The Role of the Mycobiome in Women’s Health

Abstract

Although the human bacteriome and virome have gained a great deal of attention over the years, the human mycobiome has been far more neglected despite having significant value and implications in human health. In women, mycobiome profiles in breastmilk, vaginal regions, the gut, skin, and the oral cavity can provide insight into women’s health, diseases, and microbiome dysbiosis. Analyses of mycobiome composition under factors, such as health, age, diet, weight, and drug exposure (including antibiotic therapies), help to elucidate the various roles of women’s mycobiome in homeostasis, microbiome interactions (synergistic and antagonistic), and health. This review summarizes the most recent updates to mycobiome knowledge in these critical areas.

Studying the Human Microbiota: Advances in Understanding the Fundamentals, Origin, and Evolution of Biological Timekeeping

“…Over the past 5000 years, S. cerevisiae has accompanied human evolution through food and beverage consumption [294]. It is commonly found in the healthy human microbiota of the oral cavity [295], intestinal tract [296][297][298], skin [299], and vagina [300,301]. The use of S. cerevisiae-based probiotic strains has been shown to give promising therapeutic outcomes in the management of Leśniowski-Crohn disease [302], irritable bowel syndrome, and ulcerative colitis and in the prevention of antibiotic-associated diarrhea, acute diarrhea [303], and bacterial vaginosis [301].…”

Unveiling the mycobiota: The fungal frontier of human health

“…Non-albicans species such as C. krusei , C. parapsilosis , and C. tropicalis are also present. Other commensals include Saccharomycetales , Davidiellaceae , Cladosporium , and Pichia [ 17 ].…”