The role of the stress system in recovery after traumatic brain injury: A tribute to Bruce S. McEwen

Weil, Zachary M.; White, Brishti A.; Whitehead, Bailey; Karelina, Kate

doi:10.1016/j.ynstr.2022.100467

Cited by 12 publications

(7 citation statements)

References 222 publications

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“…Approximately every second, TBI patient encounters physical and/or psychological impairments in their daily life post‐TBI 67 . Stress encountered before TBI might negatively or positively affect the outcomes and recovery after TBI 68 . Of note, sham mice received sham surgery, anesthesia, and analgesia (see materials & methods) thereby raising baseline stress levels (Figure 3).…”

Section: Discussionmentioning

confidence: 99%

“…In this study, AS pre‐exposure negatively influenced the TBI‐induced weight loss, while it positively affected beam balancing (NSS) and the time per run in the ladder walk in both sexes (Figure 1). Thus, AS pre‐exposure influences TBI‐induced behavioral changes in both a beneficial and unfavorable manner 68 …”

Section: Discussionmentioning

confidence: 99%

“…Thus, AS pre-exposure influences TBI-induced behavioral changes in both a beneficial and unfavorable manner. 68 Interestingly, in the OF and Y maze, the influence of AS on a subsequent TBI was sex-specific (Figure 1D,E). In the OF, both sexes responded to AS + TBI by increasing their track length in the OF.…”

Section: Tbi-associated Behaviormentioning

confidence: 91%

“…67 Stress encountered before TBI might negatively or positively affect the outcomes and recovery after TBI. 68 Of note, sham mice received sham surgery, anesthesia, and analgesia (see materials & methods) thereby raising baseline stress levels (Figure 3). Thus, compared to completely untreated mice, sham mice might already have some behavioral alterations (e.g., weight loss, track length; Figure 1).…”

Section: Tbi-associated Behaviormentioning

confidence: 99%

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Acute stress modulates the outcome of traumatic brain injury‐associated gene expression and behavioral responses

Reiners,

Leopold,

Hallebach

et al. 2023

The FASEB Journal

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Psychological stress and traumatic brain injury (TBI) result in long‐lasting emotional and behavioral impairments in patients. So far, the interaction of psychological stress with TBI not only in the brain but also in peripheral organs is poorly understood. Herein, the impact of acute stress (AS) occurring immediately before TBI is investigated. For this, a mouse model of restraint stress and TBI was employed, and their influence on behavior and gene expression in brain regions, the hypothalamic–pituitary–adrenal (HPA) axis, and peripheral organs was analyzed. Results demonstrate that, compared to single AS or TBI exposure, mice treated with AS prior to TBI showed sex‐specific alterations in body weight, memory function, and locomotion. The induction of immediate early genes (IEGs, e.g., c‐Fos) by TBI was modulated by previous AS in several brain regions. Furthermore, IEG upregulation along the HPA axis (e.g., pituitary, adrenal glands) and other peripheral organs (e.g., heart) was modulated by AS–TBI interaction. Proteomics of plasma samples revealed proteins potentially mediating this interaction. Finally, the deletion of Atf3 diminished the TBI‐induced induction of IEGs in peripheral organs but left them largely unaltered in the brain. In summary, AS immediately before brain injury affects the brain and, to a strong degree, also responses in peripheral organs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Tbi-associated Behaviormentioning

confidence: 91%

Section: Tbi-associated Behaviormentioning

confidence: 99%

See 2 more Smart Citations

Acute stress modulates the outcome of traumatic brain injury‐associated gene expression and behavioral responses

Reiners,

Leopold,

Hallebach

et al. 2023

The FASEB Journal

View full text Add to dashboard Cite

show abstract

“…Stress compromises post-injury recovery; however, TBI also impedes recovery from stress. 31 This delayed resolution of stress could thus create a feed-forward cycle of dysfunctional stress response and post-injury consequences. Pre-clinical psychosocial stress has lasting effects by sensitizing neuroinflammatory and behavioral responses to subsequent stressors.…”

Section: Introductionmentioning

confidence: 99%

Divergent Spatial Learning, Enhanced Neuronal Transcription, and Blood–Brain Barrier Disruption Develop During Recovery from Post-Injury Sleep Fragmentation

Tapp,

Ren,

Palmer

et al. 2023

Neurotrauma Reports

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Traumatic brain injury (TBI) causes pathophysiology that may significantly decrease quality of life over time. A major propagator of this response is chronic, maladaptive neuroinflammation, which can be exacerbated by stressors such as sleep fragmentation (SF). This study determined whether post-TBI SF had lasting behavioral and inflammatory effects even with a period of recovery. To test this, male and female mice received a moderate lateral fluid percussion TBI or sham surgery. Half the mice were left undisturbed, and half were exposed to daily SF for 30 days. All mice were then undisturbed between 30 and 60 days post-injury (DPI), allowing mice to recover from SF (SF-R). SF-R did not impair global Barnes maze performance. Nonetheless, TBI SF-R mice displayed retrogression in latency to reach the goal box within testing days. These nuanced behavioral changes in TBI SF-R mice were associated with enhanced expression of neuronal processing/signaling genes and indicators of blood–brain barrier (BBB) dysfunction. Aquaporin-4 (AQP4) expression, a marker of BBB integrity, was differentially altered by TBI and TBI SF-R. For example, TBI enhanced cortical AQP4 whereas TBI SF-R mice had the lowest cortical expression of perivascular AQP4, dysregulated AQP4 polarization, and the highest number of CD45 + cells in the ipsilateral cortex. Altogether, post-TBI SF caused lasting, divergent behavioral responses associated with enhanced expression of neuronal transcription and BBB disruption even after a period of recovery from SF. Understanding lasting impacts from post-TBI stressors can better inform both acute and chronic post-injury care to improve long-term outcome post-TBI.

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Special issue dedicated to Dr. Bruce S. McEwen

Hill

Hunter

Reagan

2023

Neurobiology of Stress

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The role of the stress system in recovery after traumatic brain injury: A tribute to Bruce S. McEwen

Cited by 12 publications

References 222 publications

Acute stress modulates the outcome of traumatic brain injury‐associated gene expression and behavioral responses

Acute stress modulates the outcome of traumatic brain injury‐associated gene expression and behavioral responses

Divergent Spatial Learning, Enhanced Neuronal Transcription, and Blood–Brain Barrier Disruption Develop During Recovery from Post-Injury Sleep Fragmentation

Special issue dedicated to Dr. Bruce S. McEwen

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