The role of the Montreal Cognitive Assessment (MoCA) and its memory tasks for detecting mild cognitive impairment

Abstract

To investigate the role of the Montreal Cognitive Assessment (MoCA) (Beijing version) and its memory tasks on detecting different mild cognitive impairment (MCI) subtypes including amnestic MCI (aMCI) and nonamnestic MCI (naMCI) in memory clinics. A total of 121 patients with MCI and 53 healthy controls were included. Fifty-six aMCI-multiple domains (amMCI), 32 aMCI-single domain (asMCI), and 33 naMCI patients were diagnosed according to extensive cognitive tests. All participants were administered by the Mini Mental State Examination (MMSE) and the MoCA. Patients with amMCI performed worse than patients with asMCI, naMCI, and healthy controls on the MMSE and the MoCA (p < 0.001). The area under the curve (AUC) value for the MoCA when comparing the amMCI and control groups was 0.884 (p < 0.001), which was superior to that of the MMSE. The AUC value decreased to 0.687 when applied to the naMCI and control groups (p = 0.007), which was still higher than that of the Rey Auditory Verbal Learning Test (RAVLT) or the Rey-Osterrieth complex figure (ROCF). Delayed free recall or category prompted recall in the MoCA had roles in differentiating asMCI and controls groups with AUC value of 0.717 (p = 0.002) and 0.691 (p = 0.005), respectively. The MoCA is a good screening tool for detecting different types of MCI and is suitable for patients in outpatient clinics.

The Validation of Multifactor Model of Plasma Aβ42 and Total-Tau in Combination With MoCA for Diagnosing Probable Alzheimer Disease

“…To further simplify our model, we tried different combinations, and discovered three variables, Aβ42, Aβ42 × t-tau, and MoCA, are sensitive enough to yield similar prediction accuracy in comparison to a five-variable prediction model (98.2% for the control group, 94.6% for AD group and the overall 96.7%). Moreover, MoCA is a superior screen tool for the identification of mild cognitive impairment compared to MMSE (Li et al, 2018;Pinto et al, 2019). Therefore, the three-variable model is optimal for predicting early stage AD with MoCA as its neuropsychological measurement.…”

Correlations between health-promoting lifestyle and health-related quality of life among elderly people with hypertension in Hengyang, Hunan, China

“…Inclusion criteria were as follows: systolic blood pressure (SBP) ≥ 140 mm Hg and/or diastolic BP ≥ 90 mm Hg, or on antihypertensive medication; age ≥ 60 years; living in Hengyang, Hunan, China; and having no cognitive impairment, based on the Montreal Cognitive Assessment (MoCA). [ 22 ] Exclusion criteria included secondary hypertension; serious end-stage diseases (cancer or serious liver, respiratory, heart, or renal insufficiency); and not verbally agreeing to participate. Prior written and informed consent were obtained from every patient and the study was approved by the Medical Ethics Committee of University of South China (No.…”

Altered Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Without Mild Cognitive Impairment

“…All subjects received a range of neuropsychological tests, which were sensitive and commonly used in T2DM-related studies, including the MoCA (25), auditory verbal learning test (AVLT) (26), trail making test (TMT; including parts A and B) (27), grooved pegboard test (GPT) (28), symbol digit test (SDT) (29), the clock drawing test (CDT) (30), and the digital span test (DST, including forward and backward) (31). The AVLT involved four parts: immediate recall, short-term delayed recall, long-term delayed recall, and recognition.…”