The role of the insulin-like growth factor (IGF) axis in osteogenic and odontogenic differentiation

Abstract

The insulin-like growth factor (IGF) axis is a multicomponent molecular network which has important biological functions in the development and maintenance of differentiated tissue function(s). One of the most important functions of the IGF axis is the control of skeletal tissue metabolism by the finely tuned regulation of the process of osteogenesis. To achieve this, the IGF axis controls the activity of several cell types—osteoprogenitor cells, osteoblasts, osteocytes and osteoclasts to achieve the co-ordinated development of appropriate hard tissue structure and associated matrix deposition. In addition, there is an increasing awareness that the IGF axis also plays a role in the process of odontogenesis (tooth formation). In this review, we highlight some of the key findings in both of these areas. A further understanding of the role of the IGF axis in hard tissue biology may contribute to tissue regeneration strategies in cases of skeletal tissue trauma.

IGFBP7 regulates the osteogenic differentiation of bone marrow‐derived mesenchymal stem cellsviaWnt/β‐catenin signaling pathway

“…However, little is known about the effects and molecular mechanisms of IGFBP7 in stem cells (22). Therefore, we investigated its effects on the osteogenic differentiation of BMSCs.…”

IGF-1/IGF-1R/hsa-let-7c axis regulates the committed differentiation of stem cells from apical papilla

“…Various growth factors can mediate the osteo/dentinogenic differentiation of MSCs2345, including stem cells from apical papilla (SCAPs)6. These SCAPs can differentiate into odontoblasts or osteoblasts in vitro , and form dentin-like tissues along with tooth root-like structures in vivo 137.…”

“…One of the polypeptide growth factors (i.e., IGF-1) is the most important member of this axis7. Previous studies have revealed that IGF-1 can significantly enhance the odonto/osteogenic differentiation of SCAPs, periodontal ligament stem cells (PDLSCs) and dental pulp stem cells (DPSCs)689.…”

“…Previous studies have revealed that IGF-1 can significantly enhance the odonto/osteogenic differentiation of SCAPs, periodontal ligament stem cells (PDLSCs) and dental pulp stem cells (DPSCs)689. IGF-1 receptor (IGF-1R) is a cell membrane receptor that contains two transmembrane α subunits and two cytosolic β subunits covalently bonded through disulphide bridges7. It is commonly believed that IGF-1R can respond to IGF-1 to stimulate the osteoblast proliferation and bone matrix mineralization1011.…”

Bone Age and Serum Osteocalcin Levels in Children With Obstructive Sleep Apnea Hypopnea Syndrome Before and After Adenotonsillectomy

“…25 Secretion of insulin-like growth factor and associated proteins may promote GH secretion, which in turn promotes the conversion of osteoblasts. 26 In this study, we describe osteocalcin as a biomarker used to assess the treatment efficacy of GH deficiency, precocious puberty, abnormalities of glucocorticoid, and nutritional rickets, and is also a sensitive index for bone growth in OSAHS. 27,28 Previous studies have demonstrated that OSAHS alters the sleep state, increasing slow wave sleep (SWS), which results in depressing GH secretion, as GH secretion is known to peak in SWS.…”