The role of the gut microbiome in host systems

Febinia, Clarissa A.; Ha, Connie; Le, Chau; Holmes, Andrew

doi:10.1071/ma15005

Cited by 1 publication

(2 citation statements)

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“…The resistance potential aside, the intended accumulation of bioavailable silver in the gut with Ag ingestion could eradicate beneficial resident microflora, leading to colonization and overgrowth of pathogens in the gut . It has also been well-established that changes in the dynamic and balance of gut microflora may lead to an array of undesirable host functions, including inflammation and disrupted energy balance. , …”

Section: The Terminology Of Bioavailable Silver From Nanosilvermentioning

confidence: 99%

“…75 It has also been well-established that changes in the dynamic and balance of gut microflora may lead to an array of undesirable host functions, including inflammation and disrupted energy balance. 1,76 Development of resistance to bioavailable silver by microorganisms residing in an individual increases the vulnerability of that individual to infections arising, for example, from medical procedures that rely on silver as an antimicrobial in situations where antibiotics are less effective (e.g., catheter insertion). The resistant microorganisms may spread to other individuals and the environment, thereby increasing the pool of resistance determinants.…”

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confidence: 99%

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Widespread and Indiscriminate Nanosilver Use: Genuine Potential for Microbial Resistance

Gunawan

Marquis²,

Amal³

et al. 2017

ACS Nano

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In this era of increasing antibiotic resistance, the use of alternative antimicrobials such as silver has become more widespread. Superior antimicrobial activity has been provided through fabrication of silver nanoparticles or nanosilver (NAg), which imparts cytotoxic actions distinct from those of bulk silver. In the wake of the recent discoveries of bacterial resistance to NAg and its rising incorporation in medical and consumer goods such as wound dressings and dietary supplements, we argue that there is an urgent need to monitor the prevalence and spread of NAg microbial resistance. In this Perspective, we describe how the use of NAg in commercially available products facilitates prolonged microorganism exposure to bioavailable silver, which underpins the development of resistance. Furthermore, we advocate for a judicial approach toward NAg use in order to preserve its efficacy and to avoid environmental disruption.

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Section: The Terminology Of Bioavailable Silver From Nanosilvermentioning

confidence: 99%

mentioning

confidence: 99%