The Role of the Microbiome in Gut and Joint Inflammation in Psoriatic
                        Arthritis and Spondyloarthritis

Gilis, Elisabeth; Mortier, Céline; Venken, Koen; Debusschere, Karlijn; Vereecke, Lars; Elewaut, Dirk

doi:10.3899/jrheum.180135

Cited by 37 publications

(12 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There have been some studies too which have examined changes in microbiome and onset of PsA 46 which to date have been inconclusive. This is clearly an area for further research focus as microbial-driven populations of IL17-producing innate immune cells have been identified in other tissues 47 and a recent study very nicely demonstrated the considerable influence of the gut microbiota-together and over time-on systemic immune cell dynamics.…”

mentioning

confidence: 99%

Psoriatic arthritis

FitzGerald

Ogdie

Chandran

et al. 2021

Nat Rev Dis Primers

163

View full text Add to dashboard Cite

General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Download date: 05. Dec. 2022 1 nature REVIEWS Nature Reviews referee guidelines Primer articles Nature Reviews publishes timely, authoritative articles that are of broad interest and exceptional quality. Thank you for taking the time to help us to ensure that our articles meet these high standards.Primer articles in Nature Reviews provide an overview of a disease or disorder. Primers are intended to provide an authoritative, global perspective for the benefit of biomedical scientists, putting current clinical and translational challenges into context. These overview articles are meant to be introductory and cover all aspects from epidemiology to disease mechanisms, diagnosis and treatment.Please submit your report in narrative form and provide detailed justifications for all statements. Confidential comments to the editor are welcome, but it is helpful if the main points are stated in the comments for transmission to the authors.Please note that all Primer articles follow the same set organization of the main headings. Additionally, Nature Reviews articles will be thoroughly edited before publication and all figures will be redrawn by our in-house art editors. We therefore request that you concentrate on the scientific content of the article and display items, rather than the 'order' of the content or any minor errors in language or grammar that might be present in the draft version. Please consider and comment on the following points when reviewing this manuscript:• Is the article written for a broad audience, including biomedical scientists, translational researchers, medical students and clinicians?• Is the global perspective well represented?• Does the article present the current state of the art in the disease, without much emphasis on historical aspects?• Are the open research questions outlines and comprehensive?• Does the length of the article seem appropriate?• Are the ideas logically presented and discussed?• Does the article provide a balanced overview of the literature? Please bear in mind that it may not be possible to cover all aspects of a field within such a concise article.• Is the discussion fair and accurate? Although our authors are encouraged to be opinionated, they should not ignore alternative points of view.• Do the figures, boxes and tables provide clear and accurate information? Are there any additional or alternative display items that you think that the authors should include?• Are the references appropriate and up-to-date? Do they reflect the scope of the article?• Are you aware of any undeclared conflicts of interest...

show abstract

mentioning

confidence: 99%

Psoriatic arthritis

FitzGerald

Ogdie

Chandran

et al. 2021

Nat Rev Dis Primers

163

View full text Add to dashboard Cite

show abstract

“…At the same time, there was an increase in the number of Dialister flora in ileal and colon biopsies of AS patients, which was positively correlated with AS disease activity score. 46 Intestinal T lymphocytes activated by intestinal pathogenic microbial antigens migrate to joints and induce inflammation. 47 In the inflammatory state, the release of various cytokines will cause vasodilation and increase vascular permeability, resulting in increased leukocyte infiltration.…”

Section: Intestinal Flora Regulation Mechanism Of Moxibustion In Anky...mentioning

confidence: 99%

Research Progress on Molecular Mechanism of Moxibustion in the Treatment of Ankylosing Spondylitis

Yan,

Huali,

et al. 2022

Chinese medicine and natural products

View full text Add to dashboard Cite

As an important part of traditional Chinese medicine (TCM) nursing technology, moxibustion plays a unique role in improving the symptoms of ankylosing spondylitis (AS). The research on the mechanism of moxibustion intervention in AS mainly focuses on anti-inflammatory effects, immune regulation, bone metabolism regulation, intestinal flora regulation, and so on. Molecular medicine is of great significance to further clarify the mechanism of moxibustion intervention in AS. However, there are still some problems in the research on the molecular mechanism of moxibustion intervention in AS: the existing biomedical research methods only explore from a specific field and lack the exploration of moxibustion-targeted molecules based on biomedical network. In the future, the molecular network effect of moxibustion on AS can be discussed comprehensively and systematically with the help of omics technology and the construction of biological information interaction network between omics. The effect of moxibustion on upstream osteogenic transcription factors and related signaling pathways such as WNT, β-catenin, and BMP/Smads is not yet clear. Future research can focus on the relevant signal targets of bone reconstruction and clarify the mechanism of moxibustion against the new bone formation. In addition, there is a lack of research on the molecular mechanism of moxibustion in the treatment of AS from the perspective of metabolites. It is necessary to further explore the mechanism of moxibustion in the treatment of AS with the help of metabonomics technology.

show abstract

“…Nonetheless, the increased severity and frequency of tarsitis in developed countries is probably associated with a higher incidence of intestinal infections. The relationship between gut inflammation and arthritis or enthesitis is a challenging research topic that includes intestinal dysbiosis and cell migration (120)(121)(122). It has been suggested that some inflammatory mediators like cytokines and leukocytes can be originated in the gut, and such could be the case of ILC3 cells (104) or Tγδ cells (123).…”

Section: Inflammatory Pathways In Axial and Peripheral Spamentioning

confidence: 99%

Inflammatory Foot Involvement in Spondyloarthritis: From Tarsitis to Ankylosing Tarsitis

et al. 2021

Self Cite

View full text Add to dashboard Cite

Spondyloarthritis (SpA) is a group that includes a wide spectrum of clinically similar diseases manifested by oligoarticular arthritis and axial or peripheral ankylosis. Although axial SpA is predominant in Caucasians and adult-onset patients, juvenile-onset and Latin American patients are characterized by severe peripheral arthritis and particularly foot involvement. The peripheral involvement of SpA can vary from tarsal arthritis to the most severe form named ankylosing tarsitis (AT). Although the cause and etiopathogenesis of axSpA are often studied, the specific characteristics of pSpA are unknown. Several animal models of SpA develop initial tarsitis and foot ankylosis as the main signs, emphasizing the role of foot inflammation in the overall SpA spectrum. In this review, we attempt to highlight the clinical characteristics of foot involvement in SpA and update the knowledge regarding its pathogenesis, focusing on animal models and the role of mechanical forces in inflammation.

show abstract

The Role of the Microbiome in Gut and Joint Inflammation in Psoriatic Arthritis and Spondyloarthritis

Cited by 37 publications

References 34 publications

Psoriatic arthritis

Psoriatic arthritis

Research Progress on Molecular Mechanism of Moxibustion in the Treatment of Ankylosing Spondylitis

Inflammatory Foot Involvement in Spondyloarthritis: From Tarsitis to Ankylosing Tarsitis

Contact Info

Product

Resources

About