The role of the supplementary motor area for speech and language processing

Hertrich, Ingo; Dietrich, Susanne; Ackermann, Hermann

doi:10.1016/j.neubiorev.2016.06.030

Cited by 219 publications

(147 citation statements)

References 166 publications

Supporting

Mentioning

130

Contrasting

Unclassified

Order By: Relevance

“…Although the phonological regressor is built on a level of annotation that is close to the actual perceptual structure of the words, it is not directly built on the auditory properties of the stimulus, making these observed results both surprising and interesting. In addition to this, the phonological stream activates the supplementary motor area (SMA), which has been suggested to be involved not only in speech production [41], but also in speech processing [42, 43]. Phoneme perplexity did not return activation in the premotor cortex, an area that has been associated with speech production and perception.…”

Section: Discussionmentioning

confidence: 99%

Using stochastic language models (SLM) to map lexical, syntactic, and phonological information processing in the brain

et al. 2017

View full text Add to dashboard Cite

Language comprehension involves the simultaneous processing of information at the phonological, syntactic, and lexical level. We track these three distinct streams of information in the brain by using stochastic measures derived from computational language models to detect neural correlates of phoneme, part-of-speech, and word processing in an fMRI experiment. Probabilistic language models have proven to be useful tools for studying how language is processed as a sequence of symbols unfolding in time. Conditional probabilities between sequences of words are at the basis of probabilistic measures such as surprisal and perplexity which have been successfully used as predictors of several behavioural and neural correlates of sentence processing. Here we computed perplexity from sequences of words and their parts of speech, and their phonemic transcriptions. Brain activity time-locked to each word is regressed on the three model-derived measures. We observe that the brain keeps track of the statistical structure of lexical, syntactic and phonological information in distinct areas.

show abstract

Section: Discussionmentioning

confidence: 99%

Using stochastic language models (SLM) to map lexical, syntactic, and phonological information processing in the brain

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The SMA has a known role in the preparation and initiation of voluntary movements, including speech (Duffy, 2013). Specifically, the SMA has been implicated in the transition between the conceptualization of a word to different aspects of speech production, including articulation and prosody (Hertrich, Dietrich, & Ackermann, 2016). In addition to experimental findings, theories of speech motor control also recognize the SMA as influencing the initiation of speech (Tourville & Guenther, 2011).…”

Section: Discussionmentioning

confidence: 99%

Prosodic and phonetic subtypes of primary progressive apraxia of speech

et al. 2018

View full text Add to dashboard Cite

Primary progressive apraxia of speech (PPAOS) is a clinical syndrome in which apraxia of speech is the initial indication of neurodegenerative disease. Prior studies of PPAOS have identified hypometabolism, grey matter atrophy, and white matter tract degeneration in the frontal gyri, precentral cortex, and supplementary motor area (SMA). Recent clinical observations suggest two distinct subtypes of PPAOS may exist. Phonetic PPAOS is characterized predominantly by distorted sound substitutions. Prosodic PPAOS is characterized predominantly by slow, segmented speech. Demographic, clinical, and neuroimaging data (MRI, DTI, and FDG-PET) were analyzed to validate these subtypes and explore anatomic correlates. The Phonetic subtype demonstrated bilateral involvement of the SMA, precentral gyrus, and cerebellar crus. The Prosodic subtype demonstrated more focal involvement in the SMA and right superior cerebellar peduncle. The findings provide converging evidence that differences in the reliably determined predominant clinical characteristics of AOS are associated with distinct imaging patterns, independent of severity.

show abstract

“…Furthermore, pre-SMA and SMA also contribute to motor learning, speech and language processing (Seitz et al 2006; Kim and Shin 2014; Hertrich et al 2016). Interestingly, pre-SMA and SMA also mediate motor inhibition (Toma et al 1999; Li et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Cytoarchitecture, probability maps, and functions of the human supplementary and pre-supplementary motor areas

et al. 2018

View full text Add to dashboard Cite

The dorsal mesial frontal cortex contains the supplementary motor area (SMA) and the pre-supplementary motor area (pre-SMA), which play an important role in action and cognition. Evidence from cytoarchitectonic, stimulation, and functional studies suggests structural and functional divergence between the two subregions. However, a microstructural map of these areas obtained in a representative sample of brains in a stereotaxic reference space is still lacking. In the present study we show that the dorsal mesial frontal motor cortex comprises two microstructurally different brain regions: area SMA and area pre-SMA. Area-specific cytoarchitectonic patterns were studied in serial histological sections stained for cell bodies of ten human postmortem brains. Borders of the two cortical areas were identified using image analysis and statistical features. The 3D reconstructed areas were transferred to a common reference space, and probabilistic maps were calculated by superimposing the individual maps. A coordinate-based meta-analysis of functional imaging data was subsequently performed using the two probabilistic maps as microstructurally defined seed regions. It revealed that areas SMA and pre-SMA were strongly co-activated with areas in precentral, supramarginal and superior frontal gyri, Rolandic operculum, thalamus, putamen and cerebellum. Both areas were related to motor functions, but area pre-SMA was involved in more complex processes such as learning, cognitive processes and perception. The here described subsequent analyses led to converging evidence supporting the microstructural, and functional segregation of areas SMA and pre-SMA, and maps will be made available to the scientific community to further elucidate the microstructural substrates of motor and cognitive control.Electronic supplementary materialThe online version of this article (10.1007/s00429-018-1738-6) contains supplementary material, which is available to authorized users.

show abstract

The role of the supplementary motor area for speech and language processing

Cited by 219 publications

References 166 publications

Using stochastic language models (SLM) to map lexical, syntactic, and phonological information processing in the brain

Using stochastic language models (SLM) to map lexical, syntactic, and phonological information processing in the brain

Prosodic and phonetic subtypes of primary progressive apraxia of speech

Cytoarchitecture, probability maps, and functions of the human supplementary and pre-supplementary motor areas

Contact Info

Product

Resources

About