The role of the gut and microbes in the pathogenesis of spondyloarthritis

Abstract

The intestinal microbiota is firmly implicated not only in the pathogenesis of inflammatory bowel disease (IBD) but increasingly also in the development of inflammation at extraintestinal tissue sites. Significant clinical, genetic, immunological, and microbio-logical overlap exists between IBD and spondyloarthritis (SpA), which indicates that pathophysiological mechanisms are shared between these diseases and may center on the intestinal micro-biota. Recently, culture-independent techniques have enabled the microbiota in health and disease to be described in increasing detail. Moreover, functional studies have identified myriad host effector and regulatory pathways that shape or are shaped by this microbial community. We consider the complex relationship between SpA pathogenesis and gut microbes, with a discussion of how manipulation of the gut microbiota itself may be a promising future target for SpA therapy.

Rheumatoid arthritis–celiac disease relationship: Joints get that gut feeling

“…There was a significant improvement in the nutri-313 tionally restricted patients, accompanied by reduced antibodies levels 314 to food antigens, atheroprotection and anti-inflammatory effects [95, 315 96]. These observations together with the high incidence of subclinical 316 gut inflammation, shown 20 years ago, in chronic arthritis conditions 317 [97], the increased mucosal permeability in inflammatory rheumatic 318 diseases [98] and the recently described intestinal dysbiotic importance 319 in arthritis pathogenesis[99], support arguments for gut-joint inter-320 play, setting-up the stage for the following paragraph on the corre-321 sponding pathophysiology.…”

Troubles fonctionnels intestinaux et rhumatismes

“…Des mécanismes physiopathologiques communs comme par exemple une altération du microbiote [27,28] ou une inflammation intestinale infraclinique [29] pourraient favoriser la coexistence de ces pathologies. On ne dispose cependant pour l'instant d'aucune étude en faveur d'une augmentation de la fré-quence de l'association de ces pathologies rhumatismales au SII.…”

Patients with ankylosing spondylitis have been breast fed less often than healthy controls: a case–control retrospective study

“…Recently, it has been shown that the occurrence of spondyloarthritis is influenced by the intestinal microbiota 6 7. Microbiota acquisition begins at birth and continues throughout the first months of life.…”