The role of the neuroma in autotomy following sciatic nerve section in rats

Barberá, José; Garcia, Gaspar; Lopez-Orta, Angel; Gil-Salú, J.L.

doi:10.1016/0304-3959(88)90299-0

Cited by 13 publications

(3 citation statements)

References 17 publications

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“…The diagnosis and treatment of traumatic transection in the peripheral nervous system is one of the greatest challenges in neurosurgery. In such cases, a variety of methods was used to reduce neuroma formation characterized by accumulation of connective tissue which has a negative effect on nerve regeneration at the transection site [1, 2, 4, 7, 27, 28]. The scar neuroma characterized by an excessive collagen formation has been suggested to establish a mechanical barrier to axonal regeneration and result in neural conduction blockade [1, 3–7, 29].…”

Section: Discussionmentioning

confidence: 99%

“…Macroscopically, a giant proximal neuroma formation with surrounding excessive adhesions was present in Px rats, whereas there was a small neuroma with slight adhesions in animals given melatonin treatment after Px. Also, there was a reduced automutilation after melatonin, although the etiology of autotomy in rats remains uncertain [28, 45]. Histologically, diffuse proliferation of fibroblasts in the neuromas in Px rats was observed, but regenerating axons were widely seen at the cross‐sections of the proximal nerve ends after melatonin administration.…”

Section: Discussionmentioning

confidence: 99%

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Pinealectomy exaggerates and melatonin treatment suppresses neuroma formation of transected sciatic nerve in rats: gross morphological, histological and stereological analysis

Turğut

Uyanıkgil

Baka

et al. 2004

Journal of Pineal Research

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At present, an intensive effort for prevention of neuroma formation following peripheral nerve section continues. It has been recently suggested that surgical pinealectomy (Px) induces elevation of the collagen content in the granulation tissue of a wound, while melatonin application after Px suppresses elevation of the collagen accumulation in the tissue. The aim of the present study was to assess whether melatonin had the ability to suppress collagen production and neuroma formation following peripheral nerve transection. A total of 40 male rats (four groups of 10) were left intact (intact controls) or sham operated (sham group), were Px, or were Px and given melatonin (Px + melatonin group). All animals underwent a surgical intervention consisting of right sciatic nerve neurectomy. After 4 wk, the animals were killed following intracardiac perfusion. Gross morphology of neuroma formation in the proximal nerve segment was examined and proximal neuroma evaluated. Macroscopic and microscopic findings revealed that Px caused a proliferation of connective tissue and large neuroma formation at the proximal ends of transected nerves. Stereological analysis showed that there was a statistically significant reduction in connective tissue content of the same region in Px animals treated with melatonin (P < 0.005). The results achieved in a rodent model of sciatic nerve neuroma formation showed that there was a positive correlation between macroscopic and microscopic observations, and that melatonin enhanced axonal regeneration presumably due to its inhibitory effect on neuroma formation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pinealectomy exaggerates and melatonin treatment suppresses neuroma formation of transected sciatic nerve in rats: gross morphological, histological and stereological analysis

Turğut

Uyanıkgil

Baka

et al. 2004

Journal of Pineal Research

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“…Sunderland et al, based on the neuroma's location, gross morphology, and damage pattern of nerve microstructure, systematically categorized neuromas into three groups [20,21]: Neuroma-in-continuity (Figure 1(c-1)) constitute 60-70% of the total number of neuromas. The distinctive structural feature of continuous neuromas is the presence of macroscopic expansion areas on intact nerve fibers.…”

Section: Peripheral Nerve Injuries and Neuromamentioning

confidence: 99%

Strategies for Treating Traumatic Neuromas with Tissue-Engineered Materials

Wan,

Li,

Qin

et al. 2024

Biomolecules

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Neuroma, a pathological response to peripheral nerve injury, refers to the abnormal growth of nerve tissue characterized by disorganized axonal proliferation. Commonly occurring after nerve injuries, surgeries, or amputations, this condition leads to the formation of painful nodular structures. Traditional treatment options include surgical excision and pharmacological management, aiming to alleviate symptoms. However, these approaches often offer temporary relief without addressing the underlying regenerative challenges, necessitating the exploration of advanced strategies such as tissue-engineered materials for more comprehensive and effective solutions. In this study, we discussed the etiology, molecular mechanisms, and histological morphology of traumatic neuromas after peripheral nerve injury. Subsequently, we summarized and analyzed current nonsurgical and surgical treatment options, along with their advantages and disadvantages. Additionally, we emphasized recent advancements in treating traumatic neuromas with tissue-engineered material strategies. By integrating biomaterials, growth factors, cell-based approaches, and electrical stimulation, tissue engineering offers a comprehensive solution surpassing mere symptomatic relief, striving for the structural and functional restoration of damaged nerves. In conclusion, the utilization of tissue-engineered materials has the potential to significantly reduce the risk of neuroma recurrence after surgical treatment.

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Autotomy and the sciatic functional index

et al. 1993

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The rat sciatic nerve serves as a good model of nerve regeneration and, as such, is often used in investigations of nerve repair. After transection of the sciatic nerve, rodents frequently scratch and bite their anesthetic foot, resulting in amputation of one or more toes. This is termed autotomy or autophagy. When these rats are part of a study using the sciatic functional index (SFI), autotomy results in unusable data, since necessary foot landmarks have been removed. It would be helpful, therefore, to be familiar with the phenomenon of autotomy and to know which rats are least likely to mutilate themselves. In our experiment involving 64 rats in which the sciatic nerve was transected and repaired, we found that female Sprague-Dawley rats were significantly less likely to perform autotomy than males (33% vs. 65%, P = .04). In addition, we noted that two-thirds of the autotomies that occurred did so by postoperative week 4 and that tabasco sauce did not decrease this activity. We present our experience and a survey of the literature on autotomy and the SFI.

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The role of the neuroma in autotomy following sciatic nerve section in rats

Cited by 13 publications

References 17 publications

Pinealectomy exaggerates and melatonin treatment suppresses neuroma formation of transected sciatic nerve in rats: gross morphological, histological and stereological analysis

Pinealectomy exaggerates and melatonin treatment suppresses neuroma formation of transected sciatic nerve in rats: gross morphological, histological and stereological analysis

Strategies for Treating Traumatic Neuromas with Tissue-Engineered Materials

Autotomy and the sciatic functional index

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