The role of the nitric oxide generation system in neuroleptic-induced Parkinsonism

Dolgo-Saburov, V. B.; Dagaev, S. G.; Kubarskaya, L. G.; Solovjeva, N. E.

doi:10.1134/s0012496612030052

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“…Despite the fact that damage to cellular structures is observed during oxidative stress, its components act as second messengers in the formation of regulatory functions. One of the free radicals of oxidative stress that regulates various cellular signaling pathways is nitric oxide (NO) [ 78 ]. When NO synthase is inhibited, enzyme activity is reduced by 80%, leading to the formation of primary and secondary products of lipid peroxidation (conjugated dienes (CD) and trienes (CT), malondialdehyde (MDA) and Schiff bases (SB)).…”

Section: Introductionmentioning

confidence: 99%

Pathophysiological Mechanisms of Antipsychotic-Induced Parkinsonism

et al. 2022

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Among neurological adverse reactions in patients with schizophrenia treated with antipsychotics (APs), drug-induced parkinsonism (DIP) is the most common motility disorder caused by drugs affecting dopamine receptors. One of the causes of DIP is the disruption of neurotransmitter interactions that regulate the signaling pathways of the dopaminergic, cholinergic, GABAergic, adenosinergic, endocannabinoid, and other neurotransmitter systems. Presently, the development mechanisms remain poorly understood despite the presence of the considered theories of DIP pathogenesis.

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Section: Introductionmentioning

confidence: 99%