The role of the ventrolateral frontal cortex in inhibitory oculomotor control

Hodgson, Timothy L.; Chamberlain, Marcia; Parris, Benjamin A.; James, Martin; Gutowski, Nicholas J.; Husain, Masud; Kennard, Christopher

doi:10.1093/brain/awm064

Cited by 86 publications

(75 citation statements)

References 55 publications

(63 reference statements)

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“…The similarity between this finding and previous results using an infrared eye tracker, [11][12][13]33 along with the strong correlation of performance on the BAS and our laboratory AS task, further underscores the validity of the task. Impaired AS performance is correlated with structural alterations to the right greater than left premotor regions of the frontal lobes in focal lesion patients, 34 neurodegenerative disease, 12 psychiatric illness, 35 and normal aging. 4,36 Our results suggest that the BAS may be sensitive to damage to these same brain regions and could be used as a screen for such damage at the bedside.…”

Section: Resultsmentioning

confidence: 98%

Multicenter validation of a bedside antisaccade task as a measure of executive function

Hellmuth¹,

Mirsky²,

Heuer³

et al. 2012

Neurology

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Objective: To create and validate a simple, standardized version of the antisaccade (AS) task that requires no specialized equipment for use as a measure of executive function in multicenter clinical studies. Methods:The bedside AS (BAS) task consisted of 40 pseudorandomized AS trials presented on a laptop computer. BAS performance was compared with AS performance measured using an infrared eye tracker in normal elders (NE) and individuals with mild cognitive impairment (MCI) or dementia (n ϭ 33). The neuropsychological domain specificity of the BAS was then determined in a cohort of NE, MCI, and dementia (n ϭ 103) at UCSF, and the BAS was validated as a measure of executive function in a 6-center cohort (n ϭ 397) of normal adults and patients with a variety of brain diseases.

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Section: Resultsmentioning

confidence: 98%

Multicenter validation of a bedside antisaccade task as a measure of executive function

Hellmuth¹,

Mirsky²,

Heuer³

et al. 2012

Neurology

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“…Importantly, the network described above may be effector independent, because preSMA, IFC, and the STN are also recruited by NoGo or stopping studies that have examined the control of eye movements (Stuphorn and Schall, 2006;Chikazoe et al, 2007;Hodgson et al, 2007;Isoda and Hikosaka, 2007a,b) and speech (Xue et al, 2006).…”

Section: Resultsmentioning

confidence: 99%

Converging Evidence for a Fronto-Basal-Ganglia Network for Inhibitory Control of Action and Cognition: Figure 1.

Aron¹,

Durston²,

Eagle³

et al. 2007

J. Neurosci.

484

376

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“…Further, a recent lesion study in humans has shown that the rFIC has an important role in cognitive control related to task switching. Using an oculomotorswitching task Hodgson and colleagues (45) showed that patients with lesions in the anterior rFIC were the most impaired in altering their behavior in accordance with the changing rules of the task. In normal healthy adults, functional brain imaging studies have suggested that the FIC and the ACC are together involved in a variety of cognitive control processes, including conflict and error monitoring, interference resolution, and response selection (23,36,40,(46)(47)(48).…”

Section: Differential Roles Of the Rfic Acc And Lateral Prefrontal mentioning

confidence: 99%

A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks

Sridharan

Levitin

Menon

2008

Proc. Natl. Acad. Sci. U.S.A.

2,495

213

2,236

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Cognitively demanding tasks that evoke activation in the brain's central-executive network (CEN) have been consistently shown to evoke decreased activation (deactivation) in the default-mode network (DMN). The neural mechanisms underlying this switch between activation and deactivation of large-scale brain networks remain completely unknown. Here, we use functional magnetic resonance imaging (fMRI) to investigate the mechanisms underlying switching of brain networks in three different experiments. We first examined this switching process in an auditory event segmentation task. We observed significant activation of the CEN and deactivation of the DMN, along with activation of a third network comprising the right fronto-insular cortex (rFIC) and anterior cingulate cortex (ACC), when participants perceived salient auditory event boundaries. Using chronometric techniques and Granger causality analysis, we show that the rFIC-ACC network, and the rFIC, in particular, plays a critical and causal role in switching between the CEN and the DMN. We replicated this causal connectivity pattern in two additional experiments: (i) a visual attention ''oddball'' task and (ii) a task-free resting state. These results indicate that the rFIC is likely to play a major role in switching between distinct brain networks across task paradigms and stimulus modalities. Our findings have important implications for a unified view of network mechanisms underlying both exogenous and endogenous cognitive control.brain networks ͉ cognitive control ͉ insula ͉ attention ͉ prefrontal cortex O ne distinguishing feature of the human brain, compared with brains lower on the phylogenetic ladder, is the amount of cognitive control available for selecting, switching, and attending to salient events in the environment. Recent research suggests that the human brain is intrinsically organized into distinct functional networks that support these processes (1-4). Analysis of resting-state functional connectivity, using both model-based and model-free approaches, has suggested the existence of at least three canonical networks: (i) a centralexecutive network (CEN), whose key nodes include the dorsolateral prefrontal cortex (DLPFC), and posterior parietal cortex (PPC); (ii) the default-mode network (DMN), which includes the ventromedial prefrontal cortex (VMPFC) and posterior cingulate cortex (PCC); and (iii) a salience network (SN), which includes the ventrolateral prefrontal cortex (VLPFC) and anterior insula (jointly referred to as the fronto-insular cortex; FIC) and the anterior cingulate cortex (ACC) (1, 2, 4, 5). During the performance of cognitively demanding tasks, the CEN and SN typically show increases in activation whereas the DMN shows decreases in activation (1, 2, 6). However, what remains unknown is the crucial issue of how the operation of these networks, identified in the resting state, relate to their function during cognitive information processing. Furthermore, the cognitive control mechanisms that mediate concurrent activation and deactiva...

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The role of the ventrolateral frontal cortex in inhibitory oculomotor control

Cited by 86 publications

References 55 publications

Multicenter validation of a bedside antisaccade task as a measure of executive function

Multicenter validation of a bedside antisaccade task as a measure of executive function

Converging Evidence for a Fronto-Basal-Ganglia Network for Inhibitory Control of Action and Cognition: Figure 1.

A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks

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