“…There was a significant improvement in the nutri-313 tionally restricted patients, accompanied by reduced antibodies levels 314 to food antigens, atheroprotection and anti-inflammatory effects [95, 315 96]. These observations together with the high incidence of subclinical 316 gut inflammation, shown 20 years ago, in chronic arthritis conditions 317 [97], the increased mucosal permeability in inflammatory rheumatic 318 diseases [98] and the recently described intestinal dysbiotic importance 319 in arthritis pathogenesis[99], support arguments for gut-joint inter-320 play, setting-up the stage for the following paragraph on the corre-321 sponding pathophysiology.…”