The Role of the Liver in Insulin Action and Resistance

Radziuk, J.; Pye, Susan

doi:10.1007/978-1-59259-716-1_11

Cited by 2 publications

(1 citation statement)

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“…In contrast, it is possible that the greater systemic insulin after splanchnicotomy was the conse-quence of the significantly larger glycemia in splanchnicotomized animals. Indeed, insulin liver extraction is highly variable, ranging from 20 to 80%, and is regulated acutely by portal glucose (38). In an isolated perfused rat liver, glucose perfusion (300 mg/dl) significantly reduced hepatic insulin extraction compared with no glucose perfusion (20).…”

Section: Discussionmentioning

confidence: 99%

The vagus is inhibitory of insulin secretion under fasting conditions

Blat

Malbert

2001

American Journal of Physiology-Endocrinology and Metabolism

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The involvement of the vagus in the insulin response during the early phase of absorption of a meal has been demonstrated recently. The extent of this vagal influence was investigated during fasting in an anesthetized porcine model. Portal and systemic insulin were evaluated together with glycemia during cooling and sectioning of both cervical vagal trunks in 12 splanchnicotomized or sham-operated pigs. In sham-operated animals, portal and systemic insulin were significantly and reversibly increased by cooling (173 and 123%, respectively). Portal insulin peaked 20 min after the onset of cooling but declined slowly while cooling was still activated. In contrast, systemic insulin was increased evenly along cooling. Section of the vagus was also associated with a portal and systemic insulin increase (144 and 117%) but to a lesser extent than cooling. In both treatments, portal and systemic insulin increases were either reduced (vagal cooling) or eliminated (vagal section) in splanchnicotomized animals. We conclude that the vagus exerts an inhibitory activity on interdigestive insulin secretion that is partly mediated by the splanchnic nerves.

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Section: Discussionmentioning

confidence: 99%