The role of the right hemisphere in semantic control: A case-series comparison of right and left hemisphere stroke

Thompson, Hannah E.; Henshall, Lauren; Jefferies, Elizabeth

doi:10.1016/j.neuropsychologia.2016.02.030

Cited by 26 publications

(22 citation statements)

References 124 publications

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“…By now a sizeable body of convergent patient, fMRI, and TMS evidence supports a role for bilateral ventrolateral prefrontal and temporoparietal cortex in shaping or regulating which aspects of meaning are retrieved in both verbal and non-verbal semantic tasks (Badre and Wagner, 2007;Noonan et al, 2009;Thompson-Schill et al, 1997;Thompson et al, 2016;Whitney et al, 2011a). Recent investigations have SOCIAL SEMANTICS 10 therefore begun to tease apart the individual contributions of these regions to semantic control and establish the extent to which they are distinct from domain-general executive processes (Davey et al, 2016;Devlin et al, 2003;Gough et al, 2005;Noonan et al, 2013).…”

Section: Social Semanticsmentioning

confidence: 99%

“…A third influence on future research is the potential for the CSC framework to pathology, while semantic control impairments arise following frontal and/or temporoparietal damage (Jefferies and Lambon Ralph, 2006;Thompson et al, 2016). It might also be interesting to consider whether future research might similarly dissociate social disorders on the basis of representation versus control impairments.…”

Section: How Can the Csc Framework Guide Future Social Cognition Resementioning

confidence: 99%

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Social Semantics: The role of conceptual knowledge and cognitive control in a neurobiological model of the social brain

Binney

Ramsey

2020

Neuroscience & Biobehavioral Reviews

119

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Research in social neuroscience has primarily focused on carving up cognition into distinct pieces, as a function of mental process, neural network or social behaviour, while the need for unifying models that span multiple social phenomena has been relatively neglected. Here we present a novel framework that treats social cognition as a case of semantic cognition, which provides a neurobiologically constrained and generalizable framework, with clear, testable predictions regarding sociocognitive processing in the context of both health and disease. According to this framework, social cognition relies on two principal systems of representation and control. These systems are neuroanatomically and functionally distinct, but interact to (1) enable development of foundational, conceptual-level knowledge and (2) regulate access to this information in order to generate flexible and context-appropriate social behaviour. The Social Semantics framework shines new light on the mechanisms of social information processing by maintaining as much explanatory power as prior models of social cognition, whilst remaining simpler, by virtue of relying on fewer components that are "tuned" towards social interactions.

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Section: Social Semanticsmentioning

confidence: 99%

Section: How Can the Csc Framework Guide Future Social Cognition Resementioning

confidence: 99%

Social Semantics: The role of conceptual knowledge and cognitive control in a neurobiological model of the social brain

Binney

Ramsey

2020

Neuroscience & Biobehavioral Reviews

119

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“…In a recent study of the role of the right hemisphere in semantic control, there was no significant difference found between RH-damaged patients and normal subjects when they performed a standard battery of semantic tasks including a synonym judgment task (Thompson, Henshall, & Jefferies, 2016). In a recent study of the role of the right hemisphere in semantic control, there was no significant difference found between RH-damaged patients and normal subjects when they performed a standard battery of semantic tasks including a synonym judgment task (Thompson, Henshall, & Jefferies, 2016).…”

Section: Introductionmentioning

confidence: 94%

“…Notably however, the activation pattern in RH stroke patients who are attempting to understand a proverb has not been identified, nor whether this differs from the normal population. In a recent study of the role of the right hemisphere in semantic control, there was no significant difference found between RH-damaged patients and normal subjects when they performed a standard battery of semantic tasks including a synonym judgment task (Thompson, Henshall, & Jefferies, 2016). This suggests that either the RH is not strongly associated with semantic tasks or that a compensatory mechanism exists in another part of the brain.…”

Section: Introductionmentioning

confidence: 94%

Perilesional and homotopic area activation during proverb comprehension after stroke

Kim

Shim

et al. 2018

Brain and Behavior

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IntroductionThe mechanism of functional recovery in right hemisphere (RH) stroke patients when attempting to comprehend a proverb has not been identified. We previously reported that there is bilateral hemisphere involvement during proverb comprehension in the normal population. However, the underlying mechanisms of proverb comprehension following a right middle cerebral artery (MCA) infarction have not yet been fully elucidated.MethodsWe here compared the brain regions activated by literal sentences and by opaque or transparent proverbs in right MCA infarction patients using functional magnetic resonance imaging (fMRI). Experimental stimuli included 18 opaque proverbs, 18 transparent proverbs, and 18 literal sentences that were presented pseudorandomly in 1 of 3 predesigned sequences.ResultsFifteen normal adults and 17 right MCA infarction patients participated in this study. The areas of the brain in the stroke patients involved in understanding a proverb compared with a literal sentence included the right middle frontal gyrus (MFG) and frontal pole, right anterior cingulate gyrus/paracingulate gyrus and left inferior frontal gyrus (IFG), middle temporal gyrus (MTG), precuneus, and supramarginal gyrus (SMG). When the proverbs were presented to these stroke patients in the comprehension tests, the left supramarginal, postcentral gyrus, and right paracingulate gyrus were activated for the opaque proverbs compared to the transparent proverbs.ConclusionsThese findings suggest that the functional recovery of language in stroke patients can be explained by perilesional activation, which is thought to arise from the regulation of the excitatory and inhibitory neurotransmitter system, and by homotopic area activation which has been characterized by decreased transcallosal inhibition and astrocyte involvement.

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“…culdade relativamente à ! guração (Cardillo et al, 2016;Thompson et al, 2016;Schmidt e Seger, 2009;Bookheimer, 2002).…”

Section: Introductionunclassified

Anatomia da Linguagem: Podemos Compreender Jogos de Linguagem a Partir de Redes Corticais?

Hipólito

2017

Kairos. Journal of Philosophy &Amp; Science

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Há metáforas que são mais reais do que a gente que anda na rua. Bernardo SoaresResumo Há actualmente muito interesse na investigação dos substractos neuronais do processamento da metáfora. Tem vindo a ser sugerido que o hemisfério direito detém um papel essencial na compreensão da linguagem ! gurativa (não literal) e, em particular, nas metáforas. A linguagem ! gurativa integra-se na Pragmática, disciplina da linguística que se dedica ao estudo do uso da língua, por oposição ao estudo do sistema da língua. Continua, no entanto, aberto o debate sobre os aspetos especí! cos em que opera a semântica e aqueles em que domina a pragmática. Podem os estudos sobre correlatos neuronais clari! car questões sobre a representação semântica/pragmática? Analisaremos os avanços neurocientí! cos sobre a linguagem implícita, para tentarmos perceber, na secção 2, as técnicas cientí! cas disponíveis e mais adequadas à fenomenologia do acto de compreender uma mensagem implícita, ! gurada ou implicada num determinado jogo de linguagem. Para tal, começaremos por rever os estudos em ! loso! a da linguagem, e acomodar o desenvolvimento da investigação em pragmática subjacente à metáfora, em particular nas Investigações Filosóficas de Wittgenstein. Finalmente, discuto a possibilidade de as capacidades interpretativas poderem ser socioculturalmente fundamentadas. Espera-se que esta metodologia de análise contribua para o esclarecimento do problema da fenomenologia da pragmática intersubjectiva, e para os seus futuros paradigmas experimentais.Palavras-chave pragmática; linguagem ! gurativa; metáfora, jogos de linguagem, correlatos neurais; neuroimagem.Abstract There is today much interest in research of neuronal substrata in metaphor processing. It has been suggested that the right hemisphere yields a key role in the comprehension of ! gurative language (non-literal) and, particularly, in metaphors. Figurative language is included in pragmatics, a branch of linguistics that researches the use of language, in opposition to the study of the system of language. There lingers, though, an open debate in respect to the identi! cation of the speci! c aspects concerning semantics, as opposed to those dominated by pragmatics. Can studies from neuronal correlates clarify questions that relate to semantics/pragmatics representation? I shall analyze neuroscienti! c developments about implicit language to attempt to understand, in section 2, scienti! c techniques available and more suitable to the phenomenology of the act of understanding an implicit, ! gurative or implicated message in a certain language game. To do so, I shall start by reviewing the studies in philosophy of language, and accommodate the development of the research in pragmatics underlying metaphor, particularly, in Philosophical Investigations by Wittgenstein. Finally, I discuss the possibility of interpretative capabilities being socioculturally grounded. I expect this methodological analysis to contribute to the enlightenment of the problem of phenomenology of intersubjective pragm...

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The role of the right hemisphere in semantic control: A case-series comparison of right and left hemisphere stroke

Cited by 26 publications

References 124 publications

Social Semantics: The role of conceptual knowledge and cognitive control in a neurobiological model of the social brain

Social Semantics: The role of conceptual knowledge and cognitive control in a neurobiological model of the social brain

Perilesional and homotopic area activation during proverb comprehension after stroke

Anatomia da Linguagem: Podemos Compreender Jogos de Linguagem a Partir de Redes Corticais?

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