The Role of the SLC Transporters Protein in the Neurodegenerative Disorders

Abstract

The solute carrier (SLC) superfamily is one of the major subgroups of membrane proteins in mammalian cells. The solute carrier proteins include more than 400 different membrane-spanning solute carriers organized with 65 families in the human. In solute carrier family neurons, neurotransmitter is considered to be a pharmacological target of neuropsychiatric drugs because of their important role in the recovery of neurotransmitters such as GABA, glutamate, serotonin, dopamine and noradrenaline and regulation of their concentration in synaptic regions. Therefore, solute carrier transporters play vital and different roles in neurodegenerative disorders. In this article, the role of solute carrier transporters in neurodegenerative disorders such as Alzheimer disease, amyotrophic lateral sclerosis, Huntington disease, Parkinson's diseases, depression, post-traumatic stress disorder, dementia, schizophrenia, and Epilepsy reviewed and discussed to see how defects or absences in SLC transporter cause neurodegenerative disorders. In this review, we try to summarize what is known about solute carriers with respect to brain distribution and expression. The review summarizes current knowledge on the roles of solute carrier transporters in neurodegenerative disorders.

A Systematic Review of Genomic Regions and Candidate Genes Underlying Behavioral Traits in Farmed Mammals and Their Link with Human Disorders

“…Furthermore, five genes presented a power of Fisher’s exact test for the allele frequency between more docile and more temperamental breed groups higher than 80% ( Table S10B ). Therefore, similar to observed in humans for neurodegenerative disorders [ 138 ], we suggest that genes from the solute carrier family might play an important role in behavioral traits.…”

Brain Age Estimation at Tract Group Level and its Association with Daily Life Measures, Cardiac Risk Factors and Genetic Variants

“…SLC17A2 is one of the solute carrier family that is membrane protein and transporter. It was associated with neurodegenerative disorders because of its important role in the recovery of neurotransmitters 59 . Despite the fact that the associations of SNPs and brain-PAD in other tract groups did not pass the significance threshold, many of them did pass the threshold for suggestive significant association (p < 5E-5).…”

Transcriptional Pathology Evolves Over Time in Rat Hippocampus Following Lateral Fluid Percussion Traumatic Brain Injury

“…There was also a small number of genes (n = 9) that were downregulated early, but were even further diminished at the two-week time point including Adra2a, Ccdc33, Dpp10, Fdft1, Hmcn1, Klhl14, Slc38a4, Tacr3, and Tfrc. Each of these genes have been reported as downregulated in models of chronic neurodegenerative disease such as Alzheimer's and Parkinson's 41,42,51,52,[43][44][45][46][47][48][49][50] .…”