The role of the pineal gland in the photoperiodic control of reproduction in different hamster species

Pévet, Paul

doi:10.1051/rnd:19880310

Cited by 129 publications

(65 citation statements)

References 54 publications

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“…The best example of such photoperiod-dependent physiological functions is the activation/inactivation of the reproductive axis, a phenomenon in which the pineal and its MEL rhythm are essential. Numerous studies have now demonstrated that the pineal gland is a neuroendocrine transducer receiving photoperiodic information from the retina and circadian SCN oscillator, and transmitting this to the reproductive system via a particular dynamic pattern of MEL secretion (see Hoffmann, 1979;Reiter, 1980;Goldman and Darrow, 1983;Bittman, 1984;Tamarkin et al, 1985;Pévet, 1988;Goldman, 2001 for reviews). However, several fundamental questions remain before the role of MEL in the regulation of seasonal function is elucidated: 1) where is the photoperiodic information encoded before its translation into the MEL rhythm?…”

Section: A Regulation Of Seasonal Rhythmsmentioning

confidence: 99%

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

2003

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Section: A Regulation Of Seasonal Rhythmsmentioning

confidence: 99%

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

2003

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“…In mammals, a dedicated photoneuroendocrine system (fig. 1) transduces the ambient photoperiod to control the production of the hormone melatonin [3,4,5,6,7], which in turn coordinates physiological functions, such as reproductive activity, to the photoperiod [3,4,5]. …”

Section: Seasonal Control Of Reproduction: From Photonic Energy To Spmentioning

confidence: 99%

Melatonin Controls Seasonal Breeding by a Network of Hypothalamic Targets

et al. 2009

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In seasonal species, the photoperiod (i.e. day length) tightly regulates reproduction to ensure that birth occurs at the most favourable time of year. In mammals, a distinct photoneuroendocrine circuit controls this process via the pineal hormone melatonin. This hormone is responsible for the seasonal timing of reproduction, but the anatomical substrates and the cellular mechanisms through which melatonin modulates seasonal functions remain imprecise. Recently, several genes have been identified as being regulated by the photoperiod in the brain of seasonal mammals. These genes are thought to play active roles in the regulation of seasonal biology, notably for the adjustment of reproduction and body weight. Here, we briefly review findings associated with the control of seasonal breeding and describe recent data ascribing photoperiodic roles to type 2 and type 3 deiodinases, to the Kiss1/GPR54 system and to the RFamide-related peptides.Interestingly, these systems involve different hypothalamic nuclei, suggesting that several brain loci may be crucial for melatonin to regulate reproduction, and thus represent key starting points to identify the long-sought-after mode and site(s) of action of melatonin. Such findings raise great hopes for the future and could herald a new era of research in the field of seasonal biology.

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“…Seasonal reproduction is a complex biological phenomenon, which relies on both internal and external environments. Photoperiod is a typical seasonal variation that regulates reproduction in seasonal breeders, and most seasonal breeders modulate reproductive activity by responding to the photoperiod (Pévet, 1988;Bartke and Steger, 1992;Goldman, 2001;Prendergast, 2005). Photoperiodic information can be transmitted to the reproductive system by melatonin (Simonneaux et al, 2009), which is a pineal hormone that is secreted at levels which are proportional to the night length.…”

Section: Introductionmentioning

confidence: 99%

Photoperiod regulates the differential expression of KiSS-1 and GPR54 in various tissues and sexes of striped hamster

Xue

Zhang

et al. 2015

Genet. Mol. Res.

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ABSTRACT. In order to investigate how photoperiod affects the expression of KiSS-1/G-protein-coupled receptor 54 (GPR54), the hypothalamus, the ovaries and testicles of the striped hamster were studied following photoperiod treatment and melatonin injection. We found that the melatonin concentration in the blood of the striped hamster was consistent with the treated photoperiods and that the photoperiod had significant effects on KiSS-1 expression, but the effect of photoperiod on GPR54 expression differed among tissues and sexes. The relative expression of KiSS-1 in the gonads of the male and female striped hamster was significantly higher than that in the hypothalamus, while the difference in GPR54 between the gonads and hypothalamus was inconsistent between the male and female striped hamster. In the striped hamster injected with melatonin, the expression level of KiSS-1 in the gonads and hypothalamus of the male and female striped hamster was significantly decreased; the expression level of GnRH in the gonads was also significantly decreased; the expression of GPR54 in the hypothalamus was increased. In the hypothalamus, a significant positive correlation existed between KiSS-1 and GnRH expression, while a negative correlation was observed between 13895 Photoperiod regulates expression of KiSS-1 and GPR54 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 13894-13905 (2015) GPR54 and GnRH expression. These results suggest that the photoperiodmelatonin-KiSS-1-GnRH pathway plays an important role in the seasonal reproduction mechanism of the striped hamster. Additionally, photoperiod or melatonin may not be a direct regulatory factor of GPR54 expression.

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The role of the pineal gland in the photoperiodic control of reproduction in different hamster species

Abstract: Introduction.

Cited by 129 publications

References 54 publications

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

Melatonin Controls Seasonal Breeding by a Network of Hypothalamic Targets

Photoperiod regulates the differential expression of KiSS-1 and GPR54 in various tissues and sexes of striped hamster

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