The Rôle of the Liver in Hematopoiesis

The Anemia of Liver Disease: Observations on Its Mechanism 1

“…The hypothesis that this anemia is metabolically similar to pernicious anemia and that it arises from defective storage of the subsequently identified Vitamin Bl2 (1)(2)(3) has been generally rejected for several reasons, namely: The morphologic dissimilarities of the two types of anemia (4,5); the failure of typical cases to respond to preparations containing Vitamin B,2 (6); the demonstration of anti-pernicious anemia activity in the liver of cirrhotic patients with macrocytic anemia (7); and the inability of liver extract to prevent anemia during experimental liver injury (8). More recently it has been suggested that another, unrelated metabolic defect exists (6), possibly exaggerated in some cases 1 This investigation was supported in part by research by hemodilution (9).…”

Nationality in the Soviet army

“…References to tensions between nationalities are few though the frequent contrary emphasis, identified by Goldhamer, on the way Soviet nationalities serve together "in a friendly fashion" may reflect an uneasy recognition of a problem. 6 Where unofficial samizdat publications are available, they are likely to be an equally unreliable source. Interviews with emigr~s who have served in the Soviet army have only been used as a major source since 1978.…”

“…25 This policy appears to reflect the perceived unreliability of non-Slavs. Politically unreliable Slavs are also sent to construction units) 6 The basic principle governing stationing is that of extra-territoriality. Soviet soldiers are generally not permitted to serve in their native regions though exceptions are often made by corrupt voenkomat officials.…”

The effect of experimental liver damage on the blood picture of the dog.

“…is an example, may result from: 1) the absence of a socalled intrinsic factor, normally contained in the gastric secretion (1,2); 2) the absence of an extrinsic factor associated with the nitrogenous portion of the d1et(3); 3) the lack of absorption (4,5,6,7,8) of the product of the interaction(2,9) of the intrinsic and extrinsic factors; 4) the interference with or derangement of the storage mechanism for this principle in the liver (10,11,12,13,14,15). Acute or chronic liver damage as seen clinically may be accompanied by a typical macrocytic hyperchromic anemia presenting in a greater or lesser degree the cytological changes characteristic of perniCiOUS anemia.…”