The role of thiamine in HIV infection

Lương, Khanh vinh quốc; Nguyễn, Lan

doi:10.1016/j.ijid.2012.11.019

Cited by 21 publications

(8 citation statements)

References 127 publications

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“…The expression of VEGF-C is associated with high-risk HPV infection of cervical lesions, with linearly increasing expression starting from low-grade CIN, which can be used as an early marker of cervical cancer [ 42 ]. The literature on the role of thiamine in HIV infection suggests that thiamine affects HIV through matrix metalloproteinase (MMP), vascular endothelial growth factor (VEGF), and cyclooxygenase 2(COX-2), and thiamine supplementation may be beneficial to AIDS patients [ 43 ]. Interestingly, HIV seropositivity is closely related to the high incidence rate of HPV and the high prevalence of HPV polygenic infection [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Thiamine Intake with Human Papillomavirus (HPV) Infection in American Women: A Secondary Data Analysis Based on the National Health and Nutrition Examination Survey from 2003 to 2016

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Association of Thiamine Intake with Human Papillomavirus (HPV) Infection in American Women: A Secondary Data Analysis Based on the National Health and Nutrition Examination Survey from 2003 to 2016

et al. 2020

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“…2E & 3B). The upregulation of this pathway may directly inhibit the activities of p53 function 65 and other cellular relevant functions 66 , leading to the reduction of apoptosis in tumor cells. Pantothenate metabolism was only affected in the responder group in both treatments (p<0.01; Fig.…”

Section: Discussionmentioning

confidence: 99%

Genome-scale Pathway Flux Analysis Predicts Efficacy of anti-PD-1 Therapy in Melanoma

Mei¹,

Du²,

Halfter³

et al. 2020

Preprint

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Background: Currently, predicting treatment efficacy to immunotherapy has been under extensive investigation. However, a putative biomarker for immunotherapy in melanoma remains to be found.Methods: Utilizing genetic data from two independent melanoma patient cohorts treated with anti-PD-1 therapy, the study described herein conducted a genome-scale pathway flux analysis (GPFA) and related statistical methods to determine whether specific pathways could be identified that are relevant to immunotherapy efficacy.Results: The analysis results highlighted three mechanisms responsible for the efficacy of immunotherapy in melanoma including 1) proper cellular functions in immune cells; 2) angiogenesis for the development and differentiation of immune cells; 3) energy metabolic remodeling to meet the activation of immune cells. Based on these discoveries, a pathway flux-based biomarker (IM.Index) was developed and assessed to validate its predictive ability with odds ratio (OR) of 3.14 (95%CI: 1.16-8.45; p=3.10E-3), sensitivity 76% and specificity 89%. The IM.Index achieved an objective response rate (ORR) of 70%. Comparison to other four putative biomarkers (TMB, NAL, neo-peptide load and cytolytic score) showed a comparative outcome with an hazard ratio (HR) of 1.83 (95%CI: 1.26-2.67; p=1.62E-3) and area under curve (AUC) of 0.82.Conclusion: These results indicate a translational potential of IM.Index, as a biomarker, for anti-PD-1 therapy in melanoma and the GPFA might pave a new path for biomarker discovery in immunotherapy.

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“…The therapeutic applications of V B1 have extended to the prevention of immune HIV-associated complications. V B1 exerts beneficial effects in HIV patients through the protein expression of vascular endothelial growth factor and matrix metalloproteinase [103, 104]. In the present study, the physiological outcome of V B1 treatment in M. bovis BCG was examined by both transcriptomic and metabolomic analyses.…”

Section: Discussionmentioning

confidence: 99%

The prominent alteration in transcriptome and metabolome of Mycobacterium bovis BCG str. Tokyo 172 induced by vitamin B1

Song¹,

Li²,

Cui³

et al. 2019

BMC Microbiol

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Background Vitamin B 1 (V B1 ) is a crucial dietary nutrient and essential cofactor for several key enzymes in the regulation of cellular and metabolic processes, and more importantly in the activation of immune system. To date, the precise role of V B1 in Mycobacterium tuberculosis remains to be fully understood. Results In this study, the transcriptional and metabolic profiles of V B1 -treated Mycobacterium. bovis BCG were analyzed by RNA-sequencing and LC-MS (Liquid chromatography coupled to mass spectrometry). The selection of BCG strain was based on its common physiological features shared with M. tuberculosis . The results of cell growth assays demonstrated that V B1 inhibited the BCG growth rate in vitro. Transcriptomic analysis revealed that the expression levels of genes related to fatty acid metabolism, cholesterol metabolism, glycolipid catabolism, DNA replication, protein translation, cell division and cell wall formation were significantly downregulated in M. bovis BCG treated with V B1. In addition, the metabolomics LC-MS data indicated that most of the amino acids and adenosine diphosphate (ADP) were decreased in M. bovis BCG strain after V B1 treatment. Conclusions This study provides the molecular and metabolic bases to understand the impacts of V B1 on M.bovis BCG . Electronic supplementary material The online version of this article (10.1186/s12866-019-1492-9) contains supplementary material, which is available to authorized users.

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The role of thiamine in HIV infection

Cited by 21 publications

References 127 publications

Association of Thiamine Intake with Human Papillomavirus (HPV) Infection in American Women: A Secondary Data Analysis Based on the National Health and Nutrition Examination Survey from 2003 to 2016

Association of Thiamine Intake with Human Papillomavirus (HPV) Infection in American Women: A Secondary Data Analysis Based on the National Health and Nutrition Examination Survey from 2003 to 2016

Genome-scale Pathway Flux Analysis Predicts Efficacy of anti-PD-1 Therapy in Melanoma

The prominent alteration in transcriptome and metabolome of Mycobacterium bovis BCG str. Tokyo 172 induced by vitamin B1

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