The role of the main risk factors and endocrine cells of the antrum of the stomach producing motilin in the occurrence of cholelithiasis

Svistunov, Andrey; Осадчук, М А; Mironova, Ekaterina D.; Guliaev, Pavel V.; Vasilieva, I.N.

doi:10.26442/00403660.2022.02.201370

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…This is consistent with Andrey A et al's study emphasizing the connection between these metabolic diseases and gallbladder diseases. 20 In the sleep duration subgroup analysis, we found signi cant differences in the impact of trouble sleeping combined with different sleep durations on the risk of gallstones. The biological mechanisms underlying the relationship between trouble sleeping and gallstone formation are not fully elucidated but can be speculated as follows: 1.…”

Section: Discussionmentioning

confidence: 74%

Association of Trouble Sleeping with Increased Risk of Gallstone Disease in U.S. Adults: A Cross-Sectional Study of NHANES 2017-2020

Liu,

Huang,

Huang

et al. 2024

Preprint

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Background Trouble sleeping is prevalent in modern society and is known to be associated with various health problems. However, studies on the relationship between trouble sleeping and gallstones are relatively few. This study aims to explore the potential association between trouble sleeping and gallstones among adult Americans. Methods Data from the National Health and Nutrition Examination Survey (NHANES) 2017–2020 were analyzed, including 7,438 adult participants. The relationship between trouble sleeping and gallstones was assessed using multivariable logistic regression models, with sensitivity analyses performed using multiple imputation, weighted analysis, and propensity score matching. Results Among the 7,438 participants, 780 (10.5%) reported having gallstones. The analysis showed a significantly increased risk of gallstones among participants with trouble sleeping (adjusted odds ratio [AOR] = 1.49, 95% confidence interval [CI] = 1.26–1.76, P < 0.001). Subgroup analyses indicated consistent associations across different subgroups based on sex, age, obesity, diabetes, and hypertension, with interaction observed in age subgroups. Conclusion The findings suggest that trouble sleeping may be an independent risk factor for gallstones. This highlights the potential importance of improving sleep quality in the prevention of gallstones.

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Section: Discussionmentioning

confidence: 74%

Association of Trouble Sleeping with Increased Risk of Gallstone Disease in U.S. Adults: A Cross-Sectional Study of NHANES 2017-2020

Liu,

Huang,

Huang

et al. 2024

Preprint

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Motilin, vascular endothelial growth factor, and somatostatin expression in the gastric mucosa of patients with NSAID-gastropathy

Маев¹,

Осадчук²,

Krylova³

et al. 2022

Dok. gastroenterol.

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Expression of motilin and vasoactive intestinal peptide in diverticular disease of the colon

Osadchuk,

Mironova,

Krylova

et al. 2024

Terapevticheskii arkhiv

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Aim. To determine the role of the expression of motilin and vasoactive intestinal peptide (VIP) in diverticular disease of the large intestine (DD). Materials and methods. Examined 45 patients with DD. The comparison group consisted of 30 practically healthy people. Patients and healthy people were examined according to a single program, including clinical, instrumental (colonoscopy and ultrasound examination of the abdominal cavity and), laboratory (blood glucose, cholesterol, alanine aminotransferase and aspartate aminotransferase) and immunomorphological research methods – use of primary antibodies to motilin (PA5-76926, Invitrogen, USA) and VIP (Ab22736, 1:800, Abcam, UK). Results. For DD, clinical symptoms are characteristic, mainly fit into the manifestations of functional disorders (constipation, pain along the colon, bloating and increased gas formation). In patients with DD, an increase in body mass index, cholesterol and glucose levels was found. In this category of patients, examinations often verify diabetes mellitus (40%), arterial hypertension (64.4%), cholelithiasis (44.4%), non-alcoholic fatty liver disease (55.5%), gastroesophageal reflux disease (60%). In the group of patients with DD, a significant decrease in the expression of VIP and motilin in the mucous membrane of the large intestine was recorded compared with the group of healthy people (17.31 vs 34.67; p0.05 and 64.42 vs 76.50; p0.05 respectively). Conclusion. The obtained results give grounds to conclude that a decrease in the expression of VIP and motilin in the mucosa of the sigmoid colon is accompanied by hypotension of the colon, which directly and indirectly leads to a violation of the regeneration of the mucosa, which leads to the manifestation of DD.

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The role of the main risk factors and endocrine cells of the antrum of the stomach producing motilin in the occurrence of cholelithiasis

Cited by 4 publications

References 28 publications

Association of Trouble Sleeping with Increased Risk of Gallstone Disease in U.S. Adults: A Cross-Sectional Study of NHANES 2017-2020

Association of Trouble Sleeping with Increased Risk of Gallstone Disease in U.S. Adults: A Cross-Sectional Study of NHANES 2017-2020

Motilin, vascular endothelial growth factor, and somatostatin expression in the gastric mucosa of patients with NSAID-gastropathy

Expression of motilin and vasoactive intestinal peptide in diverticular disease of the colon

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