The Role of the Microbiome in Gastrointestinal Cancer

Wroblewski, Lydia E.; Peek, Richard M.; Coburn, Lori A.

doi:10.1016/j.gtc.2016.04.010

Cited by 57 publications

(40 citation statements)

References 73 publications

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“…It is noteworthy, that many of these genes were also upregulated in our study (BST2, CXCL9, IFIT2, IFIT3, IFIT47, IGTP, IRF7, IRF9, IRGM, ISG15, MYH10, OASL2, RTP4 and USP18) and were uniquely expressed at the earlier stages of carcinogenesis (week 5) (36). Taken together, our results are consistent with recent findings indicating that cancer related changes in gut microbial composition may induce interferon associated responses that contribute to the early progression of colon cancer in animal models as well as humans (26,37–40). Additionally, many key genes associated with microbial immune response were upregulated at the RNA plus K4me3 levels, hence, they may act as key modifiers of cancer progression (26,38,41).…”

Section: Discussionsupporting

confidence: 93%

Assessment of histone tail modifications and transcriptional profiling during colon cancer progression reveals a global decrease in H3K4me3 activity

Triff

McLean

Konganti

et al. 2017

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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During colon cancer, epigenetic alterations contribute to the dysregulation of major cellular functions and signaling pathways. Modifications in chromatin signatures such as H3K4me3 and H3K9ac, which are associated with transcriptionally active genes, can lead to genomic instability and perturb the expression of gene sets associated with oncogenic processes. In order to further elucidate early pre-tumorigenic epigenetic molecular events driving CRC, we integrated diverse, genome-wide, epigenetic inputs (by high throughput sequencing of RNA, H3K4me3, and H3K9ac) and compared differentially expressed transcripts (DE) and enriched regions (DER) in an in-vivo rat colon cancer progression model. Carcinogen (AOM) effects were detected genome-wide at the RNA (116 DE genes), K9ac (49 DERs including 24 genes) and K4me3 (7678 DERs including 3792 genes) level. RNA-seq differential expression and pathway analysis indicated that interferon-associated innate immune responses were impacted by AOM exposure. Despite extensive associations between K4me3 DERs and colon tumorigenesis (1210 genes were linked to colorectal carcinoma) including FOXO3, GNAI2, H2AFX, MSH2, NR3C1, PDCD4 and VEGFA, these changes were not reflected at the RNA gene expression level during early cancer progression. Collectively, our results indicate that carcinogen-induced changes in gene K4me3 DERs are harbingers of future transcriptional events, which drive malignant transformation of the colon.

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Section: Discussionsupporting

confidence: 93%

Assessment of histone tail modifications and transcriptional profiling during colon cancer progression reveals a global decrease in H3K4me3 activity

Triff

McLean

Konganti

et al. 2017

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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“…This should be considered as cancers often require more than one factor to develop. Furthermore, bacterial profiles associated with gastro-intestinal lesions may be the result of the pathological change, rather than the underlying cause (Garrett, 2015; Wroblewski, Peek, & Coburn, 2016). Nonetheless, the association of Mycoplasma with exposed populations of zebrafish opens up additional avenues to study the transmission and etiology of this disease.…”

Section: Discussionmentioning

confidence: 99%

Transmission of a common intestinal neoplasm in zebrafish by cohabitation

Burns

Watral

Sichel

et al. 2017

Journal of Fish Diseases

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Intestinal neoplasms are common in zebrafish (Danio rerio) research facilities. These tumours are most often seen in older fish and are classified as small cell carcinomas or adenocarcinomas. Affected fish populations always contain subpopulations with preneoplastic lesions, characterized by epithelial hyperplasia or inflammation. Previous observations indicated that these tumours are unlikely caused by diet, water quality or genetic background, suggesting an infectious aetiology. We performed five transmission experiments by exposure of naïve fish to affected donor fish by cohabitation or exposure to tank effluent water. Intestinal lesions were observed in recipient fish in all exposure groups, including transmissions from previous recipient fish, and moribund fish exhibited a higher prevalence of neoplasms. We found a single 16S rRNA sequence, most similar to Mycoplasma penetrans, to be highly enriched in the donors and exposed recipients compared to unexposed control fish. We further tracked the presence of the Mycoplasma sp. using a targeted PCR test on individual dissected intestines or faeces or tank faeces. Original donor and exposed fish populations were positive for Mycoplasma, while corresponding unexposed control fish were negative. This study indicates an infectious aetiology for these transmissible tumours of zebrafish and suggests a possible candidate agent of a Mycoplasma species.

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“…There are many methods for the treatment of colon cancer. Researchers also through the study of human patients and rodent cancer models, found that the intestinal fl ora changes will increase the risk of cancer such as colon cancer [48][49][50][51][52].…”

Section: Therapymentioning

confidence: 99%

Mechanistic and Therapeutic Advances in Colon Cancer: A Systematic Review

Li¹,

Han²,

Zhang³

et al. 2019

Open J Proteom Genom

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Colon cancer is a common gastrointestinal malignancy in daily life and is the third most common cancer. So far, the global incidence of colon cancer has risen every year. Colon cancer mortality accounts for half of the incidence, colon cancer mortality ranks fi fth in malignant tumor mortality, which seriously threatens human survival and health. This article refers to the latest domestic and foreign related articles related to colon cancer. It summarizes common and emerging screening methods for colon cancer which can make early detection and early treatment of the disease for reducing the deterioration and metastasis of colon cancer. It discusses the diagnostic markers of colon cancer found out in recent years and its mechanism of action, to improve the level, accuracy and scientifi city of diagnosis. This article points out that the metastasis of colon cancer is the main cause of death in patients with colon cancer and to discuss the mechanism of its metastasis. It also summarizes the therapy thereof and advantages and disadvantages of colon cancer from different aspects such as intestinal fl ora, targeted therapy, traditional Chinese medicine and western medicine. Finally, the article summaries some methods that can effectively prevent colon cancer, reduce the occurrence of colon cancer from the source and improve people's quality of life.

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The Role of the Microbiome in Gastrointestinal Cancer

Cited by 57 publications

References 73 publications

Assessment of histone tail modifications and transcriptional profiling during colon cancer progression reveals a global decrease in H3K4me3 activity

Assessment of histone tail modifications and transcriptional profiling during colon cancer progression reveals a global decrease in H3K4me3 activity

Transmission of a common intestinal neoplasm in zebrafish by cohabitation

Mechanistic and Therapeutic Advances in Colon Cancer: A Systematic Review

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