Abstract:Dear Sir, I read with great interest the paper by Keränen and Kuusisto (2016) reporting a rapid and substantial decrease in the plasma concentration of valproic acid (VPA) within 24 hours after beginning concomitant treatment with imipenem. When imipenem treatment was stopped four days later, the VPA plasma concentration increased within a few hours. The authors conclude that this time course suggests that mechanisms other than a change in the enzymatic elimination of VPA are the cause for the pharmacokinetic … Show more
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