The role of the KIBRA and APOE genes in developing spatial abilities in humans

Казанцева, А.; Enikeeva, R. F.; Davydova, Yu. D.; Мустафин, Р. Н.; Takhirova, Zalina; Malykh, Sergey; Lobaskova, Marina; Tikhomirova, Tatiana; Хуснутдинова, Э. К.

doi:10.18699/vj21.097

Cited by 8 publications

(10 citation statements)

References 32 publications

(47 reference statements)

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“…In addition, the studies unraveling the genetic basis of song perception and production in songbirds (zebra finch) succeeded to detect the impact of GRIN2B gene [1], which encodes a subunit of N-methyl-D-aspartate (NMDA) receptor (subtype of ionotropic glutamate-gated ion channel) involved in synaptic plasticity and learning. Although a recent study reported the role of GRIN2B rs3764030 located in the promoter gene region and GRIN2B A-allele, which is associated with elevated GRIN2B mRNA levels, in mental processing speed [28], the effect of GRIN2B gene variants on developing musical skills appeared to be non-significant in the present study, as well as in our previous study examining genetic role in spatial abilities [7].…”

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confidence: 92%

“…Twin research demonstrated that heritability estimates accounted for 0.21-0.68 depending on certain musical aptitudes [5]. Together with different types of personality abilities attributed to brain functioning such as mathematical abilities [6], spatial abilities [7], personality characteristics [8,9], musical aptitude represents a complex phenotype caused by the interaction of multiple genes and environmental factors [10].…”

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confidence: 99%

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A replication study of genetic variants associated with high-level musical aptitude

Казанцева¹,

Enikeeva²,

Toropova³

et al. 2023

RR. in B.

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Background: Existing genetic studies on musical abilities have focused on various molecular approaches, which determined gene regions/variants implicated in (i) music perception and performance based on genome-wide linkage and association scans, (ii) differential expression patterns as a response to music listening/performance, (iii) music production in songbirds, and (iiii) neuronal plasticity relation to music training. The aim of the study: The present study sought to examine the main and combined effects of related gene variants in developing musical abilities in individuals from Russia. In addition, we aimed to obtain the mathematical model with the optimal sensitivity to specificity ratio to predict individual liability for high-level musical aptitude. Materials and methods: A genotyping of the SNCA (rs356168, rs3910105), GATA2 (rs9854612), PCDH7 (rs13109270, rs13146789), UNC5C (rs9307160), ASAP1 (rs3057), SBSPON (rs1007750), GRIN2B (rs3764030), and BDNF (rs6265) gene variants was performed via real-time PCR with endpoint fluorescent detection in high-level musically skilled students (N = 100, 66% of women) in Moscow (Russia) and corresponding control group (N = 200, 67% of women). The main and combined effects of examined gene variants on developing musical abilities were assessed via logistic regression models followed by a selection of the best predicting model in R v.4.1.2. Results: We obtained a regression model (AUC = 0.735, P = 0.026), which can predict a higher probability to develop musical aptitude linked to SNCA rs356168 TT-genotype (β=1.98, P=0.011, OR=7.31, 95%CI 1.66-38.4), SNCA rs3910105 TC-genotype (β=1.39, P=0.034, OR=4.16, 95%CI 1.2-16.6), GATA2 rs9854612 A-allele (β=0.83, P=0.082, OR=2.30, 95%CI 0.91-6.11). Moreover, a significant effect of ASAP1 rs3057 on manifestation of musical skills was observed under the dominance deviation from additivity model (β=2.13, P=0.032, OR=1.94, 95%CI 1.05-3.56). Conclusion: Revealed findings testify in the involvement of dopaminergic neurotransmission and reward mechanisms attributed to α-synucleinand GATA2-mediated gene effects in ability to develop exaggerated musical skills.

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confidence: 92%

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confidence: 99%

A replication study of genetic variants associated with high-level musical aptitude

Казанцева¹,

Enikeeva²,

Toropova³

et al. 2023

RR. in B.

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“…At the same time, the immaturity of enzymatic systems determines a reduced efficacy of local immunity factors, antioxidant defense, and detoxification system of chemical substances [ 25 ]. Previously, our research group also demonstrated an unfavorable effect of rearing in urban residency on human cognitive abilities in the context of gene-by-environmental interactions, which was significant even in the present genetically “favorable” allele in the apolipoprotein E ( APoE ) gene [ 26 ]. A large number of published studies indicate a statistically significant influence of an unfavorable environment on shortening of telomeres, which, according to one of the studies [ 18 ], corresponds to a decrease in chronological age by 8.7–11.9 years in numerical equivalent (or 69–174 bp) with worsening environmental conditions.…”

Section: Discussionmentioning

confidence: 99%

Individual Differences in Relative Telomere Length in Mentally Healthy Subjects: The Effect of TERT Gene Polymorphism and Urban Residency

Казанцева

Davydova²,

Enikeeva³

et al. 2022

Russ J Genet

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The changes in the telomere length caused by the terminal underreplication in the existing literature are related to depressive disorders. However, the use of the telomere length as a biomarker of depressive states is ambiguous, which is due to the effect of various environmental factors on both the psychoemotional state and cellular aging of an organism. In order to identify the possible use of the relative telomere length (RTL) measured in peripheral blood leukocytes as a biomarker of enhanced liability to depression prior to the clinical symptoms, as well as to determine the link between telomere length, sociodemographic factors, allelic variants of the genes involved in the regulation of telomere elongation, and depression level, the association analysis of reverse transcriptase ( TERT rs7726159), telomerase RNA component ( TERC rs1317082), and the CST complex encoding protein ( OBFC1 rs2487999) gene polymorphisms was performed with RTL and depression level in mentally healthy individuals ( N = 1065) aged 18–25 years. Together with genetic variants, the examined regression models included various sociodemographic parameters as predictors. As a result of statistical analysis, we failed to observe the association between RTL and individual differences in depression level in the studied sample. Nevertheless, multiple regression analysis allowed us to construct a statistically significant model of individual variance in RTL ( P = 4.3е–4; r 2 = 0.018), which included rs7726159 in the TERT gene ( P = 0.020; β = 0.078) and such environmental predictors as age ( P = 0.001; β = –0.027) and place of residence in childhood (urban/rural area) ( P = 0.048; β = 0.063). The data obtained confirm the involvement of TERT gene variants and age in telomere length in mentally healthy individuals aged 18–25 years and indicate a negative effect of urban residency on telomere length shortening, which reflects the cellular aging of an organism.

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“…Cognitive functions represent a complex personality construct, the development of which is based on a large number of both biologically determined and environmental factors (Xu et al, 2015;Wang et al, 2019). In this regard, genetic data related to this cognitive phenotype are accumulating gradually, while the majority of studies are devoted to the examination of more obvious biological systems that can directly affect the transmission of information between the neurons, neurogenesis, differentiation of neurons, and others (Kazantseva et al, , 2021. The second reason may be attributed to the assumption that the brain as an organ is completely isolated from immune processes.…”

Section: Discussionmentioning

confidence: 99%

The role of inflammatory system genes in individual differences in nonverbal intelligence

et al. 2022

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Nonverbal intelligence represents one of the components of brain cognitive functions, which uses visual images and nonverbal approaches for solving required tasks. Interaction between the nervous and immune systems plays a specif ic role in individual differences in brain cognitive functions. Therefore, the genes encoding pro- and antiinf lammatory cytokines are prospective candidate genes in the study of nonverbal intelligence. Within the framework of the present study, we conducted the association analysis of six SNPs in the genes that encode proteins involved in inf lammatory response regulation in the central nervous system (CRP rs3093077, IL1А rs1800587, IL1B rs16944, TNF/ LTA rs1041981, rs1800629, and P2RX7 rs2230912), with nonverbal intelligence in mentally healthy young adults aged 18– 25 years without cognitive decline with inclusion of sex, ethnicity and the presence of the “risky” APOE ε4 allele as covariates. Considering an important role of environmental factors in the development of brain cognitive functions in general and nonverbal intelligence in particular, we conducted an analysis of gene-by-environment (G × E) interactions. As a result of a statistical analysis, rs1041981 and rs1800629 in the tumor necrosis factor gene (TNF) were shown to be associated with a phenotypic variance in nonverbal intelligence at the haplotype level (for АА-haplotype: βST = 1.19; p = 0.033; pperm = 0.047) in carriers of the “risky” APOE ε4 allele. Gene-by-environment interaction models, which determined interindividual differences in nonverbal intelligence, have been constructed: sibship size (number of children in a family) and smoking demonstrated a modulating effect on association of the TNF/LTA (rs1041981) (β = 2.08; βST = 0.16; p = 0.001) and P2RX7 (rs2230912) (β = –1.70; βST = –0.10; p = 0.022) gene polymorphisms with nonverbal intelligence. The data obtained indicate that the effect of TNF/LTA on the development of cognitive functions is evident only in the presence of the “unfavorable” APOE ε4 variant and/or certain environmental conditions.

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The role of the KIBRA and APOE genes in developing spatial abilities in humans

Cited by 8 publications

References 32 publications

A replication study of genetic variants associated with high-level musical aptitude

A replication study of genetic variants associated with high-level musical aptitude

Individual Differences in Relative Telomere Length in Mentally Healthy Subjects: The Effect of TERT Gene Polymorphism and Urban Residency

The role of inflammatory system genes in individual differences in nonverbal intelligence

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