The role of the rat submandibular gland in the excretion of bis (tributyltin) oxide: Electron microscopy, X-ray microanalysis and atomic absorption analysis

Cytopathological effects on organelles of penis epithelium cells were investigated in prosobranchs that had been exposed for two weeks to three months to high TBT-concentrations in artificial seawater. TBT exposure damaged cell organelles, such as mitochondria, Golgi dictyosomes, endoplasmatic reticulum, and injured the cell membranes. In addition, atypical intercellular spaces were observed between the cells of the epithelial layer. Further cell alterations included the increase of residual bodies within the cells as well as structural changes of the basal lamina. The ultrastrucrural changes were compared with cell alterations of specimens which had been collected in a polluted environment on the coast of Brittany (France).

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Cellular effects of tributyltin (TBT) on the penis epithelium cells of prosobranchs (Hinia reticulata andOcinebrina aciculata)

Brick

Deutsch

Fioroni

1996

Helgolander Meeresunters

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Toxic Effects of Bis (Tributyltin) Oxide on the Synthesis and Secretion of Zymogen Granules in the Rat Exocrine Pancreas.

Hara

Yoshizuka

Fujimoto

1994

Archives of Histology and Cytology

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Morphological Alterations of Submandibular Glands Caused by Cisplatin in the Rat

Kitashima

2005

Kurume Med. J.

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Cisplatin is a platinum-containing antineoplastic agent, widely used in the treatment of various malignant neoplasms including head and neck cancer. In this study we examined ultrastructural changes of rat submandibular glands (SMGs) after cisplatin treatment. Male Wistar rats aged 8 weeks were used in the experiments. Cisplatin was injected intraperitoneally into the rats (5 mg/kg/day) for three consecutive days. After 1, 3, 5, and 7 days, the SMGs were removed and observed under an electron microscope. The terminal portion of the SMG is seromucosal. Acinar cells contained a parallel array of rough-surfaced endoplasmic reticulum in the basal cytoplasm, and the apical cytoplasm was filled with homogeneous secretory granules. Vacuolation of cells was observed on the first day after cisplatin treatment. On the third and fifth days, the rough-surfaced endoplasmic reticulum showed an irregular arrangement. Mitochondrial swelling, and the presence of autophagolysosomes was also confirmed. On the seventh day, the damage to organelles began to decrease and the SMG exhibited a tendency towards improvement.

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The role of the rat submandibular gland in the excretion of bis (tributyltin) oxide: Electron microscopy, X-ray microanalysis and atomic absorption analysis

Cited by 4 publications

References 10 publications

Cellular effects of tributyltin (TBT) on the penis epithelium cells of prosobranchs (Hinia reticulata andOcinebrina aciculata)

Cellular effects of tributyltin (TBT) on the penis epithelium cells of prosobranchs (Hinia reticulata andOcinebrina aciculata)

Toxic Effects of Bis (Tributyltin) Oxide on the Synthesis and Secretion of Zymogen Granules in the Rat Exocrine Pancreas.

Morphological Alterations of Submandibular Glands Caused by Cisplatin in the Rat

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