Abstract:<p>Knockout of the serotonin reuptake transporter (SERT) in murine animals has been shown to model various neuropsychiatric disorders such as major depressive disorder, autism spectrum disorder, and substance use disorder. Moreover, evidence suggests that abnormalities in glutamatergic synapses at the level of dendritic spines may be involved in the aetiology of these disorders. This thesis investigated the extent to which the SERT knockout model adequately parallels dendritic spine abnormalities associa… Show more
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