The Role of Thiol on Degradation of Pentaerythrityl Tetranitrate and Isosorbide Dinitrate

Suwitono, Marvel Reuben; Kartasasmi, Rahmana Emran; Pamudji, J.S; Ibrahim, Samir

doi:10.3923/jas.2011.3854.3859

Cited by 1 publication

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“…isosorbide dinitrate (ISDN), isosorbide mononitrate (ISMN), pentaerythrityl dinitrate (PEDN), and pentaerythrityl mononitrate (PEMN) (Münzel et al, 2011). Due to lack of technical aspect to detect direct NO, as well as for quantification of NO as primary product in the reaction of nitrate and thiol, thus, analysis is being focuses on its donor as indirect measurement of NO levels (Suwitono et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Kinetic Analysis on Decomposition of Pentaerythrityl Tetranitrate under Influence of Thiols

Suwitono

Kartasasmita²,

Pamudji³

et al. 2019

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Pentaerythrityl tetranitrate (PETN) is an organic nitrate compound used in the therapy asgeneral vasodilator in the treatment of angina pectoris. PETN acts as prodrug for nitric oxideas active component. However, in clinical association, it is known a decreased ability oforganic nitrate to do chemical reduction, which is metabolic tolerance, by upregulation inendogenic thiol system. It has been proved that supplementation of thiol is able to overcometolerance to nitrate, nevertheless there is no comprehensive reports on interaction betweenorganic nitrate and thiol compounds. The goal of this research is to study decompositionreaction kinetic of PETN under influence N-acetyl cysteine (NAC) and thiosalicylic acid(TSA) as thiol compounds, in the physiological condition. PETN as tracing compound weremonitored by chromatographic system, with ratio of thiols used was equal, doubled, fivetimes, and ten times folds. Data were analyzed kinetically by using math equation for reactionorder 1, 2, and composite order 1 (equivalence). The result showed the linearity values onkinetic derivative, where correlation coefficient, r, is higher than 0.9 (r ≥ 0.9) for compositeorder 1. The result will give scientific contribution about tolerance phenomena in organicnitrate, particularly in the role of thiol compound to overcome nitrate tolerance.

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Section: Introductionmentioning

confidence: 99%