The role of the signaling pathway FGF/FGFR in pancreatic cancer

Gnatenko, D. A.; Копанцев, Е. П.

doi:10.1134/s1990750817020032

Cited by 3 publications

(2 citation statements)

References 47 publications

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“…The fibroblast growth factors (FGFs) include about 23 known proteins and their receptors are associated with PC playing a role in tissue hyperplasia, transition of EMT, tumor metastasis, and angiogenesis ( 70 ). FGF is overexpressed in PC and promotes cell growth, proliferation, and invasion ( 71 , 72 ).…”

Section: Growth Factors and Chemoresistancementioning

confidence: 99%

Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance

et al. 2021

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Pancreatic cancer is one of the most deadly cancers, ranking amongst the top leading cause of cancer related deaths in developed countries. Features such as dense stroma microenvironment, abnormal signaling pathways, and genetic heterogeneity of the tumors contribute to its chemoresistant characteristics. Amongst these features, growth factors have been observed to play crucial roles in cancer cell survival, progression, and chemoresistance. Here we review the role of the individual growth factors in pancreatic cancer chemoresistance. Importantly, the interplay between the tumor microenvironment and chemoresistance is explored in the context of pivotal role played by growth factors. We further describe current and future potential therapeutic targeting of these factors.

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Section: Growth Factors and Chemoresistancementioning

confidence: 99%

Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance

et al. 2021

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“…7C displays the up-and downregulation of most differentially expressed genes in Zeb1 þ/þ and Zeb1 þ/À mPSCs. Those pathways include genes controlling the expression of soluble cues reportedly involved in the paracrinal regulation of oncogenic Ras signaling in cancer cells, such as members belonging to Wnt (39,40), IGF-1 (41), FGF (42), and EGF (43-45) signaling pathways. The manifest downregulation of these genes in Zeb1 þ/À mPSCs supports our data showing the boosting effect of tumor Ras activity elicited by conditioned media of Zeb1-expressing mPSC and underscore the non-cellautonomous control exerted by Zeb1 on pancreatic tumor growth.…”

Section: Zeb1 Expression In Mpscs Regulates Key Signaling Pathways Inmentioning

confidence: 99%

Zeb1 in Stromal Myofibroblasts Promotes Kras-Driven Development of Pancreatic Cancer

Sangrador¹,

Molero

Campbell

et al. 2018

Cancer Research

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The transcription factor Zeb1 has been identified as a crucial player in Kras-dependent oncogenesis. In pancreatic ductal adenocarcinoma (PDAC), Zeb1 is highly expressed in myofibroblasts and correlates with poor prognosis. As Kras mutations are key drivers in PDAC, we aimed here to assess the necessity of Zeb1 for Kras-driven PDAC and to define the role of Zeb1-expressing myofibroblasts in PDAC development. Genetically engineered mice with conditional pancreatic and mutations (KPC) were crossed with haploinsufficient mice (Z). Extensive PDAC was prominent in all 20-week-old KPC;Z mice, whereas only low-grade precursor lesions were detected in age-matched KPC;Z littermates, with PDAC developing eventually in KPC;Z aged animals. Zeb1 expression in myofibroblasts occurred early in tumorigenesis and haploinsufficiency retarded native expansion of stromal myofibroblasts during precursor-to-cancer progression. downregulation in mPSC repressed their activated gene profile, impaired their migratory and proliferative activity, and attenuated their tumor-supporting features. Conditioned media from Z mouse-activated (myofibroblast-like) pancreatic stellate cells (mPSC) boosted Ras activity in pancreatic cancer cells carrying mutant ; this effect was not observed when using conditioned media from Z mPSC, revealing a paracrinal cooperative axis between Zeb1-expressing PSC and oncogenic Kras-bearing tumor cells. We conclude that Zeb1-expressing stromal myofibroblasts enable a heterotypic collaboration with the Kras-fated epithelial compartment, thus supporting pancreatic malignancy. Zeb1 expression in stromal myofibroblasts supports PDAC development via collaboration with the epithelial compartment bearing oncogenic Kras mutations. .

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New path to treating pancreatic cancer: TRAIL gene delivery targeting the fibroblast-enriched tumor microenvironment

Jiang

Wang

Zhou

et al. 2018

Journal of Controlled Release

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The role of the signaling pathway FGF/FGFR in pancreatic cancer

Cited by 3 publications

References 47 publications

Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance

Targeting Growth Factor Signaling Pathways in Pancreatic Cancer: Towards Inhibiting Chemoresistance

Zeb1 in Stromal Myofibroblasts Promotes Kras-Driven Development of Pancreatic Cancer

New path to treating pancreatic cancer: TRAIL gene delivery targeting the fibroblast-enriched tumor microenvironment

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