The Role of the Nervous System in Muscle Atrophy

Bhanushali, Minal; Conwit, Robin; Metter, Jeffrey; Ferrucci, Luigi

doi:10.1002/9781118338032.ch4

Cited by 4 publications

(3 citation statements)

References 127 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A theoretical model arising out of a review of cognitive ageing, motor learning and motor skills59 predicts that ageing impairs cognitive functions before affecting the motor systems and that at older ages the connection between cognition and action becomes stronger, as suggested by our findings. To what extent our findings reflect a direct pathway between brain ageing and muscle strength,60 or shared mechanisms relating, for example, to haemostatic dysregulation or inflammatory processes,24 61 is yet to be clarified.…”

Section: Discussionmentioning

confidence: 92%

Developmental factors associated with decline in grip strength from midlife to old age: a British birth cohort study

et al. 2019

View full text Add to dashboard Cite

ObjectivesTo test whether developmental factors are associated with grip strength trajectories between 53 and 69 years, and operate independently or on the same pathway/s as adult factors.DesignBritish birth cohort study.SettingEngland, Scotland and Wales.Participants3058 men and women.Main outcome measuresGrip strength (kg) at ages 53, 60–64 and 69 were analysed using multilevel models to estimate associations with developmental factors (birth weight, growth parameters, motor and cognitive development) and father’s social class, and investigate adult factors that could explain observed associations, testing for age and sex interactions.ResultsIn men, heavier birth weight, beginning to walk ‘on time’, later puberty and greater weight 0–26 years and in women, heavier birth weight and earlier age at first standing were independently associated with stronger grip but not with its decline. The slower decline in grip strength (by 0.07 kg/year, 95% CI 0.02 to 0.11 per 1 SD, p=0.003) in men of higher cognitive ability was attenuated by adjusting for adult verbal memory.ConclusionsPatterns of growth and motor development have persisting associations with grip strength between midlife and old age. The strengthening associations with cognition suggest that, at older ages, grip strength increasingly reflects neural ageing processes. Interventions across life that promote muscle development or maintain muscle strength should increase the chance of an independent old age.

show abstract

Section: Discussionmentioning

confidence: 92%

Developmental factors associated with decline in grip strength from midlife to old age: a British birth cohort study

et al. 2019

View full text Add to dashboard Cite

show abstract

“…[ 9 10 11 ] Therefore, it is important to explore deeper into the mechanism or etiology of sarcopenia, other than muscle itself, which in turn will provide further insight into the development of more effective therapy. [ 12 ]…”

Section: Introductionmentioning

confidence: 99%

Sarcopenia: Neurological Point of View

Kwon

Yoon

2017

J Bone Metab

View full text Add to dashboard Cite

Sarcopenia is an age-related geriatric syndrome which is characterized by the gradual loss of muscle mass, muscle strength, and muscle quality. There are a lot of neurologic insults on sarcopenia at various levels from the brain to the neuromuscular junctions (NMJs) to generate a volitional task. Dopaminergic downregulation, inadequate motor programming and motor coordination impairment lead to decline of supraspinal drive. Motor unit reorganization and inflammatory changes in motor neuron decrease conduction velocity and amplitude of compound muscle action potential. Furthermore, NMJ remodeling and age related neurophysiological alterations may contribute to neuromuscular impairment. Sarcopenia is an age-associated, lifelong process which links to multiple etiological factors. Although not all the causes are completely understood, we suggest that compromised nervous system function may be one of the important contributors to the sarcopenia.

show abstract

“…A theoretical model arising out of a review of cognitive ageing, motor learning and motor skills (57) predicts that ageing impairs cognitive functions before affecting the motor systems and that at older ages the connection between cognition and action becomes stronger, as suggested by our findings. To what extent our findings reflect a direct pathway between brain ageing and muscle strength, (58) or shared mechanisms relating, for example, to haemostatic dysregulation or inflammatory processes, (24,59) is yet to be clarified.…”

Section: Discussionmentioning

confidence: 94%

Developmental factors associated with decline in grip strength from midlife to old age: a British birth cohort study

Kuh

Hardy

Blodgett

et al. 2018

Preprint

View full text Add to dashboard Cite

Maintenance of muscle strength is important for healthy ageing, protecting against chronic disease and enabling independent living. We tested whether developmental factors were associated with grip strength trajectories between 53 and 69 years, and operated independently or on the same pathway/s as adult factors, in 3058 participants from a British birth cohort. Grip strength (kg) at ages 53, 60-64 and 69, was analysed using multilevel models, testing for age and sex interactions, to estimate associations with developmental factors (birthweight, growth parameters, motor and cognitive development) and childhood socioeconomic position (SEP) and investigate potential adult mediators. Heavier birthweight, beginning to walk on time, later puberty and greater weight 0-26 years in men, and earlier age at first standing in women, were associated with stronger grip but not with its decline; these associations were independent of adult factors. The slower decline in grip strength (by 0.068kg/year, 95% confidence interval (CI) 0.024,0.11 per 1SD, p=.003) in men with higher childhood cognition was attenuated by adult verbal memory which became increasingly positively associated with grip strength at older ages. Thus grip strength may increasingly reflect neural ageing processes. Targeting developmental factors to promote muscle development should increase the chance of independence in old age.

show abstract

The Role of the Nervous System in Muscle Atrophy

Cited by 4 publications

References 127 publications

Developmental factors associated with decline in grip strength from midlife to old age: a British birth cohort study

Developmental factors associated with decline in grip strength from midlife to old age: a British birth cohort study

Sarcopenia: Neurological Point of View

Developmental factors associated with decline in grip strength from midlife to old age: a British birth cohort study

Contact Info

Product

Resources

About