The Role of the Stolviach Wall in the Exogenous Development of Plasmodium Galllnaceum as Studied by Means of Haelviocoel Injections of Susceptible and Refractory Mosquitoes

Weathersby, A. B.

doi:10.1093/infdis/91.2.198

Cited by 51 publications

(13 citation statements)

References 5 publications

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“…Ookinetes injected into the hemocoel of mosquitoes (161, 164) or even the hemocoel of Drosophila melanogaster (105) can attach to the midgut wall and transform into oocysts that subsequently develop into sporozoites. Ookinetes can also transform in vitro into oocysts and develop sporozoites in the presence of matrigel, which includes a laminin-like substrate (3).…”

Section: Mosquito Stage Development and Generation Of Sporozoitesmentioning

confidence: 99%

Malaria Parasite Development in the Mosquito and Infection of the Mammalian Host

Aly

Vaughan

Kappe

2009

Annu. Rev. Microbiol.

253

224

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Plasmodium sporozoites are the product of a complex developmental process in the mosquito vector and are destined to infect the mammalian liver. Attention has been drawn to the mosquito stages and preerythrocytic stages owing to recognition that these are bottlenecks in the parasite life cycle and that intervention at these stages can block transmission and prevent infection. Parasite progression in the Anopheles mosquito, sporozoite transmission to the mammalian host by mosquito bite, and subsequent infection of the liver are characterized by extensive migration of invasive stages, cell invasion, and developmental changes. Preparation for the liver phase in the mammalian host begins in the mosquito with an extensive reprogramming of the sporozoite to support efficient infection and survival. Here, we discuss what is known about the molecular and cellular basis of the developmental progression of parasites and their interactions with host tissues in the mosquito and during the early phase of mammalian infection.

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Section: Mosquito Stage Development and Generation Of Sporozoitesmentioning

confidence: 99%

Malaria Parasite Development in the Mosquito and Infection of the Mammalian Host

Aly

Vaughan

Kappe

2009

Annu. Rev. Microbiol.

253

224

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“…It has been known for several decades that parasites injected into the haemocoel can develop further upon binding onto the mosquito midgut wall (Weathersby, 1952;Warburg and Schneider, 1993), and this was confirmed in a dramatic way when it was shown that the injection of parasites into Drosophila melanogaster also leads to the development of infective sporozoites within oocysts attached to the basal lamina at multiple sites, not just the midgut (Schneider and Shahabuddin, 2000). Thus, binding of the ookinete to the basal lamina is a condition that supports its development into a functional oocyst, as demonstrated with the critical requirement of Matrigel in the successful culture of Plasmodium berghei in vitro (Al-Olayan et al, 2002).…”

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confidence: 99%

Laminin and the malaria parasite's journey through the mosquito midgut

Arrighi

Lycett

Mahairaki

et al. 2005

Journal of Experimental Biology

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During the invasion of the mosquito midgut epithelium, Plasmodium ookinetes come to rest on the basal lamina, where they transform into the sporozoite-producing oocysts. Laminin, one of the basal lamina's major components, has previously been shown to bind several surface proteins of Plasmodium ookinetes. Here, using the recently developed RNAi technique in mosquitoes, we used a specific dsRNA construct targeted against the LANB2 gene (laminin γ1) of Anopheles gambiae to reduce its mRNA levels, leading to a substantial reduction in the number of successfully developed oocysts in the mosquito midgut. Moreover, this molecular relationship is corroborated by the intimate association of developing P. berghei parasites and laminin in the gut, as observed using confocal microscopy. Our data support the notion of laminin playing a functional role in the development of the malaria parasite within the mosquito midgut.

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“…The accumulation of actin around the parasite at the time of egress has been also noted (Vernick et al, 1995; Whitten et al, 2006). The interaction of the extracellular ookinete with the basal lamina is believed to induce transformation to the oocyst stage (Weathersby, 1952). The passage of an individual ookinete is thought to take no more than 30 min.…”

Section: The Cell Biology Of Malaria Parasite Invasion Of Mosquitomentioning

confidence: 99%

Invasion of mosquito salivary glands by malaria parasites: Prerequisites and defense strategies

Mueller

Kohlhepp

Hammerschmidt

et al. 2010

International Journal for Parasitology

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The interplay between vector and pathogen is essential for vector-borne disease transmission. Dissecting the molecular basis of refractoriness of some vectors may pave the way to novel disease control mechanisms. A pathogen often needs to overcome several physical barriers, such as the peritrophic matrix, midgut epithelium and salivary glands. Additionally, the arthropod vector elicites immune responses that can severely limit transmission success. One important step in the transmission of most vector-borne diseases is the entry of the disease agent into the salivary glands of its arthropod vector. The salivary glands of blood-feeding arthropods produce a complex mixture of molecules that facilitate blood feeding by inhibition of the host haemostasis, inflammation and immune reactions. Pathogen entry into salivary glands is a receptor-mediated process, which requires molecules on the surface of the pathogen and salivary gland. In most cases, the nature of these molecules remains unknown. Recent advances in our understanding of malaria parasite entry into mosquito salivary glands strongly suggests that specific carbohydrate molecules on the salivary gland surface function as docking receptors for malaria parasites.

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The Role of the Stolviach Wall in the Exogenous Development of Plasmodium Galllnaceum as Studied by Means of Haelviocoel Injections of Susceptible and Refractory Mosquitoes

Cited by 51 publications

References 5 publications

Malaria Parasite Development in the Mosquito and Infection of the Mammalian Host

Malaria Parasite Development in the Mosquito and Infection of the Mammalian Host

Laminin and the malaria parasite's journey through the mosquito midgut

Invasion of mosquito salivary glands by malaria parasites: Prerequisites and defense strategies

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