The role of the sub-thalamic nucleus in the preparation of volitional movement termination in Parkinson's disease

Kuo, Yi-Hsuan; Lai, Hsin Yi; Chang, Yao-Chuan; Chiou, Shang Ming; Lu, Ming-Kuei; Lin, Yu Chin; Liu, Chia‐Jyi; Chen, Chiung Chu; Chien, Ting Fang; Lin, Shinn Zong; Tsai, Chon Haw

doi:10.1016/j.expneurol.2011.10.013

Cited by 11 publications

(9 citation statements)

References 33 publications

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“…Crenna et al (2006) indicated that the STN stimulation changed the start of gait dynamics. The clinical study in patients with Parkinson's disease indicated that the STN stimulation played a role in the termination of voluntary movement (Hsu et al 2012). The results of the present study, however, indicated that the decreased gait speed of bradykinesia correlates with the unsynchronized off-/onlatency interval, which is due to the excessive long tonic EMG activity of the soleus muscle in the advanced stages of the disease (Fig.…”

Section: Off-latencycontrasting

confidence: 57%

Gait bradykinesia in Parkinson’s disease: a change in the motor program which controls the synergy of gait

et al. 2017

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Section: Off-latencycontrasting

confidence: 57%

Gait bradykinesia in Parkinson’s disease: a change in the motor program which controls the synergy of gait

et al. 2017

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“…The degree of improvement in motor symptoms (bradykinesia and rigidity) correlates with the degree of beta band suppression (Weinberger et al, 2006 ; Ray et al, 2008 ; Kuhn et al, 2009 ). Lastly, in the STN, beta ERD occurs upon movement initiation and heightened synchronization occurs upon termination of movements (Alegre et al, 2005 ; Hsu et al, 2012 ). As expected, we found excessive beta band activity at rest in our PD subjects with lower power HFOs across a broad range.…”

Section: Discussionmentioning

confidence: 99%

GPi Oscillatory Activity Differentiates Tics from the Resting State, Voluntary Movements, and the Unmedicated Parkinsonian State

et al. 2016

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Background: Deep brain stimulation (DBS) is an emerging treatment strategy for severe, medication-refractory Tourette syndrome (TS). Thalamic (Cm-Pf) and pallidal (including globus pallidus interna, GPi) targets have been the most investigated. While the neurophysiological correlates of Parkinson's disease (PD) in the GPi and subthalamic nucleus (STN) are increasingly recognized, these patterns are not well characterized in other disease states. Recent findings indicate that the cross-frequency coupling (CFC) between beta band and high frequency oscillations (HFOs) within the STN in PD patients is pathologic.Methods: We recorded intraoperative local field potentials (LFPs) from the postero-ventrolateral GPi in three adult patients with TS at rest, during voluntary movements, and during tic activity and compared them to the intraoperative GPi-LFP activity recorded from four unmedicated PD patients at rest.Results: In all PD patients, we noted excessive beta band activity (13–30 Hz) at rest which consistently modulated the amplitude of the co-existent HFOs observed between 200 and 400 Hz, indicating the presence of beta-HFO CFC. In all 3TS patients at rest, we observed theta band activity (4–7 Hz) and HFOs. Two patients had beta band activity, though at lower power than theta oscillations. Tic activity was associated with increased high frequency (200–400 Hz) and gamma band (35–200 Hz) activity. There was no beta-HFO CFC in TS patients at rest. However, CFC between the phase of 5–10 Hz band activity and the amplitude of HFOs was found in two TS patients. During tics, this shifted to CFC between the phase of beta band activity and the amplitude of HFOs in all subjects.Conclusions: To our knowledge this is the first study that shows that beta-HFO CFC exists in the GPi of TS patients during tics and at rest in PD patients, and suggests that this pattern might be specific to pathologic/involuntary movements. Furthermore, our findings suggest that during tics, resting state 5–10 Hz-HFO CFC shifts to beta-HFO CFC which can be used to trigger stimulation in a closed loop system when tics are present.

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“…A beta ERD was observed during movement initiation and ERS during movement termination [16,33,34,35]. Moreover, when patients were cued not to move following movement preparation, a significant synchronization was observed in the beta-frequency band [20,21,22,36].…”

Section: Lfp and Parkinson's Diseasementioning

confidence: 99%

“…Although the presence of 64 contacts would render current programming methods impractical, novel analytic methods based on LFPs have been developed to assess spatial reach and efficacy of DBS stimulation [79]. The use of LFPs in improving DBS clinical outcomes has largely been explored in the setting of DBS implantation into STN for the treatment of PD [30,35,80,81]. Recent work in STN LFP analysis suggests that programming could be improved through analysis of macroelectrode-recorded LFPs and modeling of stimulation parameters [79,82,83].…”

Section: Current and Prospective Clinical Applications Of Lfp Recordingmentioning

confidence: 99%

Clinical Implications of Local Field Potentials for Understanding and Treating Movement Disorders

Thompson

Lanctin

Ince

et al. 2014

Stereotact Funct Neurosurg

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Background: Deep brain stimulation (DBS) for the treatment of movement disorders has provided researchers with an opportunity to record electrical oscillatory activity from electrodes implanted in deep brain structures. Extracellular activity recorded from a population of neurons, termed local field potentials (LFPs), has shed light on the pathophysiology of movement disorders and holds the potential to lead to refinement in existing treatments. Objective: This paper reviews the clinical significance of LFPs recorded from macroelectrodes implanted in basal ganglia and thalamic targets for the treatment of Parkinson's disease, essential tremor and dystonia. Methods: Neural population dynamics and subthreshold events, which are undetectable by single-unit recordings, can be examined with frequency band analysis of LFPs (frequency range: 1-250 Hz). Results: Of clinical relevance, reliable correlations between motor symptoms and components of the LFP power spectrum suggest that LFPs may serve as a biomarker for movement disorders. In particular, Parkinson's rigidity has been shown to correlate with the power of beta oscillations (13-30 Hz), and essential tremor coheres with oscillations of 8-27 Hz. Furthermore, evidence indicates that the optimal contacts for DBS programming can be predicted from the anatomic location of beta and gamma bands (48-200 Hz). Conclusion: LFP analysis has implications for improved electrode targeting and the development of a real-time, individualized, ‘closed-loop' stimulation system.

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The role of the sub-thalamic nucleus in the preparation of volitional movement termination in Parkinson's disease

Cited by 11 publications

References 33 publications

Gait bradykinesia in Parkinson’s disease: a change in the motor program which controls the synergy of gait

Gait bradykinesia in Parkinson’s disease: a change in the motor program which controls the synergy of gait

GPi Oscillatory Activity Differentiates Tics from the Resting State, Voluntary Movements, and the Unmedicated Parkinsonian State

Clinical Implications of Local Field Potentials for Understanding and Treating Movement Disorders

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