The role of the ubiquitin-proteasome pathway in skin cancer development: 26S proteasome-activated NF-κB signal transduction

Cui

Contrast Media & Molecular Imaging

et al. 2022

In order to investigate the effects of different doses of Dahuang Zhechong pills on the ubiquitin proteasome pathway/nuclear factor-κB (UPP-NF-κB) in rats with atherosclerosis (AS), 58-week-old male Wistar rats were selected and randomly divided into the normal group, model group, control group, low-dose group, and high-dose group. The model group and the drug group are given intraperitoneal injections of vitamins, and the model group and the drug group are given a high-fat diet. Rats in the low-dose group and high-dose group are given low-dose and high-dose Dahuang Zhechong pill lavage solution, respectively. Besides, the control group is given simvastatin solution by gavage, and intervention is performed once a day for 12 weeks. Ubiquitin (Ub) protein expression, ubiquitin activase (UBE1), nuclear factor-κB, nuclear inhibitory factor-κB (IκB) gene expression, total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and serum tumor necrosis factor-α (TNF-α) are compared. The experimental result shows that Dahuang Zhechong pills can reduce inflammation and prevent and treat AS by blocking the activation of the UPP/NF-κB signaling pathway and can be used as a proteasome inhibitor in the clinical treatment of AS.

Section: Related Workmentioning

confidence: 99%

[Retracted] Study on the Effects of Different Doses of Dahuang Zhechong Pills on the Ubiquitin Proteasome Pathway/Nuclear Factor‐κB in Rats with Atherosclerosis and Its Mechanism

Cui

Contrast Media & Molecular Imaging

et al. 2022

“…71,171,174,200 As mentioned above, studies on cancer cells have indicated that cancerous cells are far more susceptible to proteosome suppression than normal cells. [201][202][203][204][205] This opens opportunities to design compounds which preferentially bind to proteasomes.…”

Section: Perspective Dalton Transactionsmentioning

confidence: 99%

Addressing the gaps in homeostatic mechanisms of copper and copper dithiocarbamate complexes in cancer therapy: a shift from classical platinum-drug mechanisms

et al. 2023

“…Author details 1 Laboratory of Biochemistry, Environment and Agrifood (URAC 36), Faculty of Science and Technology, Mohammedia-University Hassan II of Casablanca, Mohammedia, Morocco. 2 Hematology and Pediatric Oncology Service-Hospital August 20, UniversityHospital Center IBN ROCHD Casablanca, Casablanca, Morocco. 3 National Institute of Social Actions (INAS), Tanger, Morocco.…”

Section: Author Contributionsmentioning

confidence: 99%

“…It adapts to its environment by producing new proteins and renewing or eliminating obsolete or defective proteins [1]. Indeed, intracellular proteolysis is involved in the elimination of abnormal proteins, in the supply of amino acids required for the synthesis of novel proteins in the context of metabolic control, in the maturation of polypeptide precursors [2,3], in the immune response through the production of peptides presented on the cell surface by the major histocompatibility complex class I, and also in proliferation and programmed cell death [4]. To date, lysosomes, calpain, caspases and the ubiquitin-proteasome system are the four main intracellular proteolytic systems [5].…”

Section: Introductionmentioning

confidence: 99%

Functional and quantitative evaluation of the 20S proteasome in serum and intracellular in145 moroccan patients with hematologic malignancies

et al. 2022

Self Cite

Background Regulatory degradation of intracellular proteins plays an essential role in most biological processes, particularly in the control of cell proliferation and differentiation. In eukaryotes, intracellular proteolysis is largely provided by the Ubiquitin / Proteasome system. Alterations and dysfunction of protein degradation by the Ubiquitin / Proteasome system, such as transcription factors, cell cycle regulators or tumor suppressor proteins, have been linked to human. Pathologies, including blood cancers. Mainly localized in the nucleus and cytoplasm of cells, the proteasome can be detected in the cell culture supernatant or in the peripheral blood of patients. This study deals with the problems of the search for serum markers specific to certain pathologies and which would be useful in the prevention, diagnosis and monitoring of cancers and which could be used as a therapeutic tool. Methods The functional and quantitative analysis of the proteasome is carried out at the serum and subcellular level during a pathological phenomenon in a population of 145 Moroccan patients (sex ratio: 1.10 / average age: 47.9 ± 15, 3 years) using an indirect ELISA test and a follow-up of the fluorescence emitted after enzymatic digestion of specific peptides by proteolytic activity (chymotrypsin-like). Results The evolutionary trend proteasome subcellular is significantly linked to the rate of chymotrypsin-like activity. The entire population of 60 patients called back for a second blood test. After three months of treatment reported a significant drop in the rate and the activity of the proteasome in serum and intracellular level. Conclusions Although the serum proteasome level is a potential new tool for the monitoring of. Patientswithliquid cancer. Trial registration: retrospectively registered.