Based on the survey data from questionnaire of Quality Management of Pharmaceutical Production Enterprises in Anhui Province, this research examines the relationship between the change frequency of production director and GMP inspection results of pharmaceutical manufacturers by adopting OLS model and Logit model. We find that director of manufacturing management plays a direct role in enterprise production management as senior administrator. If director of manufacturing management changes more times, the enterprise's drug production management will lose persistent stability. As a result, the quality of drug production is affected. Without ability to produce high-quality drugs, the GMP inspection results of pharmaceutical enterprises are poor. Thus, this paper suggests that in daily drug quality supervision, enterprises that frequently change director of manufacturing management should be paid more attention to, and we should increase the frequency of examination, so as to reasonably allocate regulatory resources and carry out targeted supervision.