2011
DOI: 10.1371/journal.ppat.1002212
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The Role of the P2X7 Receptor in Infectious Diseases

Abstract: ATP is an extracellular signal for the immune system, particularly during an inflammatory response. It is sensed by the P2X7 receptor, the expression of which is upregulated by pro-inflammatory cytokines. Activation of the P2X7 receptor opens a cation-specific channel that alters the ionic environment of the cell, activating several pathways, including (i) the inflammasome, leading to production of IL-1β and IL-18; (ii) the stress-activated protein kinase pathway, resulting in apoptosis; (iii) the mitogen-acti… Show more

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Cited by 128 publications
(134 citation statements)
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References 88 publications
(107 reference statements)
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“…The NudP* defects in blood and organs appeared only at the later time point of 48 h, suggesting that NudP is dispensable at early time points of infection. Because NudP acts on extracellular nucleotides, it highlights the role of these extracellular nucleotides in modulating host responses to bacterial infections (2,8,14,18,51).…”
Section: Discussionmentioning
confidence: 99%
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“…The NudP* defects in blood and organs appeared only at the later time point of 48 h, suggesting that NudP is dispensable at early time points of infection. Because NudP acts on extracellular nucleotides, it highlights the role of these extracellular nucleotides in modulating host responses to bacterial infections (2,8,14,18,51).…”
Section: Discussionmentioning
confidence: 99%
“…The function and the subversion of the eATP receptors, the P2X family, during infections are mainly documented for intracellular microbial pathogens (14,51). In contrast, few studies have address the function of eATP/eAdo receptors during infections by extracellular pathogens and hence the biological consequences of modulating the eATP/eADP ratio (14,51).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Associations between susceptibility or resistance to parasites and bacteria and loss-or gain-of-function polymorphisms in the P2X7 receptor indicate that it is important in infectious disease [121]. ATP activation of the NLRP3 inflammasome protects mice against bacterial infection [122].…”
Section: Pathology and Inflammationmentioning
confidence: 99%
“…Moreover, P2X7 signaling can cause the formation of large nonselective membrane pores and induce dynamic membrane blebbing [12,13]. This receptor plays important roles in chronic pain [14,15], apoptosis [16][17][18], bone remodeling [19][20][21], immune responses [22][23][24][25] and the function of exocrine and endocrine organs [26,27].…”
Section: Introductionmentioning
confidence: 99%