The role of the vertebral venous system in the metastasis of cancer to the spinal column.Experiments with tumor-cell suspensions in rats and rabbits

Coman, Dale Rex; Delong, Robert P.

doi:10.1002/1097-0142(195105)4:3<610::aid-cncr2820040312>3.0.co;2-q

Cited by 151 publications

(37 citation statements)

References 2 publications

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“…This might be explained by assuming that the posteriorly located basivertebral vein serves as an entrance site for hematogenous spread of metastases [6][7][8].…”

Section: Discussionmentioning

confidence: 99%

Do metastases in vertebrae begin in the body or the pedicles? Imaging study in 45 patients.

Algra¹,

Heimans²,

Valk³

et al. 1992

American Journal of Roentgenology

162

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To establish the initial location of metastases within vertebrae and to determine the association between pedicle destruction and involvement of other parts of the vertebra by metastases, we performed a retrospective analysis of CT and plain film findings in patients in whom spinal metastases were identified for the first time.The location of destruction seen on CT was compared with the location of destruction seen on plain films. Special attention was paid to the location of destruction seen on CT in patients in whom destruction of a pedicle was seen on plain films.We tested the hypothesis that the observed location of vertebral destruction followed the sites of entry of the vertebral vessels. Materials and MethodsDuring the years i 987-i 989, 20i patients in our hospital were examined radiologically for skeletal metastases.From this group, we selected 86 patients in whom symptoms and/or signs of vertebral metastases were identified for the first time, and in whom both CT scans and plain films of the spine were obtained within a period of i week (maximum interval between both examinations, 7 days; average, 2.i days). We excluded from evaluation 4i Downloaded from www.ajronline.org by 54.245.13.81 on 05/11/18 from IP address 54.245.13.81.

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“…This might be explained by assuming that the posteriorly located basivertebral vein serves as an entrance site for hematogenous spread of metastases [6][7][8].…”

Section: Discussionmentioning

confidence: 99%

Do metastases in vertebrae begin in the body or the pedicles? Imaging study in 45 patients.

Algra¹,

Heimans²,

Valk³

et al. 1992

American Journal of Roentgenology

162

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“…8 Coman and Delong noted metastasis involving the vertebrae in 70 % of mice when malignant cells were injected in femoral veins of rats with application of abdominal pressure. 9 These experimental models suggest that tumors can spread through Batson's plexus. 9 Venous air embolism during spinal surgery 12 and dissemination of infections have also been attributed to the VVS.…”

Section: Discussionmentioning

confidence: 99%

“…9 These experimental models suggest that tumors can spread through Batson's plexus. 9 Venous air embolism during spinal surgery 12 and dissemination of infections have also been attributed to the VVS. For example, infections of the urinary tract and after prostatic surgery can spread to the spine causing osteomyelitis.…”

Section: Discussionmentioning

confidence: 99%

Metastasis of lung cancer through Batson’s plexus: very rare but possible

Panikkath

Radhi²,

Lim³

et al. 2013

SW Resp Crit Care Chron

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Many malignancies, like prostate, colon, and breast cancer, metastasize throughBatson’s plexus (vertebral venous plexus). Although lung cancer is one of the mostcommon cancers in the United States, its spread through Batson’s plexus is consideredextremely rare. We report a 76-year-old woman with adenocarcinoma of the lung whohad metastasis affecting multiple contiguous vertebral bodies likely due to disseminationthrough Batson’s plexus of veins. This plexus is a component of the cerebrospinalvenous system (CSVS) consisting of the cranial venous system and the vertebralvenous plexus (Batson’s plexus). The CSVS is a valveless network of veins which areimportant in the venous drainage of the brain and spine. However, this venous networkprovides an easy channel for the dissemination of infections and malignant cells.

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“…Three methods have been reported for the experimental epidural tumor causing cord compression: 1) injection of Walker 256 carcinoma cells into the tail vein (Coman and DeLong 1951). 2 ) transplantation of Murphy-Sturni lymphoma into the nape of the neck (Rubin 1969).…”

Section: Discussionmentioning

confidence: 99%