The Role of the<i>IL-12</i>polymorphism rs3212227 in preeclampsia in Chinese Han Women

Wang, Xibing; Guo, Ming; Li, Sai; Gong, Jianfeng; Song, Weiqing; Wang, Haiyan; Liu, Shiguo

doi:10.3109/10641963.2015.1131289

“…The hypothesis that the IL‐12B rs3212227 SNP, a 3’‐untranslated region SNP associated with a variety of autoimmune diseases, for example, type 1 diabetes mellitus, may predispose to PE was tested in a 2011 case‐control study in 283 Brazilian women: No significant relationship was found ( P = 0.93) . To further support this finding, the effect of IL‐12B rs3212227 SNP in PE development in women of Chinese Han descent was estimated in a case‐control study of 1000 PE, further divided into mild and severe PE and early‐ and late‐onset PE, and 1287 normotensive controls: No difference was found between any of the PE groups and the control group nor was an association of the SNP with severity of PE established …”

Section: Resultsmentioning

confidence: 99%

The role of interleukins in preeclampsia: A comprehensive review

Bellos

¹

,

Karageorgiou

²

,

Kapnias

³

et al. 2018

American J Rep Immunol

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Preeclampsia is a multi‐system hypertensive disorder of pregnancy, with significant rates of maternal and neonatal morbidity. It represents a major cause of preterm birth, as definitive treatment demands fetal delivery. Although its pathophysiology is complicated, placental hypoxia and endothelial dysfunction constitute established pathogenetic steps of the disease. Inflammation is considered to be a crucial mediator of preeclampsia process, as an imbalance between TH1, TH2, and TH17 immune responses is observed. The present review accumulates current knowledge about the contribution of interleukins in preeclampsia, summarizing the pathways through which each interleukin exerts its function in the disease. Also, the role of genetic polymorphisms is explored and the predictive efficacy of maternal serum interleukin levels is evaluated. Finally, recommendations about the safe interpretation of the outcomes, as well as guidance for future research, are provided.

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“…However, other functional SNPs in the IL-17A gene has not been explored. Further, IL-12B (rs3212227) polymorphism was also not linked with PE predisposition in Han Chinese (Wang et al 2016). To best of our knowledge, association of IL-23A genetic variants with PE predisposition has not been studied.…”

Section: Introductionmentioning

confidence: 85%

IL-17A polymorphism (rs2275913) and levels are associated with preeclampsia pathogenesis in Chinese patients

Lang

¹

,

Liu

²

,

Hou

³

et al. 2020

Preprint

0

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Background Preeclampsia (PE) is a pregnancy-related condition that affects both the infant and the mother. Although the role of various inflammatory molecules in PE has been demonstrated, the importance of pro-inflammatory molecules such as IL-17A, IL-23 is not well understood. In the present investigation, a potential association of common genetic variants in the IL-17A and IL-23A genes with PE was investigated. Methods 115 PE clinically diagnosed patients who registered to the International Peace Maternity and Child Health Hospital were enrolled in this research. Age, sex-matched 102 pregnant women and 147 healthy Chinese women have also been included. ELISA was used to measure IL-17A and IL-23 serum levels in all enrolled subjects. Common genetic polymorphisms in IL-17A (rs 2275913, rs1974226, and rs1974226), IL-23A (rs11171806), and IL-12B (rs3212227) were genotyped using the PCR-RFLP or TaqMan probe-based method. Results Elevated serum IL-17A levels were found in PE patients compared to pregnant (P<0.0001) and healthy women (P<0.0001). However, IL-23 levels were comparable across various clinical groups. In addition, heterozygous (GA) and minor allele (A) for IL-17A (rs2275913) and IL-23A (rs11171806) were more prevalent in PE patients compared to pregnant women indicating an important role in the predisposition to PE growth. Interestingly, IL-17A (r 2275913) mutants were associated with elevated IL-17A levels relative to wild type (GG). Conclusions IL-17A (rs2275913) variants are associated with higher serum levels of cytokine, and predisposed PE development.

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“…However, other functional SNPs in the IL-17A gene has not been explored. Further, IL-12B (rs3212227) polymorphism was also not linked with PE predisposition in Han Chinese [3]. To best of our knowledge, association of IL-23A genetic variants with PE predisposition has not been studied.…”

Section: Introductionmentioning

confidence: 85%

IL-17A polymorphism (rs2275913) and levels are associated with preeclampsia pathogenesis in Chinese patients

Lang

¹

,

Liu

²

,

Hou

³

et al. 2020

Preprint

0

View full text Add to dashboard Cite

Background Preeclampsia (PE) is a pregnancy-related condition that affects both the infant and the mother. Although the role of various inflammatory molecules in PE has been demonstrated, the importance of pro-inflammatory molecules such as IL-17A, IL-23 is not well understood. In the present investigation, a potential association of common genetic variants in the IL-17A and IL-23A genes with PE was investigated. Methods 115 PE clinically diagnosed patients who registered to the International Peace Maternity and Child Health Hospital were enrolled in this research. Age, sex-matched 102 pregnant women and 147 healthy Chinese women have also been included. ELISA was used to measure IL-17A and IL-23 serum levels in all enrolled subjects. Common genetic polymorphisms in IL-17A (rs 2275913, rs1974226, and rs1974226), IL-23A (rs11171806), and IL-12B (rs3212227) were genotyped using the PCR-RFLP or TaqMan probe-based method. Results Elevated serum IL-17A levels were found in PE patients compared to pregnant (P<0.0001) and healthy women (P<0.0001). However, IL-23 levels were comparable across various clinical groups. In addition, heterozygous (GA) and minor allele (A) for IL-17A (rs2275913) and IL-23A (rs11171806) were more prevalent in PE patients compared to pregnant women indicating an important role in the predisposition to PE growth. Interestingly, IL-17A (r 2275913) mutants were associated with elevated IL-17A levels relative to wild type (GG). Conclusions IL-17A (rs2275913) variants are associated with higher serum levels of cytokine, and predisposed PE development.

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The Role of theIL-12polymorphism rs3212227 in preeclampsia in Chinese Han Women

Abstract: Our data suggested that IL-12B rs3212227 might not be a critical risk factor for PE in Chinese Han women.

Cited by 9 publications

References 30 publications

The role of interleukins in preeclampsia: A comprehensive review

The role of interleukins in preeclampsia: A comprehensive review

IL-17A polymorphism (rs2275913) and levels are associated with preeclampsia pathogenesis in Chinese patients

IL-17A polymorphism (rs2275913) and levels are associated with preeclampsia pathogenesis in Chinese patients

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