2010
DOI: 10.1007/978-3-642-14541-4_5
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The Role of the Sodium-Taurocholate Cotransporting Polypeptide (NTCP) and of the Bile Salt Export Pump (BSEP) in Physiology and Pathophysiology of Bile Formation

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Cited by 243 publications
(270 citation statements)
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References 343 publications
(301 reference statements)
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“…For example, NTCP is a secondary active, electrogenic transporter that mediates substrate uptake by utilizing the electrochemical sodium gradient across the basolateral plasma membrane of hepatocytes (Stieger, 2011). This driving force is maintained by the (Na+K)-ATPase, which requires a continuous supply of ATP.…”
Section: Importance Of Transport Mechanismmentioning
confidence: 99%
See 1 more Smart Citation
“…For example, NTCP is a secondary active, electrogenic transporter that mediates substrate uptake by utilizing the electrochemical sodium gradient across the basolateral plasma membrane of hepatocytes (Stieger, 2011). This driving force is maintained by the (Na+K)-ATPase, which requires a continuous supply of ATP.…”
Section: Importance Of Transport Mechanismmentioning
confidence: 99%
“…J Pharmacol Exp Ther 276, 891-896. Extensive information on the known functional variants of the transporters can be found in (Stieger and Meier, 2011) except for 1 (Kalliokoski and Niemi, 2009) and 2 (Stieger, 2011).…”
Section: Referencesmentioning
confidence: 99%
“…Among these, the sodium taurocholate cotransporter polypeptide (NTCP; SLC10A1) is a major BA uptake transporter in the liver that preferentially moves conjugated BA into mature hepatocytes in a sodium‐dependent manner 3, 4, 5. In humans, NTCP accounts for more than 80% of the hepatic uptake of bile salts (Na + ‐dependent pathway) 6, 7, 8. Alternatively, isoforms of the organic anion transporting polypeptides multispecific transporter family compensate for NTCP deficiency by internalizing conjugated and unconjugated BA (Na + ‐independent pathway) 9, 10.…”
mentioning
confidence: 99%
“…Finally, NTCP, which predominantly transports glycine and taurine conjugated bile salt uptake system, and to a lesser degree also some drugs such as for example rosuvastatin [18].…”
Section: Drug Transporters In the Livermentioning
confidence: 99%
“…The prototypic, endogenous substrates of the enterohepatic circulation are bile salts [16][17][18]. Bile salts are bile acids conjugated with taurine or glycine.…”
Section: Introductionmentioning
confidence: 99%