The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria

Wellington, Elizabeth M. H.; Boxall, Alistair; Cross, Paul; Feil, Edward J.; Gaze, William H.; Hawkey, Peter M.; Johnson-Rollings, Ashley S.; Jones, Davey L.; Lee, Nick; Otten, Wilfred; Thomas, Christopher M.; Williams, A. Prysor

doi:10.1016/s1473-3099(12)70317-1

Cited by 911 publications

(657 citation statements)

References 114 publications

Supporting

Mentioning

611

Contrasting

Unclassified

Order By: Relevance

“…84,119 Environmental contamination with antibiotics may lead emergence of antibiotic resistance and in turn creates a reservoire for antibiotic resistance genes. 120 On the other hand, it has been consistently shown that those areas where the usage is high, the resistance is widespread both in community and hospital settings. 7,121,122,123 Since the problem of emerging resistance is multifaceted, its prevention and control will require multiple, coordinated interventions by various parties.…”

Section: Acinetobacter Baumanniimentioning

confidence: 99%

Epidemiology of antimicrobial resistance in bloodstream infections

2016

View full text Add to dashboard Cite

Antimicrobial resistance in bacterial pathogens is a worldwide challenge leading high morbidity and mortality in clinical settings. Multidrug resistant patterns in gram-positive and -negative bacteria have resulted in difficult-to-treat or even untreatable infections with conventional antimicrobials. Since the early identification of causative microorganisms and their antimicrobial susceptibility patterns in patients with bacteremia and other serious infections is lacking in many healthcare institutions, broad spectrum antibiotics are liberally and mostly unnecessarily used. Such practice has, in turn, caused dramatic increases in emerging resistance and when coupled with poor practice of infection control, resistant bacteria can easily be disseminated to the other patients and the environment. Thus, availability of updated epidemiological data on antimicrobial resistance in frequently encountered bacterial pathogens will be useful not only for deciding on empirical treatment strategies, but also devising an effective antimicrobial stewardship program in hospitals.

show abstract

Section: Acinetobacter Baumanniimentioning

confidence: 99%

Epidemiology of antimicrobial resistance in bloodstream infections

2016

View full text Add to dashboard Cite

show abstract

“…The resistance genes of these selected bacteria in nature waters could transfer to the terrestrial bacteria and human pathogens by Horizontal Gene Transfer (HGT) in the complicated biosphere (Cabello et al, 2013). As a result of HGT, these new genetic entities may be incorporated into the pangenome of terrestrial bacteria including human pathogens, linking aquatic and terrestrial resistomes and complicating the treatment of human infections (Cabello et al, 2013;Wellington et al, 2013;Sharma et al, 2016). In addition, aquatic products for human consumption can become contaminated with antibiotics residues.…”

Section: Ecological Hazard Assessmentmentioning

confidence: 99%

“…Numerous studies have reported the concentrations of antibiotics ranged from several ng per liter to hundreds of μg per liter in various environmental compartments, such as hospital sewage, municipal sewage, surface waters, groundwater, and seawater (Brown et al, 2006;Kümmerer, 2009;Chang et al, 2010;Rodriguez-Mozaz et al, 2015;Yao et al, 2015Yao et al, , 2017Chen et al, 2015a, b;Ngumba et al, 2016;Sui et al, 2017). The antibiotic burden in water can result in direct toxicity to animals (Wollenberger et al, 2000;Wang et al, 2014;Yan et al, 2016) and plants (Migliore et al, 2003;Pan and Chu, 2016), but more importantly, they can induce antibiotic-resistant bacteria or genes, which increase health and ecological hazards through food chains, even at low concentrations (Wellington et al, 2013;Ye et al, 2016;Sharma et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Occurrence and ecological hazard assessment of selected antibiotics in the surface waters in and around Lake Honghu, China

Wang

Yang

et al. 2017

Science of The Total Environment

205

View full text Add to dashboard Cite

“…WWTP-treated effluents are a significant source of antibiotic-resistance gene release into the downstream environment (Lapara et al, 2011;Wellington et al, 2013). Because of their high nutrient content and high bacterial density, WWTPs are hotspots for dissemination of mobile genetic elements (Szczepanowski et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Quantitative and qualitative impact of hospital effluent on dissemination of the integron pool

et al. 2013

View full text Add to dashboard Cite

There is increasing evidence that human activity, and especially the resulting effluent, has a major role in the dissemination of bacterial antibiotic-resistance determinants in the environment. Hospitals are the major antibiotic consumers and thus facilitate the spread of antibiotic resistance. Questions are increasingly being raised about the management of hospital effluents, but their involvement in antibiotic-resistance dissemination has never been assessed. Integrons are a paradigm of genetic transfer between the environmental resistome and both commensal and pathogenic bacteria. In order to assess the impact of hospital activities on antibiotic-resistance dissemination in the environment, we monitored integrons and their gene cassettes in hospital effluents, and their release in the environment. We found that bacterial communities present in a hospital effluent contained a high proportion of integrons. In terms of both their gene cassette diversity and gene cassette arrays, the urban effluent and municipal wastewater treatment plant (WWTP) influent were most similar, whereas the hospital effluent and recirculation sludge exhibited very specific patterns. We found that anthropogenic activities led to the release of abundant integrons and antibiotic-resistance gene cassettes, but we observed no specific impact of hospital activities on the receiving environment. Furthermore, although the WWTP did not reduce the normalized integron copy number, it reduced the diversity of gene cassette arrays contained in the raw wastewater, underlining the effect of the biological treatment on the anthropogenic integron pool arriving at the WWTP.

show abstract

The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria

Cited by 911 publications

References 114 publications

Epidemiology of antimicrobial resistance in bloodstream infections

Epidemiology of antimicrobial resistance in bloodstream infections

Occurrence and ecological hazard assessment of selected antibiotics in the surface waters in and around Lake Honghu, China

Quantitative and qualitative impact of hospital effluent on dissemination of the integron pool

Contact Info

Product

Resources

About