The role of the gut microbiome in cancer-related fatigue: pilot study on epigenetic mechanisms

Xiao, Canhua; Fedirko, Veronika; Beitler, Jonathan J.; Bai, Jinbing; Peng, Gang; Zhou, Chao; Gu, Jianlei; Zhao, Hongyu; Lin, I‐Hsin; Chico, Cynthia E; Jeon, Sangchoon; Knobf, Tish; Conneely, Karen N.; Higgins, Kristin; Shin, Dong M.; Saba, Nabil F.; Miller, Andrew H.; Bruner, Deborah Watkins

doi:10.1007/s00520-020-05820-3

Cited by 37 publications

(43 citation statements)

References 46 publications

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“…A case report published by the same author compared ME/CFS-discordant monozygotic twins and also identified abundance of Bifidobacterium and Faecalibacterium to be reduced in the affected twin compared to the non-affected one in addition to lower gut alpha diversity ( 164 ). Interestingly, a reduction of Faecalibacterium was also found in IBD patients with fatigue (compared to IBD patients without fatigue) ( 165 ), cancer-related fatigue (compared to cancer patients with low fatigue) ( 166 ) and other autoimmune diseases such as MS ( 167 , 168 ) and diabetes type 1 ( 169 ).…”

Section: The Role Of the Gut Microbiome In Me/cfsmentioning

confidence: 99%

The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)

et al. 2022

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Myalgic encephalomyelitis (ME) or Chronic Fatigue Syndrome (CFS) is a neglected, debilitating multi-systemic disease without diagnostic marker or therapy. Despite evidence for neurological, immunological, infectious, muscular and endocrine pathophysiological abnormalities, the etiology and a clear pathophysiology remains unclear. The gut microbiome gained much attention in the last decade with manifold implications in health and disease. Here we review the current state of knowledge on the interplay between ME/CFS and the microbiome, to identify potential diagnostic or interventional approaches, and propose areas where further research is needed. We iteratively selected and elaborated on key theories about a correlation between microbiome state and ME/CFS pathology, developing further hypotheses. Based on the literature we hypothesize that antibiotic use throughout life favours an intestinal microbiota composition which might be a risk factor for ME/CFS. Main proposed pathomechanisms include gut dysbiosis, altered gut-brain axis activity, increased gut permeability with concomitant bacterial translocation and reduced levels of short-chain-fatty acids, D-lactic acidosis, an abnormal tryptophan metabolism and low activity of the kynurenine pathway. We review options for microbiome manipulation in ME/CFS patients including probiotic and dietary interventions as well as fecal microbiota transplantations. Beyond increasing gut permeability and bacterial translocation, specific dysbiosis may modify fermentation products, affecting peripheral mitochondria. Considering the gut-brain axis we strongly suspect that the microbiome may contribute to neurocognitive impairments of ME/CFS patients. Further larger studies are needed, above all to clarify whether D-lactic acidosis and early-life antibiotic use may be part of ME/CFS etiology and what role changes in the tryptophan metabolism might play. An association between the gut microbiome and the disease ME/CFS is plausible. As causality remains unclear, we recommend longitudinal studies. Activity levels, bedridden hours and disease progression should be compared to antibiotic exposure, drug intakes and alterations in the composition of the microbiota. The therapeutic potential of fecal microbiota transfer and of targeted dietary interventions should be systematically evaluated.

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Section: The Role Of the Gut Microbiome In Me/cfsmentioning

confidence: 99%

The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)

et al. 2022

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“…Peptostreptococcaceae , a decarboxylating amino acid family [ 51 ], has been found in the human liver [ 60 ] and was associated with a high-caloric diet in mice [ 61 ]. Family XIII is known to increase in a high-fat diet [ 62 ] and is associated with inflammation [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Fecal Microbiota Transplant from Human to Mice Gives Insights into the Role of the Gut Microbiota in Non-Alcoholic Fatty Liver Disease (NAFLD)

et al. 2021

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Non-alcoholic fatty liver diseases (NAFLD) are associated with changes in the composition and metabolic activities of the gut microbiota. However, the causal role played by the gut microbiota in individual susceptibility to NAFLD and particularly at its early stage is still unclear. In this context, we transplanted the microbiota from a patient with fatty liver (NAFL) and from a healthy individual to two groups of mice. We first showed that the microbiota composition in recipient mice resembled the microbiota composition of their respective human donor. Following administration of a high-fructose, high-fat diet, mice that received the human NAFL microbiota (NAFLR) gained more weight and had a higher liver triglycerides level and higher plasma LDL cholesterol than mice that received the human healthy microbiota (HR). Metabolomic analyses revealed that it was associated with lower and higher plasma levels of glycine and 3-Indolepropionic acid in NAFLR mice, respectively. Moreover, several bacterial genera and OTUs were identified as differently represented in the NAFLR and HR microbiota and therefore potentially responsible for the different phenotypes observed. Altogether, our results confirm that the gut bacteria play a role in obesity and steatosis development and that targeting the gut microbiota may be a preventive or therapeutic strategy in NAFLD management.

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“…Meditation training has been widely used for the treatment of a variety of psychological, cardiovascular, and digestive diseases as well as chronic pain. On the contrary, it was reported under-represent among Clostridium di cile infection (CDI) [42], high cancer-related fatigue [43] and food allergy [44]. In this study, we found that the abundance in Subdoligranulum was positively correlated with the trait-anxiety score in high-responder group.…”

Section: Discussionmentioning

confidence: 55%

Gut Microbiota Associated with Effectiveness and Responsiveness to Mindfulness-Based Cognitive Therapy in Improving Trait Anxiety

wang

Liu

et al. 2021

Preprint

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ObjectiveThe mindfulness based interventions have been widely demonstrated effective on reducing stress, alleviating mood disorders and improving quality of life; however, the underlying mechanisms remained to be fully understood. Along with the advanced research in microbiota-gut-brain axis, this study aimed to explore the impact of gut microbiota on the effectiveness and responsiveness to mindfulness-based cognitive therapy (MBCT) among high trait anxiety populations.DesignA standard mindfulness-based cognitive therapy (MBCT) was performed among 21 young adults with high trait anxiety. A total of 29 healthy controls were matched for age and sex. The differences on gut microbiota between the two groups were compared. The changes of fecal microbiota and psychological indicators were also investigated before and after the intervention. ResultsCompared with healthy controls, we found markedly decreased bacterial diversity and distinctive clusters among high trait-anxiety populations, with significant overgrowth of bacteria such as Streptococcus, Blautia, Romboutsia, and decrease of genera such as Faecalibacterium, Coprococcus_3, Lachnoclostridium. Moreover, MBCT attenuated trait-anxiety and depression, improved mindfulness and resilience, and turned gut microbiota more close to that of healthy controls. Notably, high burden of intestinal Subdoligranulum pre-MBCT was associated with an increased responsiveness to MBCT. Decreases in Subdoligranulum post-MBCT were indicative of ameliorated trait anxiety. The tryptophan metabolism pathways were significantly over-represented among high-responders compared to low-responders.Conclusion The significantly increased diversity post-MBCT added evidence to gut-brain communication, and highlighted the utility of mycobiota-focused strategies for promoting effectiveness and responsiveness of the MBCT to improve trait anxiety.Trial registration: Chictr.org.cn, ChiCTR1900028389. Registered 20 December 2019, http://www.chictr.org.cn/edit.aspx?pid=47167&htm=4

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The role of the gut microbiome in cancer-related fatigue: pilot study on epigenetic mechanisms

Cited by 37 publications

References 46 publications

The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)

The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)

Fecal Microbiota Transplant from Human to Mice Gives Insights into the Role of the Gut Microbiota in Non-Alcoholic Fatty Liver Disease (NAFLD)

Gut Microbiota Associated with Effectiveness and Responsiveness to Mindfulness-Based Cognitive Therapy in Improving Trait Anxiety

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