The role of the hematological inflammatory index and systemic immuno-inflammation index in acute cholecystitis

Abstract

Introduction and aim. Acute cholecystitis is one of the most common hepatobiliary emergencies. We aimed to investigate the role of the initial hematological inflammatory index and systemic immuno-inflammation index in predicting short-term mortality in patients with acute cholecystitis. Material and methods. This study with a retrospective observational design was conducted at the emergency department of a tertiary teaching hospital. Patients admitted to our clinic between June 15, 2021, and March 15, 2022, according to the Tokyo criteria were included in the sample. The hematological inflammatory index and systemic immuno-inflammation index were calculated using the hematological test results of the patients evaluated at the emergency department. Survivor and non-survivor groups were formed according to all-cause 30-day mortality. The differences between survivor and non-survivor groups were investigated. Results. A total of 194 patients were included in the final analysis. The median age of the study population was 59 (25th–75th percentiles: 46.75–72) years. The rate of all cause-short-term mortality was 7.7. There were significant differences between the survivor and non-survivor groups in terms of the neutrophil count and the systemic immuno-inflammation index (p=0.007, 0.034, respectively; Mann-Whitney U test). No significant difference was found in the remaining laboratory parameters (lymphocyte count, platelet count, and hematological inflammatory index) (p=0.220, 0.489, 0.367 respectively; Mann-Whitney U test). Conclusion. The systemic immuno-inflammation index was determined to be significantly higher in the non-survivor group than in the survivor group among the patients with acute cholecystitis. However, there was no significant difference between these two groups in relation to the hematological inflammatory index.

The Role of Different Systemic Inflammatory Indexes Derived from Complete Blood Count in Differentiating Acute from Chronic Calculus Cholecystitis and Predicting Its Severity

“… 33 It has also demonstrated associations with short-term outcomes and advanced forms of acute cholecystitis. 13 , 34 Within our study, we observed that the cutoff value of SII for differentiating between ACC and CCC was 896.8, and for predicting MS-ACC it was >1261. These findings indicated the potential clinical utility value of SII in assessing the severity and prognosis of acute cholecystitis.…”

Investigation of the prognostic role of systemic immunoinflammatory index in patients with acute pancreatitis

“…For example, SII was noted to be significantly higher in the non-survivor patients with acute cholecystitis than in the survivors in a Turkish study. [15] A high level of SII is an independent risk factor for short survival of patients with metastatic and unresectable pancreatic cancer. Patients with a high level of the inflammatory markers SII, neutrophil-to-lymphocyte count neutrophil/lymphocyte ratio (NLR), and the platelet-to-lymphocyte count, may be more prone to early liver metastasis.…”

Sistemik immün inflamasyon indeksi, akut apandisitli hastalarında komlikasyonun doğru erken tahmini için yeni ve güçlü bir belirteç olabilir

“…Despite the discrepancies concerning the cut-off values, we believe that NLR is an important parameter in the diagnosis of AA and in differentiating between complicated and uncomplicated cases. SII, a new-generation comprehensive systemic inflammatory index, has been reported to be a prognostic marker in some malignant diseases, autoimmune diseases, such as Behçet's disease and ankylosing spondylitis, abdominal infections, and many other diseases and conditions, from low-level infection to sepsis 19,20,[26][27][28][29] . It has been suggested that SII is a more successful marker than PLR and NLR in showing inflammation and immune response [20][21][22][23][24][25][26][27] .…”

“…The literature has reported that parameters such as red blood cell distribution width, the neutrophil/lymphocyte ratio (NLR), and the platelet/lymphocyte ratio (PLR) are important indicators of systemic inflammation and can be used to determine its prognosis 8,[15][16][17] . The systemic immune-inflammatory index (SII) is a new inflammatory index developed to simultaneously reveal the inflammatory and immune status of patients through the calculation of neutrophil count × platelet count / lymphocyte count 18,19 . SII has been shown to be an accurate marker for inflammation and immune response 20 .…”