The Role of the Gluten-Free Diet in the Management of Seronegative Enteropathy

Szaflarska-Popławska, Anna

doi:10.3390/nu13114027

Cited by 1 publication

(1 citation statement)

References 57 publications

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“…Secondly, resolution of symptoms and enteropathy after gluten withdrawal is an essential criterion to confirm the diagnosis of seronegative celiac disease (SNCD) in patients carrying permissive genes (HLA DQ2.5, DQ8, DQ2.2. and DQ7.5), which is a recently acknowledged entity, especially in the adult population [ 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ]. At this point, inadequate adherence to the GFD is a severe handicap for testing and verifying the diagnosis of SNCD [ 1 , 2 , 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

The Gluten-Free Diet for Celiac Disease: Critical Insights to Better Understand Clinical Outcomes

Simón,

Molero-Luis,

Fueyo-Díaz

et al. 2023

Nutrients

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The gluten-free diet (GFD) remains a complex paradigm in managing celiac disease (CeD) in children and adults, and there are many reasons why GFD adherence should be strict to improve outcomes. However, this is a challenging task for patients, since they need to have access to quality healthcare resources that facilitate optimal GFD adherence. Understanding the strengths and weaknesses of the GFD, tackling coexisting nutritional deficiencies, and dealing with complex situations, such as seronegative CeD or non-responsive CeD, all require the involvement of a multidisciplinary team. The short- and long-term follow-up of CeD patients should preferably be performed by a combined Gastroenterology and Nutrition service with well-defined quality standards and the multidisciplinary involvement of physicians, nurses, dietitians, and psychologists. Nutritional advice and counseling by an experienced dietitian can reduce the costs associated with long-term follow-up of CeD patients. Likewise, psychological interventions may be essential in specific scenarios where implementing and sustaining a lifelong GFD can cause a significant psychological burden for patients. This manuscript aims to provide guidelines to improve clinical practice in the follow-up and monitoring of CeD patients and provide information on the nutritional risks of an ill-advised GFD. Clinicians, biochemists, food technologists, dietitians, and psychologists with a global view of the disease have been involved in its writing.

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