The role of the miR‐17–92 cluster in neurogenesis and angiogenesis in the central nervous system of adults

Abstract

It is well known that neurogenesis is not the only concern for the fully functional recovery after brain or spinal cord injury, as it has been shed light on the critical role of angiogenesis in improving neurological functional recovery. Angiogenesis and neurogenesis coordinately interact with each other in the developing and adult brain, during which they may respond to similar mediators and receptors, in which they share a common posttranscriptional regulator: the miR-17-92 cluster. The miR-17-92 cluster was initially described as an oncogene and was later demonstrated to drive key physiological and pathological responses during development and diseases respectively. It has been reported that the miR-17-92 cluster regulates both neurogenesis and angiogenesis. The miR-17-92 cluster modulates neural progenitor cells proliferation not only during development but also during neurological disorders such as stroke. It has also been shown that the endothelial miR-17-92 cluster regulates angiogenesis during embryonic stage and adulthood. In this review, we have discussed the actions of the miR-17-92 cluster in neuronal and vascular plasticity, and its potential as a novel therapeutic strategy for CNS injury. © 2016 Wiley Periodicals, Inc.

The microRNA-17 ~ 92 Family as a Key Regulator of Neurogenesis and Potential Regenerative Therapeutics of Neurological Disorders

“…The intracellular regulatory network of neurogenesis composed of microRNA (miRNA), transcription factors, epigenetic modification, and other factors, coordinates with extracellular cues to determine the spatial and temporal expression of essential genes that control the proliferation, fate specification, and differentiation of NSCs [6]. miRNAs are a class of highly conserved small noncoding antisense RNAs (20)(21)(22)(23)(24) originally discovered in Coenorhabditis elegans in 1984 [7]. miRNAs are transcribed from endogenous hairpin-shaped transcripts by RNA polymerase II or III [8].…”

Plasma endothelial microvesicles and their carrying miRNA‐155 serve as biomarkers for ischemic stroke

“…Plasma/serum miRNAs have been extensively studied and regarded as potential biomarkers for various diseases (Yang, Cai, et al, 2017). It has been demonstrated that miRNAs packaged in MVs prevents their degradation by RNase and make them stable to indicate the characteristics of the mother cells (Boon & Vickers, 2013 brain tissue was significantly increased, and intracerebroventricular infusion of miR-155 inhibitor could reduce the seizure event (Zhang et al, 2019).…”

A miRNA Signature for Cognitive Deficits and Alcohol Use Disorder in Persons Living with HIV/AIDS

“…We have only considered substance abuse but factors such as co-infections, depression and suicidal behaviors are also relatively common problems in PLWHA (Nanni et al, 2015 ; Tao et al, 2017 ; Vreeman et al, 2017 ) and they could likely have an impact on the miRNA neuro-biomarkers for cognitive impairments. Another consideration is related to the intrinsic nature of miRNAs and their key function in brain development and neuronal fitness (Sun et al, 2013 ; Radhakrishnan and Alwin Prem Anand, 2016 ; Roese-Koerner et al, 2017 ; Yang et al, 2017 ). Similarly to any other gene, miRNAs are subjected to sequence polymorphism such as single nucleotide polymorphisms (SNPs) that could change their function and that were not considered in this study.…”