

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“…Transthoracic Echo was done on all animals at baseline, 3 days, 2 weeks, 4 weeks, and 16 weeks post‐surgery as described previously (Jassal et al, 2009 ; Kaur et al, 2006 ). The parameters measured included: heart rate (HR), left ventricular end diastolic diameter (LVEDd), LV end systolic diameter (LVEDs), and LV ejection fraction (LVEF).…”

Section: Methodsmentioning

confidence: 99%

Olive oil protects against progression of heart failure by inhibiting remodeling of heart subsequent to myocardial infarction in rats

Al‐Shudiefat

Malik

Jassal

et al. 2022

Physiological Reports

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We examined the beneficial effects of olive oil against heart failure post‐myocardial infarction (PMI), induced by coronary artery ligation in rats. Animals were divided into sham and ligated groups and fed either regular chow, olive oil (10% wt/wt), or corn oil (10% wt/wt) and were followed up to 16 weeks. On the echocardiography at 3 days (PMI), in the ligated regular chow (LRC), ligated olive oil (LOO), and ligated corn oil (LCO) left ventricular ejection fraction (LVEF) decrease was 12.14%, 16.42%, and 17.53% from the baseline, respectively. However, only LOO group improved LVEF significantly at 16 weeks PMI and became comparable with all sham groups. Both scar formation and collagen deposition at 16 weeks PMI were less pronounced in the LOO group. Myocardial TNF‐α level at 4 weeks of PMI increased by 176%, 11%, and 181% in the LRC, LOO, and LCO groups, respectively. Plasma TNF‐α levels in LOO were significantly lower than LRC group after 4 weeks of PMI. Myocardial redox ratio (reduced glutathione/oxidized glutathione) decreased at 4 weeks PMI by 44.4%, 16.4%, and 36.9% in the LRC, LOO, and LCO groups, respectively, compared to the baseline. These changes in the redox ratio at 16 weeks PMI were further exacerbated in the LRC and LCO groups. Lipid hydroperoxides formation increased at 4 weeks PMI by 137.4%, 14.6%, and 97.1% in the LRC, LOO, and LCO groups, respectively. Since coronary artery ligation decreased left ventricular ejection fraction, increased myocardial TNF‐α and oxidative stress, and since olive oil was able to inhibit these effects, it is proposed that dietary olive oil modulates cardiac remodeling and heart failure subsequent to myocardial infarction.

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The Role of Tissue Doppler Imaging in the Noninvasive Detection of Chronic Rejection after Heterotopic Cardiac Transplantation in Rats

Abstract: TDI of the transplanted heart in rats is feasible, reproducible, and more sensitive than palpation for the detection of chronic rejection.

Cited by 10 publications

References 30 publications

Speckle-tracking 2-dimensional strain echocardiography: A new noninvasive imaging tool to evaluate acute rejection in cardiac transplantation

Speckle-tracking 2-dimensional strain echocardiography: A new noninvasive imaging tool to evaluate acute rejection in cardiac transplantation

Echocardiography Detects Elevated Left Ventricular Filling Pressures in Heart Transplant Recipients

Olive oil protects against progression of heart failure by inhibiting remodeling of heart subsequent to myocardial infarction in rats

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