The role of the hypoxia signaling pathway in cellular adaptation to hypoxia

Titova, O.N.; Kuzubova, N.A.; Лебедева, Екатерина

doi:10.32364/2587-6821-2020-4-4-207-213

Cited by 7 publications

(1 citation statement)

References 35 publications

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“…Titova O.N., Kuzubova N.A., Lebedeva E.S. in their works, they proved that hypoxia, due to the action of HIF factor, can actively affect inflammatory processes by regulating oxygen-sensitive signaling pathways in multiple subtypes of immune cells [13]. All of the above adaptive mechanisms caused by hypoxia lead to an improvement in the clinical course of diseases and emergency rehabilitation.…”

Section: Introductionmentioning

confidence: 94%

Preservation of the immunomodulatory effect of interval hypoxytherapy after coronavirus infection in the long-term period

et al. 2023

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The new coronavirus infection COVID-19, due to the complex pathogenesis of the disease, systemic impact on organs, the development of complications and persistent disorders after the infection, remains an important medical problem. Every year the number of patients with postcovid syndrome in need of timely and full rehabilitation is increasing. Recently, isolated work began to appear on the use of interval hypoxytherapy for the treatment of patients with coronavirus infection. The purpose of our study was to identify the long-term results of the effect of interval hypoxytherapy on the immunological and coagulation status of patients after suffering coronavirus infection COVID-19. 170 patients aged 45 to 59 years were examined after a moderate coronavirus infection before, after and three months after interval hypoxytherapy. The number of lymphocytes, immunoglobulins A, M, G, E and cytokines (IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, TNFα) in blood, blood D-dimer, prothrombin time, fibrinogen in blood, antithrombin III, C-reactive was determined protein and ferritin in the blood. The conducted studies revealed changes in immunological reactivity after the coronavirus infection COVID-19, requiring correction. Interval hypoxytherapy had an immunomodulatory effect and led to the normalization of the main immunological parameters, which remained three months after hypoxytherapy: there was a significant (p < 0.05) increase in the number of CD3+T lymphocytes, CD4+T lymphocytes, CD8+T lymphocytes. The improvement in immune status was also evidenced by the normalization of the immunoregulatory index, an increase in the level of immunoglobulins A and G. The decrease in immunoglobulins E in the blood was an indicator of a decrease in the severity of sensitization of the body. The course of hypoxytherapy led to a decrease in the content of pro-inflammatory cytokines: IL-1β, IL-2, IL-6, IL-8, TNFα and an increase in anti-inflammatory cytokines: IL-4 and IL-10 in the blood, which indicated an attenuation of the inflammatory process in the lung tissue and in the body as a whole. Blood ferritin decreased 3 months after hypoxytherapy. As studies have shown, the effect of hypoxytherapy persists for three months after the course of treatment. Thus, interval hypoxytherapy can be recommended for the rehabilitation of patients after a moderate coronavirus infection. A repeated course of hypoxytherapy may be performed three months after the first course of hypoxytherapy.

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Section: Introductionmentioning

confidence: 94%

Preservation of the immunomodulatory effect of interval hypoxytherapy after coronavirus infection in the long-term period

et al. 2023

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Transport Functions of Serum Immunoglobulins among Residents of the European Arctic in the Russian Federation

Pashinskaya,

Samodova,

Dobrodeeva

2023

Biol Bull Russ Acad Sci

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Effect of interval hypoxic therapy in the hypoxia-hyperoxia mode on the hemostatic system of patients who have suffered a new coronavirus infection COVID-19

Misirova,

Tsuntaev,

Merzhoeva

et al. 2023

Kazan Med J

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Background. The positive effect of interval hypoxic therapy in the treatment of many diseases has become the basis for its use in rehabilitation after a new coronavirus infection to normalize disorders of the hemostatic system. Aim. To identify the peculiarities of the interval hypoxic therapy effect on the hemostatic system of patients who have suffered a new coronavirus infection. Material and methods. The work was carried out from April 2020 to May 2022. 220 men aged 4559 years (average age 48.82.4 years) were examined. The main group included 90 people who had a moderate coronavirus infection a month ago; the control group (n=70) was represented by relatively healthy people; the comparison group (n=60) suffered coronavirus infection and underwent standard rehabilitation without hypoxic therapy. The content of platelets, D-dimer, international normalized ratio, prothrombin time, activated partial thromboplastin time, antithrombin III activity, interleukin-6 level, and C-reactive protein content in the blood serum was determined. To assess statistically significant differences, a parametric method applying paired and unpaired Student's t-test was used. Differences were considered statistically significant at p 0.05. Results. In patients of the main group, a violation of the hemostatic system, indicating increased thrombogenicity of the blood against the background of persistent inflammatory activity, was revealed. After interval hypoxic therapy, the platelet count increased to 215.5323.57109/l (p=0.035), activated partial thromboplastin time to 26.741.84 s (p=0.035), international normalized ratio to 0.890.06 (p=0.005), antithrombin III activity in the blood up to 81.814.33% (p=0.007); the level of fibrinogen decreased to 3.861.09 g/l (p=0.035) and the content of D-dimer in the blood to 255.5817.36 ng/ml (p=0.035). There was a decrease in the level of interleukin-6 to 6.030.65 pg/ml (p=0.035) and C-reactive blood protein to 1.030.15 mg/l (p=0.035). Conclusion. Interval hypoxic therapy had a normalizing effect on the hemostatic system of patients who suffered a new coronavirus infection, as a result of suppressing the inflammatory process in the body.

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The role of the hypoxia signaling pathway in cellular adaptation to hypoxia

Cited by 7 publications

References 35 publications

Preservation of the immunomodulatory effect of interval hypoxytherapy after coronavirus infection in the long-term period

Preservation of the immunomodulatory effect of interval hypoxytherapy after coronavirus infection in the long-term period

Transport Functions of Serum Immunoglobulins among Residents of the European Arctic in the Russian Federation

Effect of interval hypoxic therapy in the hypoxia-hyperoxia mode on the hemostatic system of patients who have suffered a new coronavirus infection COVID-19

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