The role of the lecithin addition in the properties and cytotoxic activity of chitosan and chondroitin sulfate nanoparticles containing curcumin

Jardim, Katiúscia Vieira; Siqueira, Joseílma Luciana Neves; Báo, Sônia Nair; Parize, Alexandre Luís

doi:10.1016/j.carbpol.2019.115351

Cited by 45 publications

(23 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Noticeably, all prepared NPs (unloaded) exhibited significant cationic surface charges, as shown in Table 3 , even under variable pH conditions (except for CSP-LC-TPP, which became slightly negative at pH 7.4, Table 3 ), indicating that their outer shells were composed mainly of cationic CS or CSP, while negatively charged LC remained mainly within NP cores. This conclusion is in parallel with previous reports (Chu et al, 2019 ; Jardim et al, 2020 ; Murthy et al, 2020 ).…”

Section: Resultssupporting

confidence: 92%

Novel Ellipsoid Chitosan-Phthalate Lecithin Nanoparticles for siRNA Delivery

Saeed

Abdullah

Ahram

et al. 2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

Section: Resultssupporting

confidence: 92%

Novel Ellipsoid Chitosan-Phthalate Lecithin Nanoparticles for siRNA Delivery

Saeed

Abdullah

Ahram

et al. 2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…SD-NM showed a significantly higher release rate than SD-NLM1, which was approximately two times higher at 60 min, but both formulations released less than 10% in 1 h ( p < 0.05, ANOVA). This is thought to be because SD-NLM1 contains lecithin, which increases the hydrophobic properties of the microparticles and makes wetting difficult, thereby slowing the drug release [ 50 , 51 ]. It is known that esterases are the reason NFM is rapidly degraded when administered [ 13 , 35 , 36 ].…”

Section: Resultsmentioning

confidence: 99%

Co-Spray Dried Nafamostat Mesylate with Lecithin and Mannitol as Respirable Microparticles for Targeted Pulmonary Delivery: Pharmacokinetics and Lung Distribution in Rats

et al. 2021

View full text Add to dashboard Cite

Coronavirus disease 2019 (COVID-19), caused by a new strain of coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading rapidly worldwide. Nafamostat mesylate (NFM) suppresses transmembrane serine protease 2 and SARS-CoV-2 S protein-mediated fusion. In this study, pharmacokinetics and lung distribution of NFM, administered via intravenous and intratracheal routes, were determined using high performance liquid chromatography analysis of blood plasma, lung lumen using bronchoalveolar lavage fluid, and lung tissue. Intratracheal administration had higher drug delivery and longer residual time in the lung lumen and tissue, which are the main sites of action, than intravenous administration. We confirmed the effect of lecithin as a stabilizer through an ex vivo stability test. Lecithin acts as an inhibitor of carboxylesterase and delays NFM decomposition. We prepared inhalable microparticles with NFM, lecithin, and mannitol via the co-spray method. The formulation prepared using an NFM:lecithin:mannitol ratio of 1:1:100 had a small particle size and excellent aerodynamic performance. Spray dried microparticles containing NFM, lecithin, and mannitol (1:1:100) had the longest residual time in the lung tissue. In conclusion, NFM-inhalable microparticles were prepared and confirmed to be delivered into the respiratory tract, such as lung lumen and lung tissue, through in vitro and in vivo evaluations.

show abstract

“…Moreover, Dei Cas and Ghidoni [10] pointed out that, to increase the dietary intake of curcuminoids, turmeric should be paired with lecithin-rich products, such as vegetable oils or eggs. In a recent study, Jardim et al [11] demonstrated that the addition of lecithin is a promising strategy for improving the properties of nanoparticles such as curcumin, leading to its enhanced efficiency.…”

Section: Oral Bioavailability Of Curcuminmentioning

confidence: 99%

Curcumin and Its Potential Impact on Microbiota

et al. 2021

View full text Add to dashboard Cite

Curcumin is one of the most frequently researched herbal substances; however, it has been reported to have a poor bioavailability and fast metabolism, which has led to doubts about its effectiveness. Curcumin has antioxidant and anti-inflammatory effects, and has demonstrated favorable health effects. Nevertheless, well-reported in vivo pharmacological activities of curcumin are limited by its poor solubility, bioavailability, and pharmacokinetic profile. The bidirectional interactions between curcumin and gut microbiota play key roles in understanding the ambiguity between the bioavailability and biological activity of curcumin, including its wider health impact.

show abstract

The role of the lecithin addition in the properties and cytotoxic activity of chitosan and chondroitin sulfate nanoparticles containing curcumin

Cited by 45 publications

References 55 publications

Novel Ellipsoid Chitosan-Phthalate Lecithin Nanoparticles for siRNA Delivery

Novel Ellipsoid Chitosan-Phthalate Lecithin Nanoparticles for siRNA Delivery

Co-Spray Dried Nafamostat Mesylate with Lecithin and Mannitol as Respirable Microparticles for Targeted Pulmonary Delivery: Pharmacokinetics and Lung Distribution in Rats

Curcumin and Its Potential Impact on Microbiota

Contact Info

Product

Resources

About