The role of the universal sugar transport system components PtsI (EI) and PtsH (HPr) in Enterococcus faecium
Michelle Hallenbeck,
Michelle Chua,
James Collins
Abstract:Vancomycin-resistant enterococci (VRE) pose a serious threat to public health because of their limited treatment options. Therefore, there is an increasing need to identify novel targets to develop new drugs. Here, we examined the roles of the universal PTS components, PtsI and PtsH, in Enterococcus faecium to determine their roles in carbon metabolism, biofilm formation, stress response, and the ability to compete in the gastrointestinal tract. Clean deletion of ptsHI resulted in a significant reduction in th… Show more
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