The role of the right temporo–parietal junction in social decision‐making

Bitsch, Florian; Berger, Philipp; Nagels, Arne; Falkenberg, Irina; Straube, Benjamin

doi:10.1002/hbm.24061

Cited by 39 publications

(41 citation statements)

References 92 publications

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“…The TPJ is involved in multiple cognitive functions (Alkire, Levitas, Warnell, & Redcay, ; Baumgartner, Dahinden, Gianotti, & Knoch, ; Donaldson et al, ; Fujino, Yamasaki, et al, ; Mars et al, ; Soutschek et al, ). In particular, the right TPJ plays a key role in social cognition, such as perspective taking (Krall et al, ; Schurz, Tholen, Perner, Mars, & Sallet, ; Tei et al, ), moral decision‐making (Bitsch, Berger, Nagels, Falkenberg, & Straube, ; Chen, Decety, Huang, Chen, & Cheng, ; Tei et al, , ; Young, Camprodon, Hauser, Pascual‐Leone, & Saxe, ), and strategic social behavior (Hampton, Bossaerts, & O'Doherty, ; Hill et al, ). Significantly, previous fMRI studies have shown that the right TPJ plays a vital role in differentiating between in‐group and out‐group members in judgments and behavior (Baumgartner et al, ; Falk et al, ; Wu et al, ).…”

Section: Discussionmentioning

confidence: 99%

Role of the right temporoparietal junction in intergroup bias in trust decisions

Fujino

Tei

Itahashi

et al. 2019

Human Brain Mapping

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Intergroup bias, which is the tendency to behave more positively toward an in‐group member than toward an out‐group member, is pervasive in real life. In particular, intergroup bias in trust decisions substantially influences multiple areas of life and thus better understanding of this tendency can provide significant insights into human social behavior. Although previous functional magnetic resonance imaging studies showed the involvement of the right temporoparietal junction (TPJ) in intergroup trust bias, a causal relationship between the two has rarely been explored. By combining repetitive transcranial magnetic stimulation and a newly developed trust game task, we investigated the causal role of the right TPJ in intergroup bias in trust decisions. In the trust game task, the counterpart's group membership (in‐group or out‐group) and reciprocity were manipulated. We applied either neuronavigated inhibitory continuous theta burst stimulation (cTBS) or sham stimulation over the right TPJ before performing the trust game task in healthy volunteers. After the sham stimulation, the participants' degrees of investments with in‐group members were significantly higher than those with out‐group members. However, after cTBS to the right TPJ, this difference was not observed. The current results extend previous findings by showing that the causal roles of the right TPJ can be observed in intergroup bias in trust decisions. Our findings add to our understanding of the mechanisms of human social behavior.

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Section: Discussionmentioning

confidence: 99%

Role of the right temporoparietal junction in intergroup bias in trust decisions

Fujino

Tei

Itahashi

et al. 2019

Human Brain Mapping

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“…However, since the amygdala is an important brain region for emotion recognition [24,62] and has been shown to be involved in salience processing [28], further studies are needed to investigate the specific role of the amygdala in social decision making. In addition, to investigate the importance of different brain regions in social decision making more comprehensively, the presented social JTC-task might be analyzed with regard to the right temporoparietal junction and particularly its functional connectivity with the left hippocampus, which recently has been shown to be important for social decision making and social learning in the context of an iterated prisoner's dilemma game [63].…”

Section: Discussionmentioning

confidence: 99%

Nucleus accumbens activation is linked to salience in social decision making

Schmidt

Fenske

Koehler

et al. 2018

Eur Arch Psychiatry Clin Neurosci

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Aberrant salience may explain hasty decision making and psychotic symptoms in schizophrenia. In healthy individuals, final decisions in probabilistic reasoning tasks are related to Nucleus accumbens (Nacc) activation. However, research investigating the Nacc in social decision making is missing. Our study aimed at investigating the role of the Nacc for social decision making and its link to (aberrant) salience attribution. 47 healthy individuals completed a novel social jumping-to-conclusion (JTC) fMRI-paradigm, showing morphed faces simultaneously expressing fear and happiness. Participants decided on the 'current' emotion after each picture, and on the 'general' emotion of series of faces. Nacc activation was stronger during final decisions than in previous trials without a decision, particularly in fear rather than happiness series. A JTC-bias was associated with higher Nacc activation for last fearful, but not last happy faces. Apparently, mechanisms underlying probabilistic reasoning are also relevant for social decision making. The pattern of Nacc activation suggests salience, not reward, drives the final decision. Based on these findings, we hypothesize that aberrant salience might also explain social-cognitive deficits in schizophrenia.

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“…During creative cognition, neuroimaging findings reveal activity patterns in a widespread neural network involving brain regions related with cognitive control mechanisms such as the superior frontal gyrus (Hu et al, 2016), the inferior frontal gyrus (IFG, Beaty et al, 2014;Flaherty, 2005), the dorsolateral prefrontal cortex (dlPFC, Beaty et al, 2015;Flaherty, 2005) and brain regions associated with default mode processes such as the bilateral inferior parietal lobule (IPL), the posterior cingulate cortex (PCC), the medial prefrontal cortex (mPFC) and areas in the medial temporal lobe (MTL) such as the amygdala and the hippocampus, which are assumed to be critical for spontaneous and broadened thinking Bitsch et al, 2018b;Buckner et al, 2008). Humor production abilities have been found to have much in common with other forms of verbal creativity (Nusbaum et al, 2017;Perchtold-Stefan et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Antagonism Between Brain Regions Relevant for Cognitive Control and Emotional Memory Facilitates the Generation of Humorous Ideas

Bitsch

Berger

Fink

et al. 2020

Preprint

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The ability to generate humor gives rise to positive emotions and thus facilitate the successful resolution of adversity. Although there is consensus that inhibitory processes might be related to broaden the way of thinking, the neural underpinnings of these mechanisms are largely unknown. Here, we use functional Magnetic Resonance Imaging, a humorous alternative uses task and a stroop task, to investigate the brain mechanisms underlying the emergence of humorous ideas in 24 subjects. Neuroimaging results indicate that greater cognitive control abilities are associated with increased activation in the amygdala, the hippocampus and the superior and medial frontal gyrus during the generation of humorous ideas. Examining the neural mechanisms more closely shows that the downregulation of frontal brain regions is associated with an upregulation in the amygdala, which is concurrently linked with an increased number of humorous ideas and enhanced amygdala responses during the task. Our data therefore suggests that a neural antagonism previously related to the emergence and regulation of negative affective responses, is linked with the generation of emotionally positive ideas and may represent an important neural pathway supporting mental health.

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The role of the right temporo–parietal junction in social decision‐making

Cited by 39 publications

References 92 publications

Role of the right temporoparietal junction in intergroup bias in trust decisions

Role of the right temporoparietal junction in intergroup bias in trust decisions

Nucleus accumbens activation is linked to salience in social decision making

Antagonism Between Brain Regions Relevant for Cognitive Control and Emotional Memory Facilitates the Generation of Humorous Ideas

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