The role of the serotonin transporter polymorphism for the endocrine stress response in newborns

Mueller, Anett; Brocke, Burkhard; Fries, Eva; Lesch, Klaus‐Peter; Kirschbaum, Clemens

doi:10.1016/j.psyneuen.2009.07.002

Cited by 77 publications

(55 citation statements)

References 51 publications

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“…Indeed, Taylor et al (2006) made a similar observation with respect to homozygous S allele carriers, noting that in benign environments, their genotype assumes properties that protect from depression, relative to L allele carriers (Taylor et al, 2006). Contradictory, recent results showed that newborns with two S alleles have been found to show the highest response after a physical stressor (Mueller et al, 2010).…”

Section: -Httlpr Sles and Stressmentioning

confidence: 70%

“…For example, Jabbi et al (2007) and Gotlib et al (2008) found larger cortisol responses to a stressor in homozygous carriers of the S allele (Gotlib et al, 2008;Jabbi et al, 2007). We recently reported that newborns with two S alleles exhibit the highest cortisol response after a physical stressor (Mueller et al, 2010). In contrast, Alexander et al (2009) and Wüst et al (2009) did not find significant differences in cortisol reactivity between 5-HTTLPR groups after a stressful task.…”

Section: -Httlpr Sles and Stressmentioning

confidence: 77%

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Interaction of Serotonin Transporter Gene-Linked Polymorphic Region and Stressful Life Events Predicts Cortisol Stress Response

Mueller

Armbruster

Moser

et al. 2011

Neuropsychopharmacol

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There has been significant controversy whether stressful life events (SLEs) experienced over the lifespan may elevate the risk of depression in individuals who are homozygous for the short (S) allele of the repeat length polymorphism (5-HTTLPR) in the regulatory region of the serotonin transporter gene (SLC6A4), compared with individuals homozygous for the long (L) allele. On the basis of the hypothesis that age may be a critical variable, by which such a gene-by-environment interaction may be present in younger adults, but not in older adults and in children, aim of this study was to investigate the role of 5-HTTLPR and SLEs on the endocrine stress response in multiple age cohorts. A total of 115 children (8-12 years), 106 younger adults (18-31 years), and 99 older adults (54-68 years) were subjected to the Trier Social Stress Test (TSST) and structured interviews on SLEs. The TSST induced significant endocrine stress responses in all groups. There was a main effect of genotype in younger and older adults with individuals homozygous for the more active L allele showing a significantly larger cortisol response to the TSST than individuals carrying at least one of the low-expressing S alleles. As predicted, there was a significant interaction of 5-HTTLPR genotype and SLEs, but this interaction was only significant in younger adults and only when the measured SLEs had occurred during the first 5 years of life, suggesting that both age and the specific type of SLE has a role in whether a significant gene-environment interaction is observed.

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Section: -Httlpr Sles and Stressmentioning

confidence: 70%

Section: -Httlpr Sles and Stressmentioning

confidence: 77%

Interaction of Serotonin Transporter Gene-Linked Polymorphic Region and Stressful Life Events Predicts Cortisol Stress Response

Mueller

Armbruster

Moser

et al. 2011

Neuropsychopharmacol

Self Cite

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show abstract

“…A large body of research demonstrates a relationship between variations in 5-HTTLPR and the degree of the endocrine stress response (O'Hara andHallmayer, 2007, Caspi et al, 2010). Interestingly, a higher cortisol response in s-allele carriers has been observed in healthy newborns (Mueller et al, 2010). Similarly, the serotonin transporter gene has been shown to modulate the effect of childhood trauma on cognitive function in patients with a psychotic illness, where patients carrying the ss genotype were more vulnerable to the negative 59 effect of trauma than ll and sl carriers (Aas et al, 2012a).…”

Section: Genetic Factors and Early Adversitymentioning

confidence: 99%

The neural diathesis-stress model of schizophrenia revisited: An update on recent findings considering illness stage and neurobiological and methodological complexities

Pruessner

Cullen

Aas

et al. 2017

Neuroscience & Biobehavioral Reviews

251

178

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. (2017). The neural diathesis-stress model of schizophrenia revisited: An update on recent findings considering illness stage and neurobiological and methodological complexities. Neuroscience and biobehavioral reviews, 73, 191-218. https://doi.org/10. 1016/j.neubiorev.2016.12.013 Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections. General rightsCopyright and moral rights for the publications made accessible in the Research Portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognize and abide by the legal requirements associated with these rights.•Users may download and print one copy of any publication from the Research Portal for the purpose of private study or research.•You may not further distribute the material or use it for any profit-making activity or commercial gain •You may freely distribute the URL identifying the publication in the Research Portal Take down policy If you believe that this document breaches copyright please contact librarypure@kcl.ac.uk providing details, and we will remove access to the work immediately and investigate your claim.

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“…These experimental studies provide additional evidence in support of the gene-environment interaction, by finding that the 5-HTTLPR short allele is associated with attentional bias toward threatening stimuli 19,20 and stronger reactivity of cortisol to experimental stressors. 21,22 Examination of published meta-analyses…”

Section: Contribution Of Objective and Experimental Studiesmentioning

confidence: 99%

The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update

2009

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An updated review of 34 human observational studies indicates that the length polymorphism of the serotonin transporter gene moderates the effect of environmental adversity in the development of depression. This finding depends on the use of contextual or objective methods to assess environmental adversity and is attenuated when self-report instruments are used. Inconsistent findings in male adolescents suggest a developmental stage and sex-specific protective mechanism. These systematic relationships between method and results should be followed up to specify causal mechanisms leading to depression.

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The role of the serotonin transporter polymorphism for the endocrine stress response in newborns

Cited by 77 publications

References 51 publications

Interaction of Serotonin Transporter Gene-Linked Polymorphic Region and Stressful Life Events Predicts Cortisol Stress Response

Interaction of Serotonin Transporter Gene-Linked Polymorphic Region and Stressful Life Events Predicts Cortisol Stress Response

The neural diathesis-stress model of schizophrenia revisited: An update on recent findings considering illness stage and neurobiological and methodological complexities

The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update

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